Using animal models to study effects of prenatal infection on brain development and behavior relevant to psychiatric disorders

2013 ◽  
Vol 37 ◽  
pp. 76
Author(s):  
Patricia Boksa ◽  
M. Burt ◽  
Y.C. Tse ◽  
T.P. Wong ◽  
L. Harvey
Author(s):  
Peter H. Rudebeck ◽  
Alicia Izquierdo

AbstractEfficient foraging is essential to survival and depends on frontal cortex in mammals. Because of its role in psychiatric disorders, frontal cortex and its contributions to reward procurement have been studied extensively in both rodents and non-human primates. How frontal cortex of these animal models compares is a source of intense debate. Here we argue that translating findings from rodents to non-human primates requires an appreciation of both the niche in which each animal forages as well as the similarities in frontal cortex anatomy and function. Consequently, we highlight similarities and differences in behavior and anatomy, before focusing on points of convergence in how parts of frontal cortex contribute to distinct aspects of foraging in rats and macaques, more specifically. In doing so, our aim is to emphasize where translation of frontal cortex function between species is clearer, where there is divergence, and where future work should focus. We finish by highlighting aspects of foraging for which have received less attention but we believe are critical to uncovering how frontal cortex promotes survival in each species.


2009 ◽  
pp. 77-104
Author(s):  
Jana Velíšková ◽  
Annamaria Vezzani ◽  
Astrid Nehlig

2010 ◽  
Vol 138 (3-4) ◽  
pp. 136-142 ◽  
Author(s):  
Svetlana Jovanovic ◽  
Ivanka Gajic ◽  
Jelena Mandic ◽  
Bojan Mandic

Introduction. People with psychiatric disorders are at high risk of oral diseases due to the impact of their primary psychiatric condition and the side-effects of antipsychotic medications. Objective. The aim of this study was to identify habits, attitudes and behavior towards oral health of hospitalized psychiatric patients with psychotic disorders, including mood disorders with psychotic characteristics, as well as to identify factors that could influence those habits, attitudes and behavior. Methods. The experimental group consisted of 186 hospitalized patients with psychiatric disorders (87 males and 99 females), aged from 18 to 59 years (mean age 46.0?8.0 years). The control group consisted of 186 healthy persons matched for age and gender. Data were obtained by using specially designed questionnaires with questions about the subjects' social, economic and demographic characteristics, as well as their habits, attitudes and behaviour concerning their oral health, in a form of a standardized interview. Other medical data were collected from medical documentation of disease history. Statistical analysis was performed by Student's t-test, Chi-square test, ANOVA, Logistic Regression and simultaneous multiple regression. Results. Psychiatric patients have worse habits, attitudes and behavior concerning their oral health in comparison with healthy persons (p<0.001): they wash their teeth more rarely and in a shorter time, have less knowledge of oral diseases and their effect on general health, and visit their dentist more rarely. The obtained results depend on social, economic and demographic characteristics and on the underlying illness of patients. Conclusion. Health educational work concerning oral health of patients should be included in psychiatric treatment, as a part of an existing therapy with the aim of improving the general quality of their life.


2015 ◽  
Vol 17 (2) ◽  
pp. 121-136 ◽  
Author(s):  
Shaimaa Nasr Amin ◽  
Ahmed Amro El-Aidi ◽  
Mohamed Mostafa Ali ◽  
Yasser Mahmoud Attia ◽  
Laila Ahmed Rashed

PEDIATRICS ◽  
1966 ◽  
Vol 37 (2) ◽  
pp. 391-391
Author(s):  
JOHN F. CRIGLER

This "compact" report of a Ciba Study Group presents current information on (1) physiological mechanism of thyroid regulation by the hypothalamus and pituitary, including a discussion of the role of hypothalamic temperature responsive centers on thyroid activity; (2) the role of thyroid hormones in brain development; and (3) the effect of congenital hypothyroidism and of hyperthyroidism on neurological function with respect to intellect and behavior. The neurophysiological papers by Harris, Reichlin, and Anderson, dealing with our present knowledge of the source and nature of "thyrotropic-releasing factor" (TRF), and of the interrelation between the neutral and hormonal (thyroxine and the sympathomimetics) thermoregulatory factors involved in maintenance of thermal homeostasis, are factual, interesting and provocative.


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