Study of photodynamic activity of Au@SiO2 core-shell nanoparticles in vitro

2016 ◽  
Vol 63 ◽  
pp. 317-322 ◽  
Author(s):  
K.S. Meena ◽  
K.I. Dhanalekshmi ◽  
K. Jayamoorthy
Keyword(s):  
Core Shell ◽  
Shell Nanoparticles ◽  
Photodynamic Activity ◽  
Core Shell Nanoparticles

Photodynamic activity and DNA binding studies of Pd@SiO2 core-shell nanoparticles in vitro

2019 ◽  
Vol 26 ◽  
pp. 79-84 ◽  
Author(s):  
K.I. Dhanalekshmi ◽  
K. Sangeetha ◽  
K.S. Meena ◽  
P. Magesan ◽  
A. Manikandan ◽  
...  
Keyword(s):  
Dna Binding ◽  
Core Shell ◽  
Binding Studies ◽  
Shell Nanoparticles ◽  
Photodynamic Activity ◽  
Dna Binding Studies ◽  
Core Shell Nanoparticles

PEG-Iron Oxide Core-Shell Nanoparticles: In situ Synthesis and In vitro Biocompatibility Evaluation for Potential T2-MRI Applications

2020 ◽  
Vol 10 (4) ◽  
pp. 1107-1120
Author(s):  
Karina Almeida Barcelos ◽  
Marli Luiza Tebaldi ◽  
Eryvaldo Socrates Tabosa do Egito ◽  
Nádia Miriceia Leão ◽  
Daniel Cristian Ferreira Soares
Keyword(s):  
Iron Oxide ◽  
In Situ Synthesis ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
In Vitro Biocompatibility ◽  
Iron Oxide Core ◽  
Core Shell Nanoparticles ◽  
T2 Mri

scholarly journals Albumin-Albumin/Lactosylated Core-Shell Nanoparticles: Therapy to Treat Hepatocellular Carcinoma for Controlled Delivery of Doxorubicin

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5432
Author(s):  
Nayelli Guadalupe Teran-Saavedra ◽  
Jose Andrei Sarabia-Sainz ◽  
Enrique Fernando Velázquez-Contreras ◽  
Gabriela Ramos-Clamont Montfort ◽  
Martín Pedroza-Montero ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Side Effects ◽  
Hepg2 Cells ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Human Liver Cancer ◽  
Systemic Side Effects ◽  
Human Liver Cancer Cells ◽  
Core Shell Nanoparticles

Doxorubicin (Dox) is the most widely used chemotherapeutic agent and is considered a highly powerful and broad-spectrum for cancer treatment. However, its application is compromised by the cumulative side effect of dose-dependent cardiotoxicity. Because of this, targeted drug delivery systems (DDS) are currently being explored in an attempt to reduce Dox systemic side-effects. In this study, DDS targeting hepatocellular carcinoma (HCC) has been designed, specifically to the asialoglycoprotein receptor (ASGPR). Dox-loaded albumin-albumin/lactosylated (core-shell) nanoparticles (tBSA/BSALac NPs) with low (LC) and high (HC) crosslink using glutaraldehyde were synthesized. Nanoparticles presented spherical shapes with a size distribution of 257 ± 14 nm and 254 ± 14 nm, as well as an estimated surface charge of −28.0 ± 0.1 mV and −26.0 ± 0.2 mV, respectively. The encapsulation efficiency of Dox for the two types of nanoparticles was higher than 80%. The in vitro drug release results showed a sustained and controlled release profile. Additionally, the nanoparticles were revealed to be biocompatible with red blood cells (RBCs) and human liver cancer cells (HepG2 cells). In cytotoxicity assays, Dox-loaded nanoparticles decrease cell viability more efficiently than free Dox. Specific biorecognition assays confirmed the interaction between nanoparticles and HepG2 cells, especially with ASGPRs. Both types of nanoparticles may be possible DDS specifically targeting HCC, thus reducing side effects, mainly cardiotoxicity. Therefore, improving the quality of life from patients during chemotherapy.

Facile Synthesis and In Vitro Biological Screening of Pd@SiO2 Core–Shell Nanoparticles

2019 ◽  
Vol 19 (6) ◽  
pp. 3536-3543 ◽  
Author(s):  
K Rajasekar ◽  
A Dinesh ◽  
M Durka ◽  
K Muthukumaravel
Keyword(s):  
Dna Binding ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Core Shell ◽  
Light Illumination ◽  
Shell Nanoparticles ◽  
The Core ◽  
Ft Ir ◽  
Core Shell Nanoparticles

In this study, semiconductor core–shell Pd@SiO2 nanoparticles (NPs) were prepared by Stober’s method. The prepared final products were characterized by XRD, FT-IR, SEM, HR-TEM and EDX techniques. Cell viability of Pd@SiO2 NPs against HeLa cell line was screened by MTT assay. The present study indicates that the core–shell Pd@SiO2 NPs are extremely stable along with very high photodynamic efficiency under LED light illumination. The antibacterial activities of core– shell Pd@SiO2 NPs were determined with Escherichia coli and Staphylococcus aureus by agar diffusion method. DNA binding affinity of the core–shell Pd@SiO2 NPs towards CT-DNA was also investigated. The observed results showed that SiO2 supported on the surface of Pd NPs not only prevented aggregation, but also proved the enhanced antimicrobial and DNA binding propensities than the free Pd NPs.

scholarly journals An in vitro and in vivo bio-interaction responses and biosafety evaluation of novel Au–ZnTe core–shell nanoparticles

2016 ◽  
Vol 5 (4) ◽  
pp. 1078-1089 ◽  
Author(s):  
R. Dunpall ◽  
N. Revaprasadu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapeutics ◽  
Surface Modifications ◽  
Core Shell ◽  
Support Surface ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Biosafety Evaluation

Novel gold–zinc telluride (Au–ZnTe) core–shell nanoparticles were synthesized to support surface modifications for enhanced drug delivery in cancer therapeutics.

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