Impaired semantic knowledge underlies the reduced verbal short-term storage capacity in Alzheimer's disease

2009 ◽  
Vol 47 (14) ◽  
pp. 3067-3073 ◽  
Author(s):  
Frédéric Peters ◽  
Steve Majerus ◽  
Julie De Baerdemaeker ◽  
Eric Salmon ◽  
Fabienne Collette
2007 ◽  
Vol 29 (4) ◽  
pp. 405-417 ◽  
Author(s):  
Frédéric Peters ◽  
Steve Majerus ◽  
Laurence Olivier ◽  
Martial van der Linden ◽  
Eric Salmon ◽  
...  

2012 ◽  
Vol 140 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Thomas Alrik Sørensen ◽  
Søren Kyllingsbæk

2013 ◽  
Vol 24 (8) ◽  
pp. 1967-1978 ◽  
Author(s):  
I. Wiegand ◽  
T. Tollner ◽  
T. Habekost ◽  
M. Dyrholm ◽  
H. J. Muller ◽  
...  

2019 ◽  
Author(s):  
Zeljana Babic ◽  
Mark Schurgin ◽  
Timothy F. Brady

Working memory is a core cognitive system that actively maintains information in an accessible state to support a variety of everyday tasks. Crucially, working memory performance has frequently been shown to strongly correlate with fluid intelligence. Traditionally when these correlations have been observed, the working memory tasks involved required a high degree of manipulation and executive function, as opposed to solely utilizing short-term storage capacity. However, recent work has claimed that simple storage capacity is also correlated with fluid intelligence, and that this is driven by a particularly special and dissociable component of capacity, the ‘number of items represented’ (rather than the precision of those representations). These results have been used to argue that investigating the underlying mechanisms of capacity limitations may be critical to understanding aspects of fluid intelligence. Here we demonstrate that such correlations do not arise solely or primarily from simple storage capacity (nor a single dissociable component of capacity), but are driven by the availability of strategic encoding of different kinds of visual representations. Specifically, a working memory task that decreased the utility of storing and making use of spatial ensemble information, while holding constant the number of items to be remembered and the exact changes participants needed to detect, significantly reduced the correlation between working memory performance and fluid intelligence. Thus, despite being probed on the same items, with the same foils, at the same set size, only working memory displays that allowed for the strategic use of both item and ensemble representations correlated with fluid intelligence. These results provide evidence against the hypothesis that simple storage alone is related to fluid intelligence. They also demonstrate that participants make use of more complex and structured representations rather than solely individual item representation, and that strategic utilization of these representations is what correlates strongly with fluid intelligence.


Author(s):  
Keng Yoon Yeong ◽  
Christine Law

Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review.


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