scholarly journals Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

Molecules ◽  
2022 ◽  
Vol 27 (1) ◽  
pp. 281
Author(s):  
Li Li ◽  
Dongyu Lei ◽  
Jiaojiao Zhang ◽  
Lu Xu ◽  
Jiashan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Disulfide Bonds ◽  
Intelligent System ◽  
Click Reaction ◽  
Drug Loading ◽  
Loading Capacity ◽  
Triggered Release ◽  
High Drug ◽  
Dual Responsive ◽  
High Drug Loading

Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (Glu-Cys-SA) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded Glu-Cys-SA hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

A novel composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan: preparation and application in drug delivery

2017 ◽  
Vol 5 (21) ◽  
pp. 3898-3906 ◽  
Author(s):  
Yong-Gang Zhang ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Tuan-Wei Sun
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Composite Scaffold ◽  
Drug Loading ◽  
Loading Capacity ◽  
Sustained Drug Release ◽  
High Drug ◽  
High Drug Loading

The composite scaffold comprising ultralong hydroxyapatite microtubes and chitosan with high drug loading capacity and sustained drug release properties has been successfully prepared.

Black phosphorus analogue tin sulfide nanosheets: synthesis and application as near-infrared photothermal agents and drug delivery platforms for cancer therapy

2018 ◽  
Vol 6 (29) ◽  
pp. 4747-4755 ◽  
Author(s):  
Zhongjian Xie ◽  
Dou Wang ◽  
Taojian Fan ◽  
Chenyang Xing ◽  
Zhongjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Near Infrared ◽  
Drug Loading ◽  
Black Phosphorus ◽  
Loading Capacity ◽  
Tin Sulfide ◽  
High Drug ◽  
High Drug Loading

Black phosphorus analogue tin sulfide nanosheets as photothermal and drug delivery agents with high drug loading capacity for cancer therapy.

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