Epigenetics of the Developing and Aging Brain: Mechanisms that Regulate Onset and Outcomes of Brain Reorganization

2021 ◽  
Author(s):  
Eliza R Bacon ◽  
Roberta Diaz Brinton
Keyword(s):  
Aging Brain ◽  
Brain Reorganization

Studying Multilingualism and Group Differences in Adult Communication

2010 ◽  
Vol 17 (3) ◽  
pp. 59-64
Author(s):  
Loraine K. Obler
Keyword(s):  
Older Adults ◽  
Research Center ◽  
Group Differences ◽  
Aging Brain

The focus of this article is on the study of bilingual and multilingual adults at the Howard Goodglass Aphasia Research Center and the Language in the Aging Brain Laboratory by Drs. Obler and Albert along with former students and colleagues. Summaries of studies examining research in healthy bilingual adults, healthy monolingual older adults, and monolingual and bilingual individuals with aphasia are presented.

Cortico-Subcortical Metabolic Changes in Aging Brain: A 18F FDG PET/CT Study

2014 ◽  
Vol 1 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Agostino Chiaravalloti ◽  
◽  
Paolo Abbatiello ◽  
Ferdinando Calabria ◽  
Barbara Palumbo ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Metabolic Changes ◽  
Aging Brain ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Chromosome Instability, Aging and Brain Diseases

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1256
Author(s):  
Ivan Y. Iourov ◽  
Yuri B. Yurov ◽  
Svetlana G. Vorsanova ◽  
Sergei I. Kutsev
Keyword(s):  
Brain Aging ◽  
Chromosome Instability ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Accelerated Aging ◽  
Brain Diseases ◽  
Aging Brain ◽  
Ontogenetic Changes ◽  
Health And Disease

Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood. Alternatively, CIN and aneuploidy (chromosomal loss/gain) syndromes exhibit accelerated aging phenotypes. Molecularly, cellular senescence, which seems to be mediated by CIN and aneuploidy, is likely to contribute to brain aging in health and disease. However, there is no consensus about the occurrence of CIN in the aging brain. As a result, the role of CIN/somatic aneuploidy in normal and pathological brain aging is a matter of debate. Still, taking into account the effects of CIN on cellular homeostasis, the possibility of involvement in brain aging is highly likely. More importantly, the CIN contribution to neuronal cell death may be responsible for neurodegeneration and the aging-related deterioration of the brain. The loss of CIN-affected neurons probably underlies the contradiction between reports addressing ontogenetic changes of karyotypes within the aged brain. In future studies, the combination of single-cell visualization and whole-genome techniques with systems biology methods would certainly define the intrinsic role of CIN in the aging of the normal and diseased brain.

scholarly journals The aging brain: sleep,the circadian clock and exercise

2021 ◽  
pp. 114563
Author(s):  
M. Panagiotou ◽  
S. Michel ◽  
J.H. Meijer ◽  
T. Deboer
Keyword(s):  
Circadian Clock ◽  
Aging Brain

scholarly journals Insights on supporting the aging brain microvascular endothelium

Aging Brain ◽  
2021 ◽  
Vol 1 ◽  
pp. 100009
Author(s):  
Nektarios Barabutis
Keyword(s):  
Aging Brain ◽  
Microvascular Endothelium
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