Brain white matter damage in SCA1 and SCA2. An in vivo study using voxel-based morphometry, histogram analysis of mean diffusivity and tract-based spatial statistics

Background The pathogenesis and related factors of central nervous system abnormality in patients with type 2 diabetes mellitus (T2DM) have always been the focus of clinical research. Purpose To compare and analyze the area of white matter (WM) damage in patients with T2DM based on their level of hemoglobin A1C (HBA1c) and discuss any related factors. Material and Methods Based on their levels of HBA1c, 87 patients with T2DM were divided into three groups (Group B, C, or D), of which 29 non-diabetic volunteers served as the control group (Group A). DTI data analysis was based on tract-based spatial statistics (TBSS). The obtained parameters were compared among each group and the relevant clinical factors were analyzed. Results For age, sex, mini-mental state examination (MMSE), and Montreal Cognitive Assessment (MoCA) scores, there were no statistically significant differences among groups. For fractional anisotropy (FA) and radial diffusivity (RD) of WM, there were statistically significant differences ( P < 0.05, two-tailed, FWE corrected) in the local area of corpus callosum, corona radiate, superior longitudinal fasciculus, etc. Most of these were significantly correlated with body mass index (BMI), left systolic blood pressure (SBP_L), and β2 microglobulin. Conclusion Before the cognitive function was obviously impaired, abnormalities of FA and RD had been found in the corpus callosum, corona radiate, and upper fasciculus in patients with T2DM, which suggested that the damage mainly occurred in the myelin sheath of WM and may be related to systemic vascular damage.

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Tract-Based Spatial Statistics: Application to Mild Cognitive Impairment

BioMed Research International ◽

10.1155/2014/713079 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Yau-Yau Wai ◽

Wen-Chuin Hsu ◽

Hon-Chung Fung ◽

Jiann-Der Lee ◽

Hsiao-Lung Chan ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Apolipoprotein E ◽

Spatial Statistics ◽

Diffusion Tensor ◽

Cerebral White Matter ◽

Brain White Matter ◽

Amnestic Mci ◽

Tract Based Spatial Statistics

Rationale and Objectives. The primary objective of the current investigation was to characterize white matter integrity in different subtypes of mild cognitive impairment (MCI) using tract-based spatial statistics of diffusion tensor imaging.Materials and Methods. The study participants were divided into 4 groups of 30 subjects each as follows: cognitively healthy controls, amnestic MCI, dysexecutive MCI, and Alzheimer’s disease (AD). All subjects underwent a comprehensive neuropsychological assessment, apolipoprotein E genotyping, and 3-tesla MRI. The diffusion tensor was reconstructed and then analyzed using tract-based spatial statistics. The changes in brain white matter tracts were also examined according to the apolipoprotein Eε4 status.Results. Compared with controls, amnestic MCI patients showed significant differences in the cerebral white matter, where changes were consistently detectable in the frontal and parietal lobes. We found a moderate impact of the apolipoprotein Eε4 status on the extent of white matter disruption in the amnestic MCI group. Patients with AD exhibited similar but more extensive alterations, while no significant changes were observed in dysexecutive MCI patients.Conclusion. The results from this study indicate that amnestic MCI is the most likely precursor to AD as both conditions share significant white matter damage. By contrast, dysexecutive MCI seems to be characterized by a distinct pathogenesis.

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Concurrent decrease of brain white matter tracts' thicknesses and fractional anisotropy after antenatal hypoxia-ischemia detected with tract-based spatial statistics analysis

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.25407 ◽

2016 ◽

Vol 45 (3) ◽

pp. 829-838 ◽

Cited By ~ 2

Author(s):

Alexander Drobyshevsky

Keyword(s):

White Matter ◽

Fractional Anisotropy ◽

Spatial Statistics ◽

Statistics Analysis ◽

White Matter Tracts ◽

Antenatal Hypoxia ◽

Brain White Matter ◽

Hypoxia Ischemia ◽

Tract Based Spatial Statistics

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Age-related Differences in White Matter Integrity in Healthy Human Brain: Evidence from Structural Mri and Diffusion Tensor Imaging

Magnetic Resonance Insights ◽

10.4137/mri.s39666 ◽

2016 ◽

Vol 9 ◽

pp. MRI.S39666 ◽

Cited By ~ 7

Author(s):

Rishu Rathee ◽

V.P. Subramanyam Rallabandi ◽

Prasun K. Roy

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Spatial Statistics ◽

Diffusion Tensor ◽

Mean Diffusivity ◽

Middle Aged ◽

Healthy Human ◽

Aged Group ◽

Age Related ◽

Tract Based Spatial Statistics

The aim is to investigate the relationship between microstructural white matter (WM) diffusivity indices and macrostructural WM volume (WMV) among healthy individuals (20–85 years). Whole-brain diffusion measures were calculated from diffusion tensor imaging using FMRIB software library while WMV was estimated through voxel-based morphometry, and voxel-based analysis was carried out using tract-based spatial statistics. Our results revealed that mean diffusivity, axial diffusivity, and radial diffusivity had shown good correlation with WMV but not for fractional anisotropy (FA). Voxel-wise tract-based spatial statistics analysis for FA showed a significant decrease in four regions for middle-aged group compared to young-aged group, in 22 regions for old-aged group compared to middle-aged group, and in 26 regions for old-aged group compared to young-aged group ( P < 0.05). We found significantly lower WMV, FA, and mean diffusivity values in females than males and inverted-U trend for FA in males. We conclude differential age- and gender-related changes for structural WMV and WM diffusion indices.

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