Factors associated with brain white matter damage in type 2 diabetes mellitus: a tract-based spatial statistics study

2021 ◽  
pp. 028418512110564
Author(s):  
Zhi-Jun Guo ◽  
Qian Xu ◽  
Ze-Mei Bai ◽  
Yan Liu ◽  
Qiang Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
White Matter ◽  
Corpus Callosum ◽  
Spatial Statistics ◽  
Related Factors ◽  
Brain White Matter ◽  
Tract Based Spatial Statistics

Background The pathogenesis and related factors of central nervous system abnormality in patients with type 2 diabetes mellitus (T2DM) have always been the focus of clinical research. Purpose To compare and analyze the area of white matter (WM) damage in patients with T2DM based on their level of hemoglobin A1C (HBA1c) and discuss any related factors. Material and Methods Based on their levels of HBA1c, 87 patients with T2DM were divided into three groups (Group B, C, or D), of which 29 non-diabetic volunteers served as the control group (Group A). DTI data analysis was based on tract-based spatial statistics (TBSS). The obtained parameters were compared among each group and the relevant clinical factors were analyzed. Results For age, sex, mini-mental state examination (MMSE), and Montreal Cognitive Assessment (MoCA) scores, there were no statistically significant differences among groups. For fractional anisotropy (FA) and radial diffusivity (RD) of WM, there were statistically significant differences ( P < 0.05, two-tailed, FWE corrected) in the local area of corpus callosum, corona radiate, superior longitudinal fasciculus, etc. Most of these were significantly correlated with body mass index (BMI), left systolic blood pressure (SBP_L), and β2 microglobulin. Conclusion Before the cognitive function was obviously impaired, abnormalities of FA and RD had been found in the corpus callosum, corona radiate, and upper fasciculus in patients with T2DM, which suggested that the damage mainly occurred in the myelin sheath of WM and may be related to systemic vascular damage.

scholarly journals Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging

2021 ◽  
Vol 13 ◽  
Author(s):  
Li Huang ◽  
Qingqing Zhang ◽  
Tong Tang ◽  
Minguang Yang ◽  
Cong Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Corona Radiata

Aims: The study aimed to conduct a meta-analysis to determine the abnormalities of white matter in patients with type 2 diabetes mellitus (T2DM) by identifying the consistency of diffusion tensor imaging (DTI).Method: The literature for DTI comparing patients with T2DM with controls published before October 30, 2020, were reviewed in PubMed, Web of Science, Embase, CNKI, and Wan Fang databases. The meta-analysis was performed using the activation likelihood estimation (ALE) method, including 12 reports and 381 patients with T2DM.Results: The meta-analysis identified 10 white matter regions that showed a consistent reduction of fractional anisotropy (FA) in patients with T2DM, including genu of the corpus callosum, the body of corpus callosum, bilateral anterior corona radiata, bilateral superior corona radiata, bilateral cingulum, and bilateral superior fronto-occipital fasciculus.Conclusion: This study revealed the abnormal characteristics of white matter in T2DM, which would be helpful to understand the underlying neuropathological and physiological mechanisms of T2DM and provide evidence for clinical diagnosis and treatment.

scholarly journals Overexpression of microRNA-216a-3p Accelerates the Inflammatory Response in Cardiomyocytes in Type 2 Diabetes Mellitus by Targeting IFN-α2

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaomeng Liu ◽  
Yusong Zhang ◽  
Hongwei Liang ◽  
Yanchao Xu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cell Proliferation ◽  
Type 2 Diabetes Mellitus ◽  
Inflammatory Response ◽  
Major Complication ◽  
Cardiomyocyte Proliferation ◽  
Related Factors ◽  
Chronic Hyperglycemia

Background: Type 2 diabetes mellitus (T2DM) is a chronic, hyperglycemia-associated, metabolic disorder. Heart disease is a major complication of T2DM. The present study aimed to explore the effects of miR-216a-3p on cardiomyocyte proliferation, apoptosis, and inflammation in T2DM through the Toll-like receptor (TLR) pathway involving interferon-α2 (IFN-α2) mediation.Methods: T2DM was induced in rats by a high-fat diet, in combination with an intraperitoneal injection of low-dose streptozotocin. ELISAs were conducted to measure inflammatory-related factors in serum. Next, isolated cardiomyocytes were used in loss- and gain-of-function experiments, followed by MTT and flow cytometry assays, conducted to evaluate cell proliferation, cell cycle, and apoptosis.Results: Our results revealed an increase in the inflammatory response in T2DM rat models, accompanied by significantly increased expression of miR-216a-3p and TLR pathway-related genes. However, a decrease in the expression of IFN-α2 was observed. Moreover, the presence of an miR-216a-3p inhibitor and si-IFN-α2 increased the expression of TLR pathway-related genes and cell apoptosis, whereas cell proliferation was significantly decreased in the cardiomyocytes.Conclusion: We found that in T2DM, miR-216a-3p inhibited the proliferation and enhanced the apoptosis of cardiomyocytes and generated an inflammatory response through activation of the TLR pathway and targeting of IFN-α2.

