Maintenance of long-term memory requires persistent regulation of gene expression

2011 ◽  
Vol 71 ◽  
pp. e90
Author(s):  
Yukinori Hirano ◽  
Minoru Saitoe
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

Cell ◽  
2002 ◽  
Vol 111 (4) ◽  
pp. 483-493 ◽  
Author(s):  
Zhonghui Guan ◽  
Maurizio Giustetto ◽  
Stavros Lomvardas ◽  
Joung-Hun Kim ◽  
Maria Concetta Miniaci ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synaptic Plasticity ◽  
Chromatin Structure ◽  
Regulation Of Gene Expression ◽  
Long Term Memory ◽  
Term Memory ◽  
Bidirectional Regulation

scholarly journals Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Lijie Hao ◽  
Zhuoqin Yang
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Regulation Of Gene Expression ◽  
Network Motif ◽  
Noncoding Rnas ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory ◽  
Motif Model

Noncoding RNAs such as miRNAs and piRNAs have long-lasting effects on the regulation of gene expression involved in long-term synaptic changes. To characterize gene regulation mediated by small noncoding RNAs associated with long-term memory in Aplysia, we consider two noncoding RNAs stimulated by 5-HT into a gene regulatory network motif model, including miR-124 that binds to and inhibits the mRNA of CREB1 and piR-F that facilitates serotonin-dependent DNA methylation to lead to repression of CREB2. Codimension-1 and -2 bifurcation analyses of 5-HT regulating both miR-124 and piR-F and a negative feedback strength for oscillation reveal rich dynamical properties of bistability and oscillations robust to variations in all other parameters. More importantly, we verify three stimulus protocols of 5-HT in experiments by our model and find that application of five pulses of 5-HT leads to a transient decrease of miR-124 but increase of piR-F concentrations, which matters sustained high level of CREB1 concentration associated with long-term memory. Furthermore, we perform bifurcation analyses for the concentrations of miR-124 and piR-F as two parameters to explore dynamical mechanisms underlying the epigenetic regulation in long-term memory formation. This study provides insights into revealing regulatory roles of epigenetic changes in gene expression involving noncoding RNAs associated with synaptic plasticity.

scholarly journals Identification of Gene Expression Changes Associated With Long-Term Memory of Courtship Rejection in Drosophila Males

2012 ◽  
Vol 2 (11) ◽  
pp. 1437-1445 ◽  
Author(s):  
Ari Winbush ◽  
Danielle Reed ◽  
Peter L. Chang ◽  
Sergey V. Nuzhdin ◽  
Lisa C. Lyons ◽  
...  
Keyword(s):  
Gene Expression ◽  
Long Term Memory ◽  
Term Memory

scholarly journals The CBP KIX domain regulates long-term memory and circadian activity

BMC Biology ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Snehajyoti Chatterjee ◽  
Christopher C. Angelakos ◽  
Ethan Bahl ◽  
Joshua D. Hawk ◽  
Marie E. Gaine ◽  
...  
Keyword(s):  
Gene Expression ◽  
Morris Water Maze ◽  
Water Maze ◽  
Long Term Memory ◽  
Circadian Activity ◽  
Term Memory ◽  
Circadian Genes ◽  
Domain Protein ◽  
Kix Domain

Abstract Background CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes. Identifying specific domain functions for multi-domain proteins is essential to understand processes such as cognitive function and circadian clocks. We investigated the function of the CBP KIX domain in hippocampal memory and gene expression using CBPKIX/KIX mice with mutations that prevent phospho-CREB (Ser133) binding. Results We found that CBPKIX/KIX mice were impaired in long-term memory, but not learning acquisition or short-term memory for the Morris water maze. Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice. Given our finding that the CBP KIX domain was important for transcription of circadian genes, we profiled circadian activity and phase resetting in CBPKIX/KIX mice. CBPKIX/KIX mice exhibited delayed activity peaks after light offset and longer free-running periods in constant dark. Interestingly, CBPKIX/KIX mice displayed phase delays and advances in response to photic stimulation comparable to wildtype littermates. Thus, this work delineates site-specific regulation of the circadian clock by a multi-domain protein. Conclusions These studies provide insight into the significance of the CBP KIX domain by defining targets of CBP transcriptional co-activation in memory and the role of the CBP KIX domain in vivo on circadian rhythms. Graphical abstract

scholarly journals Genetic signatures of memories

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Vivek Sagar ◽  
Thorsten Kahnt
Keyword(s):  
Gene Expression ◽  
Long Term Memory ◽  
Brain Areas ◽  
Negative Experiences ◽  
Term Memory ◽  
Genetic Signatures

