Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease

Neuropeptides ◽  
2016 ◽  
Vol 58 ◽  
pp. 111-125 ◽  
Author(s):  
Aishwarya Vedagiri ◽  
Sumathi Thangarajan
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Hippocampal Region ◽  
Solid Lipid

Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles

2019 ◽  
Vol 166 ◽  
pp. 107082 ◽  
Author(s):  
Tahereh Dara ◽  
Alireza Vatanara ◽  
Mohammad Sharifzadeh ◽  
Samira Khani ◽  
Molood Alsadat Vakilinezhad ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Solid Lipid Nanoparticles ◽  
Memory Deficits ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Model Of Alzheimer’S Disease

scholarly journals Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer’s disease animal model by reducing Tau hyperphosphorylation

2018 ◽  
Vol 26 (2) ◽  
pp. 165-177 ◽  
Author(s):  
Molood Alsadat Vakilinezhad ◽  
Azadeh Amini ◽  
Hamid Akbari Javar ◽  
Batool Faegheh Baha’addini Beigi Zarandi ◽  
Hashem Montaseri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Tau Hyperphosphorylation ◽  
Solid Lipid

A comparative in vivo evaluation of anti-alzheimer activity of bacopa extract and its solid lipid nanoparticles

2020 ◽  
Vol 16 ◽  
Author(s):  
Rajesh Kumar ◽  
Rajeev Garg ◽  
Navneet Khurana
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Extended Period ◽  
Lipid Nanoparticles ◽  
Nootropic Activity ◽  
Active Constituent ◽  
In Vivo Evaluation ◽  
Solid Lipid

Purpose: Bacopa monnieri (Brahmi; family Scrophulariaceae) is a well-known plant known for its nootropic activity. Delivery of Bacosides (active constituent) is limited at the site of action owing to the existence of blood-brain barrier (BBB). In order to take the bacoside rich extract (BRE) across BBB, formulated solid lipid nanoparticles (SLNs) were used. Objective: The objective of this work was to evaluate the pharmacokinetic and pharmacodynamic behavior (in vivo potential) of the prepared SLNs containing BRE in comparison to BRE alone for the treatment of Alzheimer’s disease. Methods: Swiss albino male mice (25-30 gm) were used for the study. The pharmacokinetic as well as pharmacodynamic evaluation of formulated SLNs was performed in comparison to BRE in scopolamine-induced amnesia model. Results: BRE-loaded SLNs were found to be significantly more effective than BRE in alleviating the neurodegeneration. The pharmacokinetic study revealed the improved bioavailability of prepared SLNs with the potential of sustaining the drug release in mice for an extended period of time. Conclusion: The results demonstrated that the SLNs may be considered a potential delivery system for taking BRE across BBB to treat Alzheimer’s disease.

Newly Synthesized Acetylcholinesterase Inhibitors for Alleviating Alzheimer’s Disease using Solid Lipid Nanoparticles

2014 ◽  
Vol 9 (2) ◽  
pp. 111-123 ◽  
Author(s):  
Rohit Makkar ◽  
Paramveer Singh ◽  
Chhanda C. Danta ◽  
Vandita Kakkar ◽  
Indu P. Kaur ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Acetylcholinesterase Inhibitors ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease

Molecules ◽  
2017 ◽  
Vol 22 (2) ◽  
pp. 277 ◽  
Author(s):  
Joana Loureiro ◽  
Stephanie Andrade ◽  
Ana Duarte ◽  
Ana Neves ◽  
Joana Queiroz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Grape Extract ◽  
Solid Lipid

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 10001-10010 ◽  
Author(s):  
Prakash Chandra Bhatt ◽  
Pranay Srivastava ◽  
Preeti Pandey ◽  
Washim Khan ◽  
Bibhu Prasad Panda
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Pc12 Cells ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Biological Studies ◽  
Conventional Dosage

Astaxanthin nanoformulation was found appropriate in all measures with strong antioxidant activity against H2O2induced oxidative stress in PC12 cells. Biodistribution and brain delivery was also found to be superior to conventional dosage form.

Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles

2009 ◽  
Vol 43 (11) ◽  
pp. 1133-1145 ◽  
Author(s):  
Pasquale Picone ◽  
Maria L. Bondi ◽  
Pasquale Picone ◽  
Maria L. Bondi ◽  
Giovanna Montana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Ferulic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid
Sign in / Sign up

Export Citation Format

Share Document