Retinoic acid exerts neuroprotective effects against focal cerebral ischemia by preventing apoptotic cell death

2021 ◽  
pp. 135979
Author(s):  
Ju-Bin Kang ◽  
Dong-Ju Park ◽  
Murad-Ali Shah ◽  
Phil-Ok Koh
Keyword(s):  
Cell Death ◽  
Retinoic Acid ◽  
Cerebral Ischemia ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Apoptotic Cell Death ◽  
Neuroprotective Effects

The protective effect of lipophilic iron chelator 2, 2′-dipyridyl after focal cerebral ischemia closely correlates with limitation of apoptotic cell death

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S482-S482
Author(s):  
Michaël C Van Hoecke ◽  
Anne Prigent-Tessier ◽  
Philippe E Garnier ◽  
Christine Marie ◽  
Alain Beley
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Iron Chelator ◽  
Apoptotic Cell Death

Potassium aspartate attenuates apoptotic cell death after focal cerebral ischemia in rats

2013 ◽  
Vol 3 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Yi Gu ◽  
Yumei Zhao ◽  
Lei Gong ◽  
Yongjun Wang ◽  
Yazhuo Zhang
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Apoptotic Cell Death

Evidence for apoptotic cell death in the choroid plexus following focal cerebral ischemia

1996 ◽  
Vol 207 (2) ◽  
pp. 113-116 ◽  
Author(s):  
F. Gillardon ◽  
C. Lenz ◽  
W. Kuschinsky ◽  
Manfred Zimmermann
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Choroid Plexus ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Apoptotic Cell Death

Ischemic intensity influences the distribution of delayed infarction and apoptotic cell death following transient focal cerebral ischemia in rats

2002 ◽  
Vol 956 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Seung-Hoon Lee ◽  
Manho Kim ◽  
Young-Ju Kim ◽  
Young-A Kim ◽  
Je-Geun Chi ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Apoptotic Cell Death ◽  
Transient Focal Cerebral Ischemia

Abstract TMP3: Low Concentration Normobaric Oxygen Enhanced Therapeutic Effect of Mild Hypothermia or Ethanol Through a Reduction in Apoptosis

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kaiyin Liu ◽  
Lipeng Cai ◽  
Changya Peng ◽  
Xiaokun Geng ◽  
Xunming Ji ◽  
...  
Keyword(s):  
Cell Death ◽  
Therapeutic Effect ◽  
Mild Hypothermia ◽  
Apoptotic Cell ◽  
Artery Occlusion ◽  
Apoptotic Cell Death ◽  
Tissue Type ◽  
Neuroprotective Effects ◽  
Normobaric Oxygen ◽  
Low Concentration

Introduction: Neuroprotective effects of normobaric oxygen (NBO) and ethanol (EtOH) has been shown. In a clinically relevant autologous embolus rat stroke model in which reperfusion was established by tissue-type plasminogen activator (rt-PA), the present study further evaluated whether low concentration NBO enhanced therapeutic effect of mild hypothermia (Hypo) or EtOH through a reduction in apoptosis and whether EtOH can substitute for hypothermia. Hypothesis: Hypo and EtOH has been shown to have neuroprotective effects through similar mechanisms. We assessed the hypothesis that low concentration NBO, whose neuroprotective effects are currently debated, has benefit in our stroke models, and we further assessed the hypothesis that EtOH can substitute for Hypo in the presence of tPA and NBO. Methods: At 1 hour of middle cerebral artery occlusion (MCAO) by an autologous embolus, rats (96 total, 12 in each treatment group) received rt-PA and other treatments of either EtOH (1.0 g/kg) or Hypo (33 °C for 3 hours) in combination with NBO (60% for 3 hours). Apoptotic cell death was measured by ELISA. Western immunoblotting was performed for pro- (AIF, Caspase-3, Bax) and anti-apoptotic (Bcl-2) protein expression at 3 and 24 hours of reperfusion. Results: Compared to ischemic rats treated only with rt-PA, animals with NBO, hypothermia or EtOH had significantly reduced apoptotic cell death by 32.5%, 43.1% and 36.0% respectively. However, combination therapy that included NBO+EtOH or NBO+Hypo with rt-PA exhibited a much larger decline (p<0.01) in the cell death by 71.1% and 73.6%, respectively. Similarly, NBO+EtOH or NBO+Hypo treatment in addition to rt-PA enhanced beneficial effects on both pro- and anti-apoptotic protein expressions as compared to other options. Conclusions: Neuroprotection after reperfusion with rt-PA in ischemic stroke induced by thromboembolism are enhanced by combination treatment with either EtOH or Hypo in the presence of 60% NBO through reduced apoptosis. Since the effects produced by EtOH and Hypo are comparable, their mechanism of action may not only be similar but also could be interchangeable. Since EtOH administration does not lead to temperature decrease, EtOH may a better alternative than Hypo.

Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells

Life Sciences ◽  
2014 ◽  
Vol 109 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Doo Jin Choi ◽  
Sun-Lim Kim ◽  
Ji Won Choi ◽  
Yong Il Park
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Neuroprotective Effects ◽  
Corn Silk
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