scholarly journals Vaccine Induced Acute Transverse Myelitis: A Case Report

2016 ◽  
Vol 13 (2) ◽  
pp. 89-91 ◽  
Author(s):  
Avinash Chandra ◽  
Reema Rajbhandari ◽  
Samir Acharya ◽  
Priya Gurung ◽  
Basant Pant
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Adverse Reactions ◽  
Transverse Myelitis ◽  
Active Immunization ◽  
Acute Transverse Myelitis ◽  
Autoimmune Phenomenon ◽  
Improve Accuracy ◽  
Post Traumatic ◽  
Post Infectious

Acute transverse myelitis is a focal infl ammatory disorder of the spinal cord. One of the main etiologic factors include, multiple sclerosis, post-infectious and post-traumatic events although autoimmune phenomenon is the most common cause. Transverse Myelitis (TM) due to etiology other than Multiple Sclerosis has shown spinal cord involvement of two or more segments. Annually millions of active immunization with vaccines is carried out globally with few transverse myelitis caused because of the adverse reactions due to these vaccinations. In order to improve accuracy of reporting, research and diagnosis, the Transverse Myelitis Consortium Working Group (TMCWG) have produced criteria for the diagnosis of ATM. Here we report a case of TM in adult, diagnosed as TM consistent with the TMCWG criteria and probably this is the first ever been reported case from Nepal. Nepal Journal of Neuroscience. Vol. 13, No. 2, 2016, Page: 89-91 

scholarly journals Covid-19 post-infectious acute transverse myelitis responsive to corticosteroid therapy: report of two clinical cases

2021 ◽  
Author(s):  
Thaís de Maria Frota Vasconcelos ◽  
Danilo Nunes Oliveira ◽  
Glauber de Menezes Ferreira ◽  
Fabrícia Carneiro Torres ◽  
José Daniel Vieira de Castro ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Transverse Myelitis ◽  
Acute Transverse Myelitis ◽  
Post Infectious ◽  
Clinical Cases

Acute Transverse Myelitis Associated with COVID-19 vaccine: A Case Report

2021 ◽  
Vol 12 (3) ◽  
pp. 2083-2087
Author(s):  
Ali Alshararni
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Acute Inflammation ◽  
Transverse Myelitis ◽  
Preventive Measure ◽  
Mri Findings ◽  
Dorsal Spinal Cord ◽  
Lumbosacral Spinal Cord ◽  
Acute Transverse Myelitis ◽  
Magnetic Resonance Imaging Mri

The case report demonstrates the issue of Khalid Ali, who is a citizen of Yamen, explicitly living in Saudi Arabia. He is 38 years, weighs 82kgs, and of 162 cm in height. He is a sales professional and married with two kids. Khalid Ali has been living healthy until two years ago when he started experiencing pains in his lower extremities accompanied by numbness. He was treated, and everything went back to normal until soon when the case came back after the administration of the Pfizer vaccine as a preventive measure for COVID-19 disease. The consequence of the administration of the Pfizer vaccine resulted in severe pain and weaknesses in his legs and severe headache on the second day, which resulted in him being put on an ICU after 48 hours since he was almost paralyzed. A series of tests were conducted on him, including magnetic resonance imaging (MRI), hematology, and biochemistry which involved Cerebrospinal Fluid (CSF) protein test. MRI findings were significant since they indicated acute inflammation on the spine observed on the dorsal spinal cord with contrast and lumbosacral spinal cord. All the hematology tests turned out to be expected. Biochemistry conducted tests were similarly standard except for CSF protein which was highly abnormal. The combination of the high abnormal CSF protein test and acute inflammation of the spine observed from the MRI findings were confirmed evidence of acute transverse myelitis as a result of the administration of the Pfizer vaccine.

A Case of Acute Transverse Myelitis Affecting the Entire Length of the Spinal Cord

1997 ◽  
Vol 37 (4) ◽  
pp. 247-248 ◽  
Author(s):  
Tomihiro Imai ◽  
Hiroyuki Matsumoto ◽  
Yukiko Ohkubo ◽  
Hirohiko Shizukawa ◽  
Susumu Chiba ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transverse Myelitis ◽  
Entire Length ◽  
Acute Transverse Myelitis

NMO-IgG and Devic's neuromyelitis optica: a French experience

2008 ◽  
Vol 14 (4) ◽  
pp. 440-445 ◽  
Author(s):  
Romain Marignier ◽  
Jérôme De Sèze ◽  
Sandra Vukusic ◽  
Françoise Durand-Dubief ◽  
Hélène Zéphir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Staining Pattern ◽  
Transverse Myelitis ◽  
Group 4 ◽  
Acute Transverse Myelitis ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Devic’S Neuromyelitis Optica ◽  
Group 1

