Individual differences in trait anxiety are associated with white matter tract integrity in the left temporal lobe in healthy males but not females

Abstract Connectome maps region-to-region connectivities but does not inform which white matter pathways form the connections. Here we constructed the first population-based tract-to-region connectome to fill this information gap. The constructed connectome quantifies the population probability of a white matter tract innervating a cortical region. The results show that ~85% of the tract-to-region connectome entries are consistent across individuals, whereas the remaining (~15%) have substantial individual differences requiring individualized mapping. Further hierarchical clustering on cortical regions revealed their parcellations into dorsal, ventral, and limbic networks based on the tract-to-region connective patterns. The clustering results on white matter bundles revealed the connectome-based categorization of fiber bundle systems in the association pathways. This new tract-to-region connectome provides insights into the connective topology between cortical regions and white matter bundles. The derived hierarchical relation further offers a connectome-based categorization of gray matter and white matter structures.

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Investigating temporal lobe contribution to confrontation naming using MRI quantitative volumetrics

Journal of the International Neuropsychological Society ◽

10.1017/s135561770505054x ◽

2005 ◽

Vol 11 (4) ◽

pp. 358-366 ◽

Cited By ~ 34

Author(s):

MICHAEL SEIDENBERG ◽

ELIZABETH GEARY ◽

BRUCE HERMANN

Keyword(s):

White Matter ◽

Temporal Lobe ◽

Relative Role ◽

White Matter Volume ◽

Left Temporal Lobe ◽

Matter Volume ◽

Confrontation Naming ◽

Left Hippocampus ◽

Hippocampus Volume ◽

Naming Performance

Confrontation naming ability entails the operation of distinct cognitive operations and the integrity of a distributed neural network. Previous research has indicated a critical role for the left temporal lobe region in naming ability, but there is less agreement about the relative role of distinct temporal lobe regions. In the current paper, we used quantitative MR volumetrics to investigate the relative contribution of the hippocampus and extrahippocampal temporal lobe (segmented gray and white matter) volumes to confrontation naming performance in 53 patients with temporal lobe epilepsy. Findings showed (1) a stronger relationship for left temporal lobe volume than right temporal lobe volume in predicting naming performance; (2) both left temporal lobe white matter volume and left hippocampus volume contributed a significant amount of unique variance to spontaneous naming performance; and (3) left temporal lobe white matter volume but not left hippocampus volume predicted recognition naming performance. (JINS, 2005,11, 358–366.)

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Disrupted topological properties of brain white matter networks in left temporal lobe epilepsy: A diffusion tensor imaging study

Neuroscience ◽

10.1016/j.neuroscience.2014.08.040 ◽

2014 ◽

Vol 279 ◽

pp. 155-167 ◽

Cited By ~ 11

Author(s):

Y. Xu ◽

S. Qiu ◽

J. Wang ◽

Z. Liu ◽

R. Zhang ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Diffusion Tensor ◽

Imaging Study ◽

Topological Properties ◽

Left Temporal Lobe ◽

Brain White Matter ◽

Diffusion Tensor Imaging Study

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Neuronal heterotopia with capillary penetration of neurons and cortical dysplasia in a patient with complex partial seizures

Journal of Neurosurgery ◽

10.3171/jns.1993.78.4.0654 ◽

1993 ◽

Vol 78 (4) ◽

pp. 654-657 ◽

Cited By ~ 11

Author(s):

Venita Jay ◽

Laurence E. Becker ◽

Hiroshi Otsubo ◽

Paul Hwang ◽

Harold J. Hoffman ◽

...

Keyword(s):

White Matter ◽

Temporal Lobe ◽

Cortical Dysplasia ◽

Neuronal Morphology ◽

Partial Seizures ◽

Left Temporal Lobe ◽

Complex Partial Seizures ◽

Epileptiform Discharges ◽

Vascular Elements ◽

Developmental Disturbance

✓ Unusual pathological findings were encountered in a temporal lobectomy specimen from a 9-year-old boy with intractable complex partial seizures. Magnetic resonance imaging revealed an enlarged left temporal lobe, with diffuse high signal intensity over the cortex and poor gray-white differentiation on T2-weighted imaging; single-photon emission computerized tomography showed decreased blood flow. Active epileptiform discharges were identified in the left temporal lobe with focal slow waves and generalized epileptiform paroxysms. Pathologically, the cortex revealed changes of focal cortical dysplasia with extensive disorganization of neuronal morphology, layering, and orientation as well as focal polymicrogyria. The cortical-white matter junction was indistinct with extensive neuronal heterotopias in the white matter. Large pale balloon cells akin to those seen in tuberous sclerosis were found scattered within the cortex and white matter. The most striking finding was that of a heterotopic nodule in the white matter, which revealed abnormal neurons with penetration of cell bodies by capillaries. Ultrastructurally, there were no degenerative changes in these neurons, and this unusual phenomenon is attributed to a developmental disturbance affecting neuronal, glial, and vascular elements.

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