Juvenile social defeat stress exposure persistently impairs social behaviors and neurogenesis

2018 ◽  
Vol 133 ◽  
pp. 23-37 ◽  
Author(s):  
Akihiro Mouri ◽  
Mayu Ukai ◽  
Mizuki Uchida ◽  
Sho Hasegawa ◽  
Masayuki Taniguchi ◽  
...  
Keyword(s):  
Social Behaviors ◽  
Social Defeat ◽  
Stress Exposure ◽  
Social Defeat Stress

scholarly journals Stress-induced sleep-like inactivity modulates stress susceptibility in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Midori Nagai ◽  
Hirotaka Nagai ◽  
Chisato Numa ◽  
Tomoyuki Furuyashiki
Keyword(s):  
Sleep Deprivation ◽  
Social Stress ◽  
Social Interest ◽  
Social Behaviors ◽  
Social Defeat ◽  
Brain Regions ◽  
Social Characteristics ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Positive Valence

AbstractSevere environmental and social stress induces dysregulation of sleep along with mood and cognitive disturbances. However, the role and mechanism of this sleep dysregulation remain elusive. Here we evaluated sleep-like inactivity measured by voluntary movements and its relationship to social behaviors in mice without or with social defeat stress as well as the stressed mice with subsequent sleep deprivation. Social defeat stress immediately induced sleep-like inactivity with decreased body temperature. In the social interaction test, the control mice showed high social interest and its correlation with social sniffing intensity, the latter of which indicates positive valence of social sniffing. After the stress, these social characteristics were maintained in stress-resilient mice, but disrupted in stress-susceptible mice, leading to social avoidance. Sleep deprivation after the stress decreased social sniffing intensity along with reduced social interest, but enhanced the exploratory activity with the positive valence of social sniffing. We also found by c-Fos immunohistochemistry that the stress activated sleep-related brain regions, the dorsomedial hypothalamus and ventrolateral periaqueductal gray. Collectively, these findings show that stress activates sleep-related brain regions and induces sleep-like inactivity, contributing to multiple roles of stress-induced sleep for social behaviors.

scholarly journals Chronic Social Defeat Stress Shifts Peripheral Circadian Clocks in Male Mice in a Tissue-Specific and Time-of-Day Dependent Fashion

2022 ◽  
pp. 074873042110653
Author(s):  
Xiangpan Kong ◽  
Simone M. Ota ◽  
Deborah Suchecki ◽  
Andy Lan ◽  
Anouk I. Peereboom ◽  
...  
Keyword(s):  
Acute Stress ◽  
Social Defeat ◽  
Time Of Day ◽  
Dark Phase ◽  
Stress Exposure ◽  
Social Defeat Stress ◽  
Peripheral Tissues ◽  
Tissue Specific ◽  
Chronic Social Defeat Stress ◽  
Peripheral Clocks

Uncontrollable stress is linked to the development of many diseases, some of which are associated with disrupted daily rhythms in physiology and behavior. While available data indicate that the master circadian pacemaker in the suprachiasmatic nucleus (SCN) is unaffected by stress, accumulating evidence suggest that circadian oscillators in peripheral tissues and organs can be shifted by a variety of stressors and stress hormones. In the present study, we examined effects of acute and chronic social defeat stress in mice and addressed the question of whether effects of uncontrollable stress on peripheral clocks are tissue specific and depend on time of day of stress exposure. We used mice that carry a luciferase reporter gene fused to the circadian clock gene Period2 (PER2::LUC) to examine daily rhythms of PER2 expression in various peripheral tissues. Mice were exposed to social defeat stress in the early (ZT13-14) or late (ZT21-22) dark phase, either once (acute stress) or repeatedly on 10 consecutive days (chronic stress). One hour after the last stressor, tissue samples from liver, lung, kidney, and white adipose tissue (WAT) were collected. Social defeat stress caused a phase delay of several hours in the rhythm of PER2 expression in lung and kidney, but this delay was stronger after chronic than after acute stress. Moreover, shifts only occurred after stress in the late dark phase, not in the early dark phase. PER2 rhythms in liver and WAT were not significantly shifted by social defeat, suggesting a different response of various peripheral clocks to stress. This study indicates that uncontrollable social defeat stress is capable of shifting peripheral clocks in a time of day dependent and tissue specific manner. These shifts in peripheral clocks were smaller or absent after a single stress exposure and may therefore be the consequence of a cumulative chronic stress effect.

scholarly journals Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice

2022 ◽  
Vol 19 (1) ◽  
Author(s):  
Fu Li ◽  
Haitao Xiang ◽  
Yue Gu ◽  
Ting Ye ◽  
Xu Lu ◽  
...  
Keyword(s):  
Lipid A ◽  
Social Defeat ◽  
Innate Immune ◽  
Stress Exposure ◽  
Preventive Effect ◽  
Social Defeat Stress ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid ◽  
Chronic Social Defeat Stress ◽  
The Brain

Abstract Background Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in animals remains unclear. We addressed this issue using monophosphoryl lipid A (MPL), a derivative of lipopolysaccharide (LPS) that lacks undesirable properties of LPS but still keeps immune-enhancing activities. Methods The experimental mice were pre-injected intraperitoneally with MPL before stress exposure. Depression was induced through chronic social defeat stress (CSDS). Behavioral tests were conducted to identify anxiety-like behaviors. Real-time polymerase chain reaction (PCR) and biochemical assays were employed to examine the gene and protein expression levels of pro-inflammatory markers. Results A single MPL injection at the dose of 400 and 800 μg/kg 1 day before stress exposure prevented CSDS-induced anxiety-like behaviors, and a single MPL injection (400 μg/kg) five but not 10 days before stress exposure produced similar effect. The preventive effect of MPL on anxiety-like behaviors was also observed in CSDS mice who received a second MPL injection 10 days after the first MPL injection or a 4 × MPL injection 10 days before stress exposure. MPL pre-injection also prevented the production of pro-inflammatory cytokines in the hippocampus and medial prefrontal cortex in CSDS mice, and inhibiting the central immune response by minocycline pretreatment abrogated the preventive effect of MPL on CSDS-induced anxiety-like behaviors and pro-inflammatory cytokine productions in the brain. Conclusions Pre-stimulation of the innate immune system by MPL can prevent chronic stress-induced anxiety-like behaviors and neuroinflammatory responses in the brain in mice.

Altered myeloid and lymphoid immune cell responses following repeated social defeat stress

2015 ◽  
Vol 48 (06) ◽  
Author(s):  
O Ambree ◽  
C Ruland ◽  
P Zwanzger ◽  
V Arolt ◽  
J Alferink
Keyword(s):  
Immune Cell ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Cell Responses
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