Central Brain Neurons Expressing doublesex Regulate Female Receptivity in Drosophila

AbstractAnimal’s innate avoidance behavior is crucial for its survival. It subjects to modulation by environmental conditions in addition to the commanding sensorimotor transformation pathway. Although much has been known about the commanding neural basis, relatively less is known about how innate avoidance behavior is shaped by external conditions. Here in this paper, we report that Drosophila larvae showed stronger light avoidance at lower temperatures than at higher temperatures. Such negative regulation of light avoidance by temperature was abolished by blocking two pairs of central brain neurons, ACLPR60F09 neurons, that were responsive to both light and temperature change, including cooling and warming. ACLPR60F09 neurons could be excited by pdf-LaN neurons in the visual pathway. On the downstream side, they could inhibit the CLPNR82B09 neurons that command light induced reorientation behavior. Compared with at warm temperature, ACLPR60F09 neurons’ response to light was decreased at cool temperature so that the inhibition on CLPNR82B09 neurons was relieved and the light induced avoidance was enhanced. Our result proposed a neural mechanism underlying cross-modal modulation of animal innate avoidance behavior.

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Faculty Opinions recommendation of Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119289.575465 ◽

2008 ◽

Author(s):

Valina Dawson

Keyword(s):

Mouse Brain ◽

Brain Neurons ◽

Pale Bodies

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High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera

EJNMMI Physics ◽

10.1186/s40658-020-00334-7 ◽

2020 ◽

Vol 7 (1) ◽

Author(s):

Manon Bordonne ◽

Mohammad B. Chawki ◽

Pierre-Yves Marie ◽

Timothée Zaragori ◽

Véronique Roch ◽

...

Keyword(s):

Image Quality ◽

High Speed ◽

Brain Perfusion ◽

Fold Increase ◽

Brain Structures ◽

Czt Camera ◽

Recording Time ◽

Brain Perfusion Spect ◽

Central Brain ◽

Perfusion Spect

Abstract Objective The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera. Methods The 360° CZT camera utilizing a brain configuration, with 12 detectors surrounding the head, was compared to a 2-head Anger camera for count sensitivity and image quality on 30-min SPECT recordings from a brain phantom and from 99mTc-HMPAO brain perfusion in 2 groups of 21 patients investigated with the CZT and Anger cameras, respectively. Image reconstruction was adjusted according to image contrast for each camera. Results The CZT camera provided more than 2-fold increase in count sensitivity, as compared with the Anger camera, as well as (1) lower sharpness indexes, giving evidence of higher spatial resolution, for both peripheral/central brain structures, with respective median values of 5.2%/3.7% versus 2.4%/1.9% for CZT and Anger camera respectively in patients (p < 0.01), and 8.0%/6.9% versus 6.2%/3.7% on phantom; and (2) higher gray/white matter contrast on peripheral/central structures, with respective ratio median values of 1.56/1.35 versus 1.11/1.20 for CZT and Anger camera respectively in patients (p < 0.05), and 2.57/2.17 versus 1.40/1.12 on phantom; and (3) no change in noise level. Image quality, scored visually by experienced physicians, was also significantly higher on CZT than on the Anger camera (+ 80%, p < 0.01), and all these results were unchanged on the CZT images obtained with only a 15 min recording time. Conclusion The 360° CZT camera provides brain perfusion images of much higher quality than a conventional Anger camera, even with high-speed recordings, thus demonstrating the potential for repositioning brain perfusion SPECT to the forefront of brain imaging.

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The correlation between Na+ channel subunits and scorpion toxin-binding sites. A study in rat brain synaptosomes and in brain neurons developing in vitro.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)57338-0 ◽

1988 ◽

Vol 263 (3) ◽

pp. 1542-1548

Author(s):

E Jover ◽

A Massacrier ◽

P Cau ◽

M F Martin ◽

F Couraud

Keyword(s):

Rat Brain ◽

Binding Sites ◽

Scorpion Toxin ◽

Na Channel ◽

Brain Neurons ◽

Rat Brain Synaptosomes ◽

Toxin Binding ◽

Brain Synaptosomes

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Molecular Characterization of Prothoracicotropic Hormone (PTTH) from the Giant SilkmothAntheraea pernyi:Developmental Appearance of PTTH-Expressing Cells and Relationship to Circadian Clock Cells in Central Brain

Developmental Biology ◽

10.1006/dbio.1996.0228 ◽

1996 ◽

Vol 178 (2) ◽

pp. 418-429 ◽

Cited By ~ 80

Author(s):

Ivo Sauman ◽

Steven M. Reppert

Keyword(s):

Circadian Clock ◽

Molecular Characterization ◽

Prothoracicotropic Hormone ◽

Central Brain

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The fruitless gene affects female receptivity and species isolation

Proceedings of The Royal Society B Biological Sciences ◽

10.1098/rspb.2019.2765 ◽

2020 ◽

Vol 287 (1923) ◽

pp. 20192765 ◽

Cited By ~ 1

Author(s):

Tabashir Chowdhury ◽

Ryan M. Calhoun ◽

Katrina Bruch ◽

Amanda J. Moehring

Keyword(s):

Mate Choice ◽

Critical Role ◽

Sensory Modality ◽

Female Mate Choice ◽

Neural Basis ◽

Female Receptivity ◽

Female Mate ◽

Multiple Transcripts ◽

Female Behaviour ◽

Substrate Vibrations

Female mate rejection acts as a major selective force within species, and can serve as a reproductive barrier between species. In spite of its critical role in fitness and reproduction, surprisingly little is known about the genetic or neural basis of variation in female mate choice. Here, we identify fruitless as a gene affecting female receptivity within Drosophila melanogaster , as well as female Drosophila simulans rejection of male D. melanogaster . Of the multiple transcripts this gene produces, by far the most widely studied is the sex-specifically spliced transcript involved in the sex determination pathway. However, we find that female rejection behaviour is affected by a non-sex-specifically spliced fruitless transcript. This is the first implication of fruitless in female behaviour, and the first behavioural role identified for a fruitless non-sex-specifically spliced transcript. We found that this locus does not influence preferences via a single sensory modality, examining courtship song, antennal pheromone perception, or perception of substrate vibrations, and we conclude that fruitless influences mate choice via the integration of multiple signals or through another sensory modality.

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