Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward

Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is mixed. The morphologic and behavioral changes observed across many species predicted that deficits should be seen in humans, but identifying a phenotype of injury in children has been challenging. It is increasingly clear that in children, a brief or single early anesthetic exposure is not associated with deficits in a range of neurodevelopmental outcomes including broad measures of intelligence. Deficits in other domains including behavior, however, are more consistently reported in humans and also reflect findings from nonhuman primates. The possibility that behavioral deficits are a phenotype, as well as the entire concept of anesthetic neurotoxicity in children, remains a source of intense debate. The purpose of this report is to describe consensus and disagreement among experts, summarize preclinical and clinical evidence, suggest pathways for future clinical research, and compare studies of anesthetic agents to other suspected neurotoxins.

Linguistic injustice in academic publishing in English

In recent years, an intense debate in English for research publication purposes (ERPP) has developed around the question of whether linguistic injustice exists or not in academic publishing in English. In this Perspectives piece, I wish to engage in this debate by first situating the terms in which it is being developed, and then pointing out some of its limitations. In doing that, I argue that the view of language that is currently held in the debate seems problematic, and that a more explicit attention to the socially stratified nature of academic publishing seems missing from the debate. Suggesting potential ways forward, I propose that it seems crucial to adopt a view of language that anchors it more firmly as a social phenomenon, inherently connected to its speakers and the socially situated and stratified position that they inhabit. Remembering this is important in order to remain aware of the fact that both linguistic and non-linguistic factors are at play in shaping the uneven nature of academic publishing in English.

The nexus between the traditional system of governance and the local government system in Karamoja, Uganda

In the 1990s several countries in Africa adopted decentralisation policy reforms that coincided with a renewed interest in traditional institutions. This development has since sparked an intense debate on the compatibility of traditional systems of governance with decentralisation. The present article documents a case study conducted in Uganda’s Karamoja sub-region, a stronghold of traditionalism despite local government reforms. It concludes that although the traditional system of governance could help to link local communities with the modern local government system, the two structures have not been harmonised. Instead, they run on parallel and contradictory paths, which has had negative consequences for local governance and service delivery. The paper advocates blending the two to form a hybrid system in which they complement each other rather than being a source of conflict.

The Post-Postmodern Turn: Challenging the Application of Kuhn's Model

The point of departure for this article is the much-debated death of postmodernism, heralded by influential experts on the subject such as Linda Hutcheon or Ihab Hassan at the beginning of the new millennium. Although the academic community as a whole has not agreed with this fact, there was an intense debate during the first years of the twenty-first century that was evidence of a change of attitude towards this cultural phase. With this in mind, the aim of this study is to provide a theoretical framework for the change in order to understand its nature. Analysing the theories developed by Thomas S. Kuhn on paradigm shifts in the field of science and applying them to the context of critical theory at the beginning of the millennium serves to challenge the very idea of postmodernism as a paradigm in the terms developed in Kuhn’s The Structure of Scientific Revolutions.

Modeling Early Phases of COVID-19 Pandemic in Northern Italy and Its Implication for Outbreak Diffusion

The COVID-19 pandemic has sparked an intense debate about the hidden factors underlying the dynamics of the outbreak. Several computational models have been proposed to inform effective social and healthcare strategies. Crucially, the predictive validity of these models often depends upon incorporating behavioral and social responses to infection. Among these tools, the analytic framework known as “dynamic causal modeling” (DCM) has been applied to the COVID-19 pandemic, shedding new light on the factors underlying the dynamics of the outbreak. We have applied DCM to data from northern Italian regions, the first areas in Europe to contend with the outbreak, and analyzed the predictive validity of the model and also its suitability in highlighting the hidden factors governing the pandemic diffusion. By taking into account data from the beginning of the pandemic, the model could faithfully predict the dynamics of outbreak diffusion varying from region to region. The DCM appears to be a reliable tool to investigate the mechanisms governing the spread of the SARS-CoV-2 to identify the containment and control strategies that could efficiently be used to counteract further waves of infection.

Tracking excited state decay mechanisms of pyrimidine nucleosides in real time

DNA owes its remarkable photostability to its building blocks—the nucleosides—that efficiently dissipate the energy acquired upon ultraviolet light absorption. The mechanism occurring on a sub-picosecond time scale has been a matter of intense debate. Here we combine sub-30-fs transient absorption spectroscopy experiments with broad spectral coverage and state-of-the-art mixed quantum-classical dynamics with spectral signal simulations to resolve the early steps of the deactivation mechanisms of uridine (Urd) and 5-methyluridine (5mUrd) in aqueous solution. We track the wave packet motion from the Franck-Condon region to the conical intersections (CIs) with the ground state and observe spectral signatures of excited-state vibrational modes. 5mUrd exhibits an order of magnitude longer lifetime with respect to Urd due to the solvent reorganization needed to facilitate bulky methyl group motions leading to the CI. This activates potentially lesion-inducing dynamics such as ring opening. Involvement of the 1nπ* state is found to be negligible.

Whose Knowledge? Whose Influence? Changing Dynamics of China’s Development Cooperation Policy and Practice

This article aims to investigate the recent evolution of China’s development policy and practice. More precisely, how do China’s policymakers and practitioners understand and debate China’s role in international development, specifically in the context of the global Covid-19 pandemic? China’s growing development activities overseas, particularly in the African continent, have spurred intense debate over its role as a rising power in international development. China is viewed in the West both as a threat and as a valuable potential partner in development cooperation. However, differences between Western and Chinese conceptions of development have complicated cooperation and understanding of China’s development policy. Further understanding of these differences is needed, in order to evaluate their implications for low-income countries, and for potential trilateral cooperation.

Prompt and Long-Lived Anti-Kasha Emission from Organic Dyes

Anti-Kasha behavior has been the subject of intense debate in the last few years, as demonstrated by the high number of papers appearing in the literature on this topic, dealing with both mechanistic and applicative aspects of this phenomenon. Examples of anomalous emitters reported in the last 10 years are collected in the present review, which is focused on strictly anti-Kasha organic molecules displaying radiative deactivation from Sn and/or Tn, with n greater than 1.

Group Size and Peer Learning: Peer Discussions in Different Group Size Influence Learning in a Biology Exercise Performed on a Tablet With Stylus

Determining the optimal discussion group size to improve performance and learning has created an intense debate in psychology and provided mixed findings in laboratory and field settings. In a quasi-experimental study in the education field, we examined the effect of discussion group size on individual learning in a biology exercise performed on a tablet with stylus. The sample involved 102 secondary school students divided into four classes, each corresponding to one of the four experimental conditions (alone without peer discussion vs discussion in dyads vs triads vs four-member groups). They were asked to draw individually a functional schema of the human respiratory system, once before and once after discussing with peers (or reflecting alone). Both drawings were evaluated by four independent coders, and the learning gain for each student was computed from these evaluations. Results revealed that learning gain was greater for students discussing in four-member groups than for those in the other conditions. Additional analyses suggested that this effect was moderated by the students’ gender, with the learning gain being greater after discussion in four-member groups among females only. These findings suggest that group size of four individuals might be the optimal configuration to improve peer learning.

State Authority and Lynching in Latin America

Social scientists observed a significant increase in the number of lynchings in contemporary Latin America. The reasons for the rise are wide-ranging and conflicting. However, there are commonalities with the well-known cases of the United States of the nineteenth and twentieth centuries in which state legitimacy was the subject of intense debate. Therefore, this essay aims at observing why state intervention was deemed illegitimate in resolving local disputes that led to the vigilantes’ use of this form of extra-legal violence.