scholarly journals Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice

Stroke ◽  
2018 ◽  
Vol 49 (12) ◽  
pp. 3039-3049 ◽  
Author(s):  
Yinghua Jiang ◽  
Ning Liu ◽  
Qingzhi Wang ◽  
Zhanyang Yu ◽  
Li Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ischemic Stroke ◽  
White Matter ◽  
Brain Infarction ◽  
White Matter Integrity ◽  
Fibroblast Growth Factor 21 ◽  
Neurological Outcomes

Background and Purpose— The complexity and heterogeneity of stroke, as well as the associated comorbidities, may render neuroprotective drugs less efficacious in clinical practice. Therefore, the development of targeted therapies to specific patient subsets has become a high priority in translational stroke research. Ischemic stroke with type 2 diabetes mellitus has a nearly double mortality rate and worse neurological outcomes. In the present study, we tested our hypothesis that rFGF21 (recombinant human fibroblast growth factor 21) administration is beneficial for improving neurological outcomes of ischemic stroke with type 2 diabetes mellitus. Methods— Type 2 diabetes mellitus db/db and nondiabetic genetic control db/+ mice were subjected into permanent focal ischemia of distal middle cerebral artery occlusion, we examined the effects of poststroke administration with rFGF21 in systemic metabolic disorders, inflammatory gatekeeper PPARγ (peroxisome proliferator-activated receptor γ) activity at 3 days, mRNA expression of inflammatory cytokines and microglia/macrophage activation at 7 days in the perilesion cortex, and last neurological function deficits, ischemic brain infarction, and white matter integrity up to 14 days after stroke of db/db mice. Results— After permanent focal ischemia, diabetic db/db mice presented confounding pathological features, including metabolic dysregulation, more severe brain damage, and neurological impairment, especially aggravated proinflammatory response and white matter integrity loss. However, daily rFGF21 treatment initiated at 6 hours after stroke for 14 days significantly normalized systemic metabolic disorders, rescued PPARγ activity decline, inhibited proinflammatory cytokine mRNA expression, and M1-like microglia/macrophage activation in the brain. Importantly, rFGF21 also significantly reduced white matter integrity loss, ischemic brain infarction, and neurological function deficits up to 14 days after stroke. The potential mechanisms of rFGF21 may in part consist of potent systematic metabolic regulation and PPARγ-activation promotion-associated antiproinflammatory roles in the brain. Conclusions— Taken together, these results suggest rFGF21 might be a novel and potent candidate of the disease-modifying strategy for treating ischemic stroke with type 2 diabetes mellitus.

scholarly journals Altered Hippocampal White Matter Connectivity in Type 2 Diabetes Mellitus and Memory Decrements

2016 ◽  
Vol 28 (3) ◽  
Author(s):  
F. C. G. van Bussel ◽  
W. H. Backes ◽  
P. A. M. Hofman ◽  
M. P. J. van Boxtel ◽  
M. T. Schram ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
White Matter ◽  
White Matter Connectivity

scholarly journals A narrative review of multimodal imaging of white matter lesions in type-2 diabetes mellitus

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Qian Tang ◽  
Siou Li ◽  
Zhengfang Yang ◽  
Meini Wu ◽  
Yongming Guo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
White Matter ◽  
Multimodal Imaging ◽  
White Matter Lesions ◽  
Narrative Review

Glycemic control may be influenced by climate changes in type 2 diabetes mellitus (T2DM)

1970 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Hiroshi Bando ◽  
Yoshikane Kato ◽  
Setsuko Kanazawa ◽  
Mayumi Tanaka ◽  
Etsuko Sueki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Seasonal Changes ◽  
Climate Changes ◽  
Related Factors ◽  
Hot Climate ◽  
Male Patients

Authors have continued clinical research on type 2 diabetes mellitus (T2DM). The trigger of this research was to make notice of elevated HbA1c of younger male diabetics for hot climate in the summer 2018. Enrolled subjects were 89 male patients with T2DM. Methods include the classification of 6 groups by the age, which are 21-40, 41-50, 51-60, 61-70, 71-80 and 81-90. HbA1c values in median were calculated for five seasons of 15 months. Basal HbA1c in 6 groups was 7.0%, 7.1%, 7.2%, 7.2%, 6.9% and 7.0%, respectively. Seasonal changes in HbA1c values are as follows: i) groups 21-50 showed highest in the summer, ii) groups 51-70 showed gradually decrease from winter to summer, iii) groups 71-90 showed gradually decrease from winter to autumn, and increase for winter. For seasonal HbA1c changes, influence of hot climate during from spring to summer may be involved for 21-50 years. More activity in spring to summer may be related for 51-70 years. Less exercise and more eating may be observed for 71-90 years. There are not enough analyze for related factors, then further study concerning various biomarkers would be expected.

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