Background A serum autoantibody biomarker, NMO-IgG has been recently described in patients with Devic's neuromyelitis optica (DNMO) and so called `high-risk' patients for this disease. Our objectives were to replicate the test and to assess its usefulness. Methods Indirect immunofluorescence with a substrate of adult rat cerebellum and midbrain was used to identify the distinctive NMO-IgG staining pattern. We tested masked sera from 26 patients with DNMO (group 1), 21 patients with idiopathic acute transverse myelitis (ATM) (group 2), 21 patients with bilateral and/or recurrent idiopathic optic neuritis (group 3), 52 patients with classical multiple sclerosis (MS) (group 4), 36 patients with HTLV-1 infection (group 5) and 7 patients with miscellaneous disorders (group 6). Results We identified a vascular staining pattern typical of NMO-IgG. This particular staining was observed in 14/26 samples in group 1, 7/21 in group 2 (positive only in longitudinally extensive acute transverse myelitis: 7/13), 4/21 in group 3 (with bilateral loss of vision in all seropositive cases), 5/52 in group 4 (none of them suggestive of DNMO), 0/36 in group 5 and 0/7 in group 6. Sensitivity of the test was 54% considering detection of DNMO (group 1), and specificity was respectively 94% and 90% when considering groups 4, 5 and 6 altogether or group 4 of MS patients only. Conclusion Detection of NMO-IgG is contributory to the distinction of DNMO and `DNMO high-risk' syndromes from MS. This test may allow earlier diagnosis and help therapeutic decisions. Multiple Sclerosis 2008; 14: 440—445. http://msj.sagepub.com

Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies

2021 ◽  
Vol 14 (1) ◽  
pp. e238992
Author(s):  
Katherine Thornley ◽  
Carlo Canepa
Keyword(s):  
Spinal Cord ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Sensory Level ◽  
Mri Scan ◽  
Acute Transverse Myelitis ◽  
Longitudinal Extensive Transverse Myelitis ◽  
Oral Steroids ◽  
Extensive Transverse Myelitis

An 80-year-old, previously healthy patient presents with acute transverse myelitis with sensory level at T8. The MRI scan of the spinal cord showed longitudinal extensive transverse myelitis, and she tested positive for aquaporin 4 antibodies in serum. She received treatment with intravenous and oral steroids, with no improvement and then underwent plasma exchange. She was then started on azathioprine for prevention of relapses, while continuing physiotherapy and occupational therapy. Eventually, she was transferred to a specialised spinal cord centre for long-term rehabilitation.

Neuromyelitis Optica

2017 ◽  
Author(s):  
Teri L. Schreiner ◽  
Jeffrey L. Bennett
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Water Channel ◽  
Transverse Myelitis ◽  
Inflammatory Disorder ◽  
The Central Nervous System

Neuromyelitis optica (NMO), or Devic’s disease is an inflammatory disorder of the central nervous system that preferentially affects the optic nerves and spinal cord. Initially considered a variant of multiple sclerosis (MS), NMO is now clearly recognized to have distinct clinical, radiographic, and pathologic characteristics. Historically, the diagnosis of NMO required bilateral optic neuritis and transverse myelitis; however, the identification of a specific biomarker, NMO-IgG, an autoantibody against the aquaporin-4 (AQP4) water channel, has broadened NMO spectrum disease to include patients with diverse clinical and radiographic presentations. This chapter addresses the diagnosis, pathophysiology, and management of the disease.

scholarly journals Decrease in Multiple Sclerosis with Acute Transverse Myelitis in Japan.

1999 ◽  
Vol 188 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Ichiro Nakashima ◽  
Kazuo Fujihara ◽  
Sadao Takase ◽  
Yasuto Itoyama
Keyword(s):  
Multiple Sclerosis ◽  
Transverse Myelitis ◽  
Acute Transverse Myelitis

scholarly journals Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report

2003 ◽  
Vol 61 (2A) ◽  
pp. 265-268 ◽  
Author(s):  
Luiz Fernando Fonseca ◽  
Thelma Ribeiro Noce ◽  
Maria Letícia Gambogi Teixeira ◽  
Antônio Lúcio Teixeira Jr ◽  
Marco Aurélio Lana-Peixoto
Keyword(s):  
Spinal Cord ◽  
Hepatitis B ◽  
Transverse Myelitis ◽  
Acute Onset ◽  
Clinical Syndrome ◽  
Hepatitis B Vaccination ◽  
Sensory Level ◽  
Resonance Imaging ◽  
Acute Transverse Myelitis ◽  
Viral Respiratory

Acute transverse myelitis is an acute inflammatory process of the spinal cord and it is a rare clinical syndrome in childhood. In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination. Magnetic resonance imaging of the spinal cord disclosed signal-intensity abnormalities from C4 to C3. A diagnosis of acute transverse myelitis was made and the patient was treated with IV methylprednisolone and IV immunoglobulin. The child had a fair outcome despite of the very acute course of the disease and the presence of a cervical sensory level which usually harbor a poor prognosis.

scholarly journals Acute Flaccid Myelitis in COVID-19

2020 ◽  
Vol 6 (3) ◽  
pp. 20200098
Author(s):  
Mohamed Abdelhady ◽  
Ahmed Elsotouhy ◽  
Surjith Vattoth
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Case Reports ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Imaging Findings ◽  
Metabolic Complications ◽  
Acute Flaccid Myelitis ◽  
Post Infectious ◽  
Spinal Cord Imaging

Spinal cord imaging findings in COVID-19 are evolving with the increasing frequency of neurological symptoms among COVID-19 patients. Several mechanisms are postulated to be the cause of central nervous system affection including direct virus neuroinvasive potential, post infectious secondary immunogenic hyperreaction, hypercoagulability, sepsis and possible vasculitis as well as systemic and metabolic complications associated with critical illness. Only a few case reports of spinal cord imaging findings are described in COVID-19, which include transverse myelitis, acute disseminated encephalomyelitis and post-infectious Guillain Barre’ syndrome. We are describing a case of myelitis which, to the best of our knowledge, is the first reported case of myelitis in COVID-19.

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