Social pain and physical pain have historically been conceptualized as distinct phenomena. Recent research, however, has noted several similarities between the two. The present chapter establishes the physiological basis of social pain. Further, the chapter explores the relational precedents and correlates of social pain. By synthesizing research that explores definitional elements of social pain, the reviewed literature explores the social basis of hurt. The chapter also reviews the extant research that posits similarities in the neural processing of social and physical pain. These similarities are further explained by examining findings that have emphasized parallels between cognitive, behavioral, and physiological responses to both social and physical pain. Shortcomings in the current research are reviewed, and several future directions are offered for researchers interested in the physiology of social pain.