The stimuli-responsive properties of doxorubicin adsorbed onto bimetallic Au@Pd nanodendrites and its potential application as drug delivery platform

2020 ◽  
Vol 110 ◽  
pp. 110696 ◽  
Author(s):  
Adewale O. Oladipo ◽  
Thabo T.I. Nkambule ◽  
Bhekie B. Mamba ◽  
Titus A.M. Msagati
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Stimuli Responsive ◽  
Delivery Platform

scholarly journals Thermo-activatable PNIPAM-functionalized lanthanide-doped upconversion luminescence nanocomposites used for in vitro imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (80) ◽  
pp. 50643-50647 ◽  
Author(s):  
Po Li ◽  
Li Liu ◽  
Jing Zhou ◽  
Li Zhao ◽  
Haiming Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Therapeutic Effect ◽  
Potential Application ◽  
Cell Imaging ◽  
Upconversion Luminescence ◽  
Stimuli Responsive ◽  
Great Potential Application

Stimuli-responsive nanocomposite has a great potential application for cell imaging, drug delivery, and improving therapeutic effect.

Charge reversal induced colloidal hydrogel acts as a multi-stimuli responsive drug delivery platform for synergistic cancer therapy

2019 ◽  
Vol 6 (4) ◽  
pp. 711-716 ◽  
Author(s):  
Gang He ◽  
Sheng Chen ◽  
Yunjun Xu ◽  
Zhaohua Miao ◽  
Yan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Gelatin Nanoparticles ◽  
Charge Reversal ◽  
Delivery Platform ◽  
A Charge

A charge reversal induced colloidal hydrogel composed of amphoteric gelatin nanoparticles (Gela NPs) and melanin-like polydopamine nanoparticles (PDA NPs) was developed for synergistic cancer therapy.

scholarly journals Label-free characterization of organic nanocarriers reveals persistent single molecule cores for hydrocarbon sequestration

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Terry McAfee ◽  
Thomas Ferron ◽  
Isvar A. Cordova ◽  
Phillip D. Pickett ◽  
Charles L. McCormick ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Single Molecule ◽  
New Technologies ◽  
X Rays ◽  
Label Free ◽  
Stimuli Responsive ◽  
Local Environments ◽  
Delivery Platform ◽  
And Function

AbstractSelf-assembled molecular nanostructures embody an enormous potential for new technologies, therapeutics, and understanding of molecular biofunctions. Their structure and function are dependent on local environments, necessitating in-situ/operando investigations for the biggest leaps in discovery and design. However, the most advanced of such investigations involve laborious labeling methods that can disrupt behavior or are not fast enough to capture stimuli-responsive phenomena. We utilize X-rays resonant with molecular bonds to demonstrate an in-situ nanoprobe that eliminates the need for labels and enables data collection times within seconds. Our analytical spectral model quantifies the structure, molecular composition, and dynamics of a copolymer micelle drug delivery platform using resonant soft X-rays. We additionally apply this technique to a hydrocarbon sequestrating polysoap micelle and discover that the critical organic-capturing domain does not coalesce upon aggregation but retains distinct single-molecule cores. This characteristic promotes its efficiency of hydrocarbon sequestration for applications like oil spill remediation and drug delivery. Such a technique enables operando, chemically sensitive investigations of any aqueous molecular nanostructure, label-free.

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

Sign in / Sign up

Export Citation Format

Share Document