scholarly journals Metabolic alterations in corpus callosum may compromise brain functional connectivity in MTBI patients: An 1H-MRS study

2012 ◽  
Vol 509 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Brian Johnson ◽  
Kai Zhang ◽  
Michael Gay ◽  
Thomas Neuberger ◽  
Silvina Horovitz ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Corpus Callosum ◽  
1H Mrs ◽  
Metabolic Alterations ◽  
Brain Functional Connectivity

scholarly journals Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity

2020 ◽  
Vol 11 ◽  
Author(s):  
Adellah Sariah ◽  
Shuixia Guo ◽  
Jing Zuo ◽  
Weidan Pu ◽  
Haihong Liu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Betel Quid ◽  
Chronic Effects ◽  
Betel Quid Chewing ◽  
Brain Functional Connectivity ◽  
Acute And Chronic Effects

scholarly journals Developmental Heatmaps of Brain Functional Connectivity from Newborns to 6-year-olds

2021 ◽  
pp. 100976
Author(s):  
Haitao Chen ◽  
Janelle Liu ◽  
Yuanyuan Chen ◽  
Andrew Salzwedel ◽  
Emil Cornea ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Brain Functional Connectivity

scholarly journals Glutamate connectivity associations converge upon the salience network in schizophrenia and healthy controls

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Robert A. McCutcheon ◽  
Toby Pillinger ◽  
Maria Rogdaki ◽  
Juan Bustillo ◽  
Oliver D. Howes
Keyword(s):  
Functional Connectivity ◽  
Frontal Cortex ◽  
Network Connectivity ◽  
Resonance Spectroscopy ◽  
Salience Network ◽  
Healthy Controls ◽  
1H Mrs ◽  
Before And After ◽  
Functional Brain Networks ◽  
The Relationship

AbstractAlterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear. We used multimodal imaging to identify areas of convergence between the two systems. Two separate cohorts were examined, comprising 195 participants in total. All participants received resting state functional MRI to characterise functional brain networks and proton magnetic resonance spectroscopy (1H-MRS) to measure glutamate concentrations in the frontal cortex. Study A investigated the relationship between frontal cortex glutamate concentrations and network connectivity in individuals with schizophrenia and healthy controls. Study B also used 1H-MRS, and scanned individuals with schizophrenia and healthy controls before and after a challenge with the glutamatergic modulator riluzole, to investigate the relationship between changes in glutamate concentrations and changes in network connectivity. In both studies the network based statistic was used to probe associations between glutamate and connectivity, and glutamate associated networks were then characterised in terms of their overlap with canonical functional networks. Study A involved 76 individuals with schizophrenia and 82 controls, and identified a functional network negatively associated with glutamate concentrations that was concentrated within the salience network (p < 0.05) and did not differ significantly between patients and controls (p > 0.85). Study B involved 19 individuals with schizophrenia and 17 controls and found that increases in glutamate concentrations induced by riluzole were linked to increases in connectivity localised to the salience network (p < 0.05), and the relationship did not differ between patients and controls (p > 0.4). Frontal cortex glutamate concentrations are associated with inter-areal functional connectivity of a network that localises to the salience network. Changes in network connectivity in response to glutamate modulation show an opposite effect compared to the relationship observed at baseline, which may complicate pharmacological attempts to simultaneously correct glutamatergic and connectivity aberrations.

scholarly journals Effect of a One-Week Spiritual Retreat on Brain Functional Connectivity: A Preliminary Study

Religions ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 23
Author(s):  
Nancy A. Wintering ◽  
David B. Yaden ◽  
Christopher Conklin ◽  
Mahdi Alizadeh ◽  
Feroze B. Mohamed ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Parietal Lobe ◽  
Well Being ◽  
Posterior Cingulate Cortex ◽  
Spiritual Well Being ◽  
Spiritual Retreat ◽  
Baseline Evaluation ◽  
Preliminary Study ◽  
Brain Functional Connectivity ◽  
Spiritual Impact

Background: Many individuals participate in spiritual retreats to enhance their sense of spirituality or to improve their overall mental and spiritual well-being. We are not aware of any studies specifically evaluating changes in functional connectivity using functional magnetic resonance imaging (fMRI) in individuals undergoing an intense spiritual retreat program. The goal of this study was to determine whether such changes occur as a result of participating in the Spiritual Exercises of St. Ignatius. Methods: We conducted psychological and spiritual measures in conjunction with functional connectivity analysis of fMRI in 14 individuals prior to and following shortly after their participation in a one-week spiritual retreat. Results: Significant changes in functional connectivity were observed after the retreat program, compared to baseline evaluation, particularly in the posterior cingulate cortex, pallidum, superior frontal lobe, superior parietal lobe, superior and inferior temporal lobe, and the cerebellum. Significant changes in a variety of psychological and spiritual measures were identified as result of participation in the retreat. Conclusion: Overall, these preliminary findings suggest that this intensive spiritual retreat resulted in significant changes in brain functional connectivity, and warrants further investigation to evaluate the physiological, psychological, and spiritual impact of these changes.

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