Memorable positive and negative experiences produce different profiles of gene expression in brain areas associated with long-term memory.

scholarly journals The CBP KIX domain regulates long-term memory and circadian activity

2020 ◽  
Author(s):  
Snehajyoti Chatterjee ◽  
Christopher C. Angelakos ◽  
Ethan Bahl ◽  
Joshua D. Hawk ◽  
Marie E. Gaine ◽  
...  
Keyword(s):  
Gene Expression ◽  
Target Genes ◽  
Long Term Memory ◽  
Creb Binding Protein ◽  
Circadian Activity ◽  
Specific Domain ◽  
Term Memory ◽  
Circadian Genes ◽  
Kix Domain

AbstractCREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors. Identifying specific domain functions for multi-action proteins is essential to understand processes necessary for healthy living including cognitive function and a robust circadian clock. We investigated the function of the CBP KIX domain in hippocampal memory and gene expression using CBPKIX/KIX mice with mutations that prevent phospho-CREB (Ser133) binding. We found that CBPKIX/KIX mice were impaired in long-term, but not short-term spatial memory in the Morris water maze. Using an unbiased analysis of gene expression after training for hippocampus-dependent memory, we discovered dysregulation of CREB and CLOCK target genes and downregulation of circadian genes in CBPKIX/KIX mice. With our finding that the CBP KIX domain was important for transcription of circadian genes, we profiled circadian activity in CBPKIX/KIX mice. CBPKIX/KIX mice exhibited delayed activity peaks after light offset and longer free-running periods in constant dark, although phase resetting to light was comparable to wildtype. These studies provide insight into the significance of the CBP KIX domain by defining targets of CBP transcriptional co-activation in memory and the role of the CBP KIX domain in vivo on circadian rhythms.

scholarly journals The role of microRNAs in learning and long-term memory

2020 ◽  
Vol 24 (8) ◽  
pp. 885-896
Author(s):  
L. N. Grinkevich
Keyword(s):  
Cognitive Processes ◽  
Regulation Of Gene Expression ◽  
Memory Formation ◽  
Learning Ability ◽  
Long Term Memory ◽  
Term Memory ◽  
Microrna Biogenesis ◽  
The Brain

The mechanisms of long-term memory formation and ways to improve it (in the case of its impairment) remain an extremely difficult problem yet to be solved. Over the recent years, much attention has been paid to microRNAs in this regard. MicroRNAs are unique endogenous non-coding RNAs about 22 nucleotides in length; each can regulate translation of hundreds of messenger RNA targets, thereby controlling entire gene networks. MicroRNAs are widely represented in the central nervous system. A large number of studies are currently being conducted to investigate the role of microRNAs in the brain functioning. A number of microRNAs have been shown to be involved in the process of synaptic plasticity, as well as in the long-term memory formation. Disruption of microRNA biogenesis leads to significant cognitive dysfunctions. Moreover, impaired microRNA biogenesis is one of the causes of the pathogenesis of mental disorders, neurodegenerative illnesses and senile dementia, which are often accompanied by deterioration in the learning ability and by memory impairment. Optimistic predictions are made that microRNAs can be used as targets for therapeutic treatment and for diagnosing the above pathologies. The importance of applications related to microRNAs significantly raises interest in studying their functions in the brain. Thus, this review is focused on the role of microRNAs in cognitive processes. It describes microRNA biogenesis and the role of miRNAs in the regulation of gene expression, as well as the latest achievements in studying the functional role of microRNAs in learning and in long-term memory formation, depending on the activation or inhibition of their expression. The review presents summarized data on the effect of impaired microRNA biogenesis on long-term memory formation, including those associated with sleep deprivation. In addition, analysis is provided of the current literature related to the prospects of improving cognitive processes by influencing microRNA biogenesis via the use of CRISPR/Cas9 technologies and active mental and physical exercises.

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