Response properties of local field potentials and multiunit activity in the mouse visual cortex

Correlations and inferred causal interactions among local field potentials (LFPs) simultaneously recorded in distinct visual brain areas can provide insight into how visual and cognitive signals are communicated between neuronal populations. Based on the known anatomical connectivity of hierarchically organized visual cortical areas and electrophysiological measurements of LFP interactions, a framework for interareal frequency-specific communication has emerged. Our goals were to test the predictions of this framework in the context of the early visual pathways and to understand how attention modulates communication between the visual thalamus and primary visual cortex. We recorded LFPs simultaneously in retinotopically aligned regions of the visual thalamus and primary visual cortex in alert and behaving macaque monkeys trained on a contrast-change detection task requiring covert shifts in visual spatial attention. Coherence and Granger-causal interactions among early visual circuits varied dynamically over different trial periods. Attention significantly enhanced alpha-, beta-, and gamma-frequency interactions, often in a manner consistent with the known anatomy of early visual circuits. However, attentional modulation of communication among early visual circuits was not consistent with a simple static framework in which distinct frequency bands convey directed inputs. Instead, neuronal network interactions in early visual circuits were flexible and dynamic, perhaps reflecting task-related shifts in attention. NEW & NOTEWORTHY Attention alters the way we perceive the visual world. For example, attention can modulate how visual information is communicated between the thalamus and cortex. We recorded local field potentials simultaneously in the visual thalamus and cortex to quantify the impact of attention on visual information communication. We found that attentional modulation of visual information communication was not static, but dynamic over the time course of trials.

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Spectral Analysis of Local Field Potentials from Rat Primary Visual Cortex (V1)

Frontiers in Computational Neuroscience ◽

10.3389/conf.fncom.2012.55.00087 ◽

2012 ◽

Vol 6 ◽

Author(s):

Aertsen Ad

Keyword(s):

Spectral Analysis ◽

Visual Cortex ◽

Primary Visual Cortex ◽

Local Field ◽

Local Field Potentials ◽

Field Potentials

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Low-Frequency Local Field Potentials and Spikes in Primary Visual Cortex Convey Independent Visual Information

Journal of Neuroscience ◽

10.1523/jneurosci.0009-08.2008 ◽

2008 ◽

Vol 28 (22) ◽

pp. 5696-5709 ◽

Cited By ~ 257

Author(s):

A. Belitski ◽

A. Gretton ◽

C. Magri ◽

Y. Murayama ◽

M. A. Montemurro ◽

...

Keyword(s):

Visual Cortex ◽

Primary Visual Cortex ◽

Local Field ◽

Visual Information ◽

Local Field Potentials ◽

Low Frequency ◽

Field Potentials

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Discriminating visual stimuli from local field potentials recorded with a multi-electrode array in the monkey’s visual cortex

2008 IEEE Workshop on Machine Learning for Signal Processing ◽

10.1109/mlsp.2008.4685472 ◽

2008 ◽

Cited By ~ 1

Author(s):

Nikolay V. Manyakov ◽

Marc M. Van Hulle

Keyword(s):

Visual Cortex ◽

Local Field ◽

Visual Stimuli ◽

Local Field Potentials ◽

Electrode Array ◽

Field Potentials ◽

Multi Electrode Array

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Isoflurane and ketamine differentially influence spontaneous and evoked laminar electrophysiology in mouse V1

Journal of Neurophysiology ◽

10.1152/jn.00299.2018 ◽

2018 ◽

Vol 120 (5) ◽

pp. 2232-2245 ◽

Cited By ~ 23

Author(s):

Nicholas J. Michelson ◽

Takashi D. Y. Kozai

Keyword(s):

Local Field ◽

Visual Information ◽

Molecular Mechanisms ◽

Local Field Potentials ◽

Field Potential ◽

Field Potentials ◽

Resting State Functional Connectivity ◽

Multiunit Activity ◽

Ketamine Anesthesia ◽

Deep Layers

General anesthesia is ubiquitous in research and medicine, yet although the molecular mechanisms of anesthetics are well characterized, their ultimate influence on cortical electrophysiology remains unclear. Moreover, the influence that different anesthetics have on sensory cortexes at neuronal and ensemble scales is mostly unknown and represents an important gap in knowledge that has widespread relevance for neural sciences. To address this knowledge gap, this work explored the effects of isoflurane and ketamine/xylazine, two widely used anesthetic paradigms, on electrophysiological behavior in mouse primary visual cortex. First, multiunit activity and local field potentials were examined to understand how each anesthetic influences spontaneous activity. Then, the interlaminar relationships between populations of neurons at different cortical depths were studied to assess whether anesthetics influenced resting-state functional connectivity. Lastly, the spatiotemporal dynamics of visually evoked multiunit and local field potentials were examined to determine how each anesthetic alters communication of visual information. We found that isoflurane enhanced the rhythmicity of spontaneous ensemble activity at 10–40 Hz, which coincided with large increases in coherence between layer IV with superficial and deep layers. Ketamine preferentially increased local field potential power from 2 to 4 Hz, and the largest increases in coherence were observed between superficial and deep layers. Visually evoked responses across layers were diminished under isoflurane, and enhanced under ketamine anesthesia. These findings demonstrate that isoflurane and ketamine anesthesia differentially impact sensory processing in V1. NEW & NOTEWORTHY We directly compared electrophysiological responses in awake and anesthetized (isoflurane or ketamine) mice. We also proposed a method for quantifying and visualizing highly variable, evoked multiunit activity. Lastly, we observed distinct oscillatory responses to stimulus onset and offset in awake and isoflurane-anesthetized mice.

