Bioresponsive starPEG-heparin hydrogel coatings on vascular stents for enhanced hemocompatibility

Author(s):  
Castro Johnbosco ◽  
Stefan Zschoche ◽  
Mirko Nitschke ◽  
Dominik Hahn ◽  
Carsten Werner ◽  
...  
1999 ◽  
Vol 36 (12) ◽  
pp. 909-1053
Author(s):  
M AMATTOS ◽  
K HODGSON ◽  
S HURLBERT ◽  
J HENRETTA ◽  
Y STERNBACH ◽  
...  
Keyword(s):  

2020 ◽  
Author(s):  
Weiliang Shi ◽  
Hongxia Li ◽  
Kellen Mitchell ◽  
Cheng Zhang ◽  
Tingzhun Zhu ◽  
...  

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 770
Author(s):  
Chen Pan ◽  
Yafeng Han ◽  
Jiping Lu

Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific research with more and more patients suffering from cardiovascular diseases. However, vascular stent implanted into vessels of patients often causes complications such as In-Stent Restenosis (ISR). The vascular stent is one of the sophisticated medical devices, a reasonable structure of stent can effectively reduce the complications. In this paper, we introduce the evolution, performance evaluation standards, delivery and deployment, and manufacturing methods of vascular stents. Based on a large number of literature pieces, this paper focuses on designing structures of vascular stents in terms of “bridge (or link)” type, representative volume unit (RVE)/representative unit cell (RUC), and patient-specific stent. Finally, this paper gives an outlook on the future development of designing vascular stents.


1990 ◽  
Vol 4 (6) ◽  
pp. 617-623 ◽  
Author(s):  
Hâkan Pärsson ◽  
Lars Norgren ◽  
Krasnodar Ivancev ◽  
Johan Thörne ◽  
Bo-Anders Jönsson

2017 ◽  
Author(s):  
Henry Oliver T. Ware ◽  
Adam C. Farsheed ◽  
Robert van Lith ◽  
Evan Baker ◽  
Guillermo Ameer ◽  
...  

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.


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