Superparamagnetic iron oxide nanoparticles modified with dimyristoylphosphatidylcholine and their distribution in the brain after injection in the rat substantia nigra

The recent, fast development of nanotechnology is reflected in the medical sciences. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to their superparamagnetic properties, SPIONs have found application in Magnetic Resonance Imaging (MRI) and magnetic hyperthermia. Unlike bulk iron, SPIONs do not have remnant magnetization in the absence of the external magnetic field; therefore, a precise remote control over their action is possible. This makes them also useful as a component of the advanced drug delivery systems. Due to their easy synthesis, biocompatibility, multifunctionality, and possibility of further surface modification with various chemical agents, SPIONs could support many fields of medicine. SPIONs have also some disadvantages, such as their high uptake by macrophages. Nevertheless, based on the ongoing studies, they seem to be very promising in oncological therapy (especially in the brain, breast, prostate, and pancreatic tumors). The main goal of our paper is, therefore, to present the basic properties of SPIONs, to discuss their current role in medicine, and to review their applications in order to inspire future developments of new, improved SPION systems.

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The synthesis and characterization of glutathione-modified superparamagnetic iron oxide nanoparticles and their distribution in rat brains after injection in substantia nigra

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-018-6209-3 ◽

2018 ◽

Vol 30 (1) ◽

Cited By ~ 5

Author(s):

Guihua Han ◽

Baolin Zhang ◽

Hao Zhang ◽

Dong Han ◽

Jie Tan ◽

...

Keyword(s):

Iron Oxide ◽

Substantia Nigra ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Synthesis And Characterization ◽

Oxide Nanoparticles

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TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

Journal of Drug Discovery and Therapeutics ◽

10.32553/jddt.v6i10.444 ◽

2018 ◽

Vol 6 (10) ◽

Author(s):

Hosam Zaghloul ◽

Doaa A. Shahin ◽

Ibrahim El- Dosoky ◽

Mahmoud E. El-awady ◽

Fardous F. El-Senduny ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Cellular Uptake ◽

Superparamagnetic Iron Oxide ◽

Cyclin B1 ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Mcf7 Cells ◽

M Phase ◽

The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

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Novel Superparamagnetic Iron Oxide Nanoparticles for a Multifunctional Nanomedicine Platform

10.1557/proc-1140-hh05-11 ◽

2008 ◽

Cited By ~ 1

Author(s):

Oleh Taratula ◽

Ronak Savla ◽

Ipsit Pandya ◽

Andrew Wang ◽

Tamara Minko ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles

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Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681208666181015120346 ◽

2020 ◽

Vol 10 (2) ◽

pp. 166-174

Author(s):

Mehdi Khoshneviszadeh ◽

Sarah Zargarnezhad ◽

Younes Ghasemi ◽

Ahmad Gholami

Keyword(s):

Iron Oxide ◽

Amino Acid ◽

Magnetic Nanoparticles ◽

Iron Oxide Nanoparticles ◽

Surface Coating ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Surface Charges ◽

Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

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Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles

Acta Biomaterialia ◽

10.1016/j.actbio.2021.07.027 ◽

2021 ◽

Author(s):

Zewei Zhuo ◽

Jinghua Wang ◽

Yujun Luo ◽

Ruijie Zeng ◽

Chen Zhang ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Extracellular Vesicle ◽

Delivery Systems ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles

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Phosphotungstic acid impregnated niobium coated superparamagnetic iron oxide nanoparticles as recyclable catalyst for selective isomerization of terpenes

RSC Advances ◽

10.1039/d1ra00012h ◽

2021 ◽

Vol 11 (23) ◽

pp. 14203-14212

Author(s):

Luccas Lossano Name ◽

Sergio Hiroshi Toma ◽

Helton Pereira Nogueira ◽

Luis Humberto Avanzi ◽

Rafael dos Santos Pereira ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Conversion Efficiency ◽

Phosphotungstic Acid ◽

Superparamagnetic Iron Oxide ◽

Recyclable Catalyst ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetically Recyclable Catalyst

Conversion efficiency as high as 80–100% and 50% selectivity for camphene and limonene was achieved with low production of polymeric byproducts (18–28%), using a new magnetically recyclable catalyst – SPION-Nb30@HPW.

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