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Decoding 3D reach and grasp from hybrid signals in motor and premotor cortices: spikes, multiunit activity, and local field potentials

Journal of Neurophysiology ◽

10.1152/jn.00781.2011 ◽

2012 ◽

Vol 107 (5) ◽

pp. 1337-1355 ◽

Cited By ~ 114

Author(s):

Arjun K. Bansal ◽

Wilson Truccolo ◽

Carlos E. Vargas-Irwin ◽

John P. Donoghue

Keyword(s):

Local Field ◽

Local Field Potentials ◽

Multielectrode Arrays ◽

Field Potentials ◽

Frequency Bands ◽

Reach And Grasp ◽

Multiunit Activity ◽

Relative Value ◽

Movement Parameters ◽

First Time

Neural activity in motor cortex during reach and grasp movements shows modulations in a broad range of signals from single-neuron spiking activity (SA) to various frequency bands in broadband local field potentials (LFPs). In particular, spatiotemporal patterns in multiband LFPs are thought to reflect dendritic integration of local and interareal synaptic inputs, attentional and preparatory processes, and multiunit activity (MUA) related to movement representation in the local motor area. Nevertheless, the relationship between multiband LFPs and SA, and their relationship to movement parameters and their relative value as brain-computer interface (BCI) control signals, remain poorly understood. Also, although this broad range of signals may provide complementary information channels in primary (MI) and ventral premotor (PMv) areas, areal differences in information have not been systematically examined. Here, for the first time, the amount of information in SA and multiband LFPs was compared for MI and PMv by recording from dual 96-multielectrode arrays while monkeys made naturalistic reach and grasp actions. Information was assessed as decoding accuracy for 3D arm end point and grip aperture kinematics based on SA or LFPs in MI and PMv, or combinations of signal types across areas. In contrast with previous studies with ≤16 simultaneous electrodes, here ensembles of >16 units (on average) carried more information than multiband, multichannel LFPs. Furthermore, reach and grasp information added by various LFP frequency bands was not independent from that in SA ensembles but rather typically less than and primarily contained within the latter. Notably, MI and PMv did not show a particular bias toward reach or grasp for this task or for a broad range of signal types. For BCIs, our results indicate that neuronal ensemble spiking is the preferred signal for decoding, while LFPs and combined signals from PMv and MI can add robustness to BCI control.

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Muscimol and baclofen differentially suppress retinotopic and nonretinotopic responses in visual cortex

Visual Neuroscience ◽

10.1017/s0952523805226135 ◽

2005 ◽

Vol 22 (6) ◽

pp. 839-858 ◽

Cited By ~ 7

Author(s):

TAKUJI KASAMATSU ◽

KEIKO MIZOBE ◽

ERICH E. SUTTER

Keyword(s):

Visual Cortex ◽

Long Range ◽

Local Field ◽

Receptor Agonist ◽

Single Cells ◽

Receptive Fields ◽

Local Field Potentials ◽

Field Potentials ◽

Basal Dendrites ◽

Stimulation Of

This study relates to local field potentials and single-unit responses in cat visual cortex elicited by contrast reversal of bar gratings that were presented in single, double, or multiple discrete patch (es) of the visual field. Concurrent stimulation of many patches by means of the pseudorandom, binary m-sequence technique revealed interactions between their respective responses. An analysis identified two distinct components of local field potentials: a fast local component (FLC) and a slow distributed component (SDC). The FLC is thought to be a primarily postsynaptic response, as judged by its relatively short latency. It is directly generated by thalamocortical volleys following retinotopic stimulation of receptive fields of a small cluster of single cells, combined with responses to recurrent excitation and inhibition derived from the cells under study and immediately neighboring cells. In contrast, the SDC is thought to be an aggregate of dendritic potentials related to the long-range lateral connections (i.e. long-range coupling). We compared the suppressive effects of a GABAA-receptor agonist, muscimol, on the FLC and SDC with those of a GABAB-receptor agonist, baclofen, and found that muscimol more strongly suppressed the FLC than the SDC, and that the reverse was the case for baclofen. The differential suppression of the FLC and SDC found in the present study is consistent with the notion that intracortical electrical signals related to the FLC terminate on the somata and proximal/basal dendrites, while those related to the SDC terminate on distal dendrites.

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