Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis

2021 ◽  
Vol 124 ◽  
pp. 112072
Author(s):  
Swathi Nedunchezian ◽  
Parikshit Banerjee ◽  
Chih-Yun Lee ◽  
Su-Shin Lee ◽  
Che-Wei Lin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
3D Bioprinting ◽  
Adipose Stem Cell

scholarly journals Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)—An In Vivo Animal Trial

2021 ◽  
Vol 22 (1) ◽  
pp. 443
Author(s):  
Robert Köhnke ◽  
Marcus Oliver Ahlers ◽  
Moritz Alexander Birkelbach ◽  
Florian Ewald ◽  
Michael Krueger ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Medicinal Product ◽  
Temporomandibular Joint ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Advanced Therapy Medicinal Product ◽  
Animal Trial ◽  
Advanced Therapy ◽  
Temporomandibular Joint Osteoarthritis

Temporomandibular joint osteoarthritis (TMJ-OA) is a chronic degenerative disease that is often characterized by progressive impairment of the temporomandibular functional unit. The aim of this randomized controlled animal trial was a comparative analysis regarding the chondroregenerative potency of intra-articular stem/stromal cell therapy. Four weeks after combined mechanical and biochemical osteoarthritis induction in 28 rabbits, therapy was initiated by a single intra-articular injection, randomized into the following groups: Group 1: AB Serum (ABS); Group 2: Hyaluronic acid (HA); Group 3: Mesenchymal stromal cells (STx.); Group 4: Mesenchymal stromal cells in hyaluronic acid (HA + STx.). After another 4 weeks, the animals were euthanized, followed by histological examination of the removed joints. The histological analysis showed a significant increase in cartilage thickness in the stromal cell treated groups (HA + STx. vs. ABS, p = 0.028; HA + ST.x vs. HA, p = 0.042; STx. vs. ABS, p = 0.036). Scanning electron microscopy detected a similar heterogeneity of mineralization and tissue porosity in the subchondral zone in all groups. The single intra-articular injection of a stem cell containing, GMP-compliant advanced therapy medicinal product for the treatment of iatrogen induced osteoarthritis of the temporomandibular joint shows a chondroregenerative effect.

scholarly journals Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway

2017 ◽  
Vol 49 (1) ◽  
pp. e284-e284 ◽  
Author(s):  
You-Sun Kim ◽  
Ji-Young Kim ◽  
RyeonJin Cho ◽  
Dong-Myung Shin ◽  
Sei Won Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Adipose Stem Cell ◽  
Dependent Pathway

A Simple Method to Generate Adipose Stem Cell-Derived Neurons for Screening Purposes

2013 ◽  
Vol 51 (2) ◽  
pp. 274-281 ◽  
Author(s):  
Caterina Bossio ◽  
Rosa Mastrangelo ◽  
Raffaella Morini ◽  
Noemi Tonna ◽  
Silvia Coco ◽  
...  
Keyword(s):  
Stem Cell ◽  
Adipose Stem Cell ◽  
Simple Method

scholarly journals Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration

Biomaterials ◽  
2016 ◽  
Vol 89 ◽  
pp. 136-147 ◽  
Author(s):  
Amit K. Jha ◽  
Kevin M. Tharp ◽  
Shane Browne ◽  
Jianqin Ye ◽  
Andreas Stahl ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 13 ◽  
Cell Engraftment

scholarly journals PDGF enhances the protective effect of adipose stem cell-derived extracellular vesicles in a model of acute hindlimb ischemia

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Tatiana Lopatina ◽  
Enrica Favaro ◽  
Cristina Grange ◽  
Massimo Cedrino ◽  
Andrea Ranghino ◽  
...  
Keyword(s):  
Stem Cell ◽  
Protective Effect ◽  
Extracellular Vesicles ◽  
Hindlimb Ischemia ◽  
Adipose Stem Cell

Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing

2020 ◽  
Vol 17 (5) ◽  
pp. 1723-1733 ◽  
Author(s):  
Qijun Lv ◽  
Junfeng Deng ◽  
You Chen ◽  
Yizhen Wang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cutaneous Wound Healing ◽  
Adipose Stem Cell ◽  
Cutaneous Wound ◽  
Human Adipose Stem Cell
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