Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles

2019 ◽  
Vol 166 ◽  
pp. 107082 ◽  
Author(s):  
Tahereh Dara ◽  
Alireza Vatanara ◽  
Mohammad Sharifzadeh ◽  
Samira Khani ◽  
Molood Alsadat Vakilinezhad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Solid Lipid Nanoparticles ◽  
Memory Deficits ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Model Of Alzheimer’S Disease

scholarly journals Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer’s disease animal model by reducing Tau hyperphosphorylation

2018 ◽  
Vol 26 (2) ◽  
pp. 165-177 ◽  
Author(s):  
Molood Alsadat Vakilinezhad ◽  
Azadeh Amini ◽  
Hamid Akbari Javar ◽  
Batool Faegheh Baha’addini Beigi Zarandi ◽  
Hashem Montaseri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Tau Hyperphosphorylation ◽  
Solid Lipid

A comparative in vivo evaluation of anti-alzheimer activity of bacopa extract and its solid lipid nanoparticles

2020 ◽  
Vol 16 ◽  
Author(s):  
Rajesh Kumar ◽  
Rajeev Garg ◽  
Navneet Khurana
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Extended Period ◽  
Lipid Nanoparticles ◽  
Nootropic Activity ◽  
Active Constituent ◽  
In Vivo Evaluation ◽  
Solid Lipid

Purpose: Bacopa monnieri (Brahmi; family Scrophulariaceae) is a well-known plant known for its nootropic activity. Delivery of Bacosides (active constituent) is limited at the site of action owing to the existence of blood-brain barrier (BBB). In order to take the bacoside rich extract (BRE) across BBB, formulated solid lipid nanoparticles (SLNs) were used. Objective: The objective of this work was to evaluate the pharmacokinetic and pharmacodynamic behavior (in vivo potential) of the prepared SLNs containing BRE in comparison to BRE alone for the treatment of Alzheimer’s disease. Methods: Swiss albino male mice (25-30 gm) were used for the study. The pharmacokinetic as well as pharmacodynamic evaluation of formulated SLNs was performed in comparison to BRE in scopolamine-induced amnesia model. Results: BRE-loaded SLNs were found to be significantly more effective than BRE in alleviating the neurodegeneration. The pharmacokinetic study revealed the improved bioavailability of prepared SLNs with the potential of sustaining the drug release in mice for an extended period of time. Conclusion: The results demonstrated that the SLNs may be considered a potential delivery system for taking BRE across BBB to treat Alzheimer’s disease.

Newly Synthesized Acetylcholinesterase Inhibitors for Alleviating Alzheimer’s Disease using Solid Lipid Nanoparticles

2014 ◽  
Vol 9 (2) ◽  
pp. 111-123 ◽  
Author(s):  
Rohit Makkar ◽  
Paramveer Singh ◽  
Chhanda C. Danta ◽  
Vandita Kakkar ◽  
Indu P. Kaur ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Acetylcholinesterase Inhibitors ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer’s disease: an exploration of underlying mechanisms

2017 ◽  
Vol 234 (12) ◽  
pp. 1841-1852 ◽  
Author(s):  
Zahra Kiasalari ◽  
Rana Heydarifard ◽  
Mohsen Khalili ◽  
Siamak Afshin-Majd ◽  
Tourandokht Baluchnejadmojarad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning And Memory ◽  
Rat Model ◽  
Ellagic Acid ◽  
Memory Deficits ◽  
Model Of Alzheimer’S Disease ◽  
Learning And Memory Deficits ◽  
Underlying Mechanisms
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