Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction

2016 ◽  
Vol 9 ◽  
pp. 62-67 ◽  
Author(s):  
I. Kister ◽  
E. Johnson ◽  
E. Raz ◽  
J. Babb ◽  
J. Loh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Spinal Cord Infarction ◽  
Mri Findings ◽  
Acute Transverse Myelitis

Acute Transverse Myelitis Associated with COVID-19 vaccine: A Case Report

2021 ◽  
Vol 12 (3) ◽  
pp. 2083-2087
Author(s):  
Ali Alshararni
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Acute Inflammation ◽  
Transverse Myelitis ◽  
Preventive Measure ◽  
Mri Findings ◽  
Dorsal Spinal Cord ◽  
Lumbosacral Spinal Cord ◽  
Acute Transverse Myelitis ◽  
Magnetic Resonance Imaging Mri

The case report demonstrates the issue of Khalid Ali, who is a citizen of Yamen, explicitly living in Saudi Arabia. He is 38 years, weighs 82kgs, and of 162 cm in height. He is a sales professional and married with two kids. Khalid Ali has been living healthy until two years ago when he started experiencing pains in his lower extremities accompanied by numbness. He was treated, and everything went back to normal until soon when the case came back after the administration of the Pfizer vaccine as a preventive measure for COVID-19 disease. The consequence of the administration of the Pfizer vaccine resulted in severe pain and weaknesses in his legs and severe headache on the second day, which resulted in him being put on an ICU after 48 hours since he was almost paralyzed. A series of tests were conducted on him, including magnetic resonance imaging (MRI), hematology, and biochemistry which involved Cerebrospinal Fluid (CSF) protein test. MRI findings were significant since they indicated acute inflammation on the spine observed on the dorsal spinal cord with contrast and lumbosacral spinal cord. All the hematology tests turned out to be expected. Biochemistry conducted tests were similarly standard except for CSF protein which was highly abnormal. The combination of the high abnormal CSF protein test and acute inflammation of the spine observed from the MRI findings were confirmed evidence of acute transverse myelitis as a result of the administration of the Pfizer vaccine.

Short segment myelitis as a first manifestation of neuromyelitis optica spectrum disorders

2017 ◽  
Vol 23 (3) ◽  
pp. 413-419 ◽  
Author(s):  
So-Young Huh ◽  
Su-Hyun Kim ◽  
Jae-Won Hyun ◽  
In Hye Jeong ◽  
Min Su Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuromyelitis Optica ◽  
Transverse Myelitis ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Mri Findings ◽  
Initial Manifestation ◽  
Short Transverse ◽  
Imaging Characteristics ◽  
Referral Hospitals ◽  
Spectrum Disorders

Background: Some patients with neuromyelitis optica spectrum disorders (NMOSD) present with spinal cord lesions extending fewer than three vertebral segments (short transverse myelitis, STM), hindering an early diagnosis. Objective: We investigated the frequency and imaging characteristics of STM lesions in patients presenting with myelitis as an initial manifestation of NMOSD. Methods: Patients seen at three referral hospitals in Korea between June 2005 and March 2015 who met the following inclusion criteria were recruited for review: seropositivity for aquaporin-4 antibody, initial presentation with myelitis and spinal cord magnetic resonance imaging (MRI) performed within 1 month of initial myelitis onset. Results: Of the 76 enrolled patients, 65 (85.5%) collectively had 69 longitudinally extensive transverse myelitis lesions, while the remaining 11 (14.5%) had a total of 15 STM lesions. Of the 15 STM lesions, 5 spanned 2.5 vertebral segments, 6 were continuous over two segments, 3 showed a length of 1.5 segments and 1 was confined to a single segment. On axial imaging, all of the STM lesions involved the central grey matter. Conclusion: These MRI findings suggested that STM does not preclude the possibility of an NMOSD diagnosis.

Spinal cord infarction: Not to be mistaken for acute transverse myelitis

2017 ◽  
Vol 21 ◽  
pp. e173
Author(s):  
Eusra Hassan ◽  
Dipak Ram ◽  
Siobhan West ◽  
Gary McCullagh
Keyword(s):  
Spinal Cord ◽  
Transverse Myelitis ◽  
Spinal Cord Infarction ◽  
Acute Transverse Myelitis

A Case of Acute Transverse Myelitis Affecting the Entire Length of the Spinal Cord

1997 ◽  
Vol 37 (4) ◽  
pp. 247-248 ◽  
Author(s):  
Tomihiro Imai ◽  
Hiroyuki Matsumoto ◽  
Yukiko Ohkubo ◽  
Hirohiko Shizukawa ◽  
Susumu Chiba ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transverse Myelitis ◽  
Entire Length ◽  
Acute Transverse Myelitis

Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies

2021 ◽  
Vol 14 (1) ◽  
pp. e238992
Author(s):  
Katherine Thornley ◽  
Carlo Canepa
Keyword(s):  
Spinal Cord ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Sensory Level ◽  
Mri Scan ◽  
Acute Transverse Myelitis ◽  
Longitudinal Extensive Transverse Myelitis ◽  
Oral Steroids ◽  
Extensive Transverse Myelitis

An 80-year-old, previously healthy patient presents with acute transverse myelitis with sensory level at T8. The MRI scan of the spinal cord showed longitudinal extensive transverse myelitis, and she tested positive for aquaporin 4 antibodies in serum. She received treatment with intravenous and oral steroids, with no improvement and then underwent plasma exchange. She was then started on azathioprine for prevention of relapses, while continuing physiotherapy and occupational therapy. Eventually, she was transferred to a specialised spinal cord centre for long-term rehabilitation.

scholarly journals Vaccine Induced Acute Transverse Myelitis: A Case Report

2016 ◽  
Vol 13 (2) ◽  
pp. 89-91 ◽  
Author(s):  
Avinash Chandra ◽  
Reema Rajbhandari ◽  
Samir Acharya ◽  
Priya Gurung ◽  
Basant Pant
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Adverse Reactions ◽  
Transverse Myelitis ◽  
Active Immunization ◽  
Acute Transverse Myelitis ◽  
Autoimmune Phenomenon ◽  
Improve Accuracy ◽  
Post Traumatic ◽  
Post Infectious

Acute transverse myelitis is a focal infl ammatory disorder of the spinal cord. One of the main etiologic factors include, multiple sclerosis, post-infectious and post-traumatic events although autoimmune phenomenon is the most common cause. Transverse Myelitis (TM) due to etiology other than Multiple Sclerosis has shown spinal cord involvement of two or more segments. Annually millions of active immunization with vaccines is carried out globally with few transverse myelitis caused because of the adverse reactions due to these vaccinations. In order to improve accuracy of reporting, research and diagnosis, the Transverse Myelitis Consortium Working Group (TMCWG) have produced criteria for the diagnosis of ATM. Here we report a case of TM in adult, diagnosed as TM consistent with the TMCWG criteria and probably this is the first ever been reported case from Nepal. Nepal Journal of Neuroscience. Vol. 13, No. 2, 2016, Page: 89-91 

Neuromyelitis Optica

2017 ◽  
Author(s):  
Teri L. Schreiner ◽  
Jeffrey L. Bennett
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Water Channel ◽  
Transverse Myelitis ◽  
Inflammatory Disorder ◽  
The Central Nervous System

Neuromyelitis optica (NMO), or Devic’s disease is an inflammatory disorder of the central nervous system that preferentially affects the optic nerves and spinal cord. Initially considered a variant of multiple sclerosis (MS), NMO is now clearly recognized to have distinct clinical, radiographic, and pathologic characteristics. Historically, the diagnosis of NMO required bilateral optic neuritis and transverse myelitis; however, the identification of a specific biomarker, NMO-IgG, an autoantibody against the aquaporin-4 (AQP4) water channel, has broadened NMO spectrum disease to include patients with diverse clinical and radiographic presentations. This chapter addresses the diagnosis, pathophysiology, and management of the disease.

An autopsied case of neuromyelitis optica with a large cavitary cerebral lesion

2005 ◽  
Vol 11 (6) ◽  
pp. 735-738 ◽  
Author(s):  
M Nakamura ◽  
M Endo ◽  
K Murakami ◽  
H Konno ◽  
K Fujihara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Neuromyelitis Optica ◽  
White Matter Lesion ◽  
Transverse Myelitis ◽  
Cerebral Lesion ◽  
Tissue Destruction ◽  
Consciousness Disturbance ◽  
Frontal White Matter ◽  
Inflammatory Changes

We report a case of neuromyelitis optica (NMO) with a large cerebral lesion. The patient had an episode of fever and consciousness disturbance with a tumefactive frontal white matter lesion at age 43, and then repeated bilateral optic neuritis and transverse myelitis until she died at age 63. Histopathological examinations revealed that marked tissue destruction, cavities and inflammatory changes typical of NMO were seen in the cerebrum as well as the optic nerves and spinal cord. This is the first autopsied case of NMO with a tumefactive cerebral lesion that later became cavitary.

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