Fructooligosaccharides and wheat bran fed at similar fermentation levels differentially affect the expression of genes involved in transport, signaling, apoptosis, cell proliferation, and oncogenesis in the colon epithelia of healthy Fischer 344 rats

2019 ◽  
Vol 69 ◽  
pp. 101-113
Author(s):  
Qixuan Chen ◽  
Eleonora Swist ◽  
Morgan Kafenzakis ◽  
Jayadev Raju ◽  
Stephen P.J. Brooks ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wheat Bran ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Expression Of Genes

Interactive effects of methyl-deficiency and dietary restrictionon liver cell proliferation and telomerase activity in Fischer 344 rats pretreated with aflatoxin B1

2000 ◽  
Vol 152 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Ming W Chou ◽  
Marina V Mikhailova ◽  
Jasyl Nichols ◽  
Lionel A Poirier ◽  
Alan Warbritton ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cell ◽  
Aflatoxin B1 ◽  
Telomerase Activity ◽  
Interactive Effects ◽  
Fischer 344 Rats ◽  
Fischer 344

R403 – Epidermal Proliferating Cell Nuclear Antigen in Aging Rats

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P178-P178 ◽  
Author(s):  
Tapan K Bhattacharyya ◽  
Paula Jackson ◽  
J Regan Thomas
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferation Index ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Age Related ◽  
Two Parameters ◽  
Proliferating Cell ◽  
Effect Of Age

Problem To determine if epidermal cell proliferation in colony-raised Fischer 344 rats changes with age and diet. Methods Fischer 344 rats fed ad libitum and calorie-restricted (CR) diets were obtained from the NIA colonies, and young, young adult, and old animals from both groups were used for this study (six in each group). Tissue sections from the dorsal skin (DS) and foot plate (FP) were used for immunohistochemical staining of proliferating cell nuclear antigen (PCNA). The proliferation index (PCNA-I) was computed from counts of stained and total number of keratinocytes. Simultaneous measurements of epidermal thickness were obtained from same sections. Data were analyzed with Excel and SPSS 14.0 software for statistics. Results Two-way analysis of variance (ANOVA) was applied to the data to probe the effect of age, diet, and age-diet interaction. A significant effect of age was noticed in the two parameters i.e., DS PCNA (F 3.96, P .011), FP epidermal width (F 3.37, P .021) and FP PCNA-I (F 9.0, P .000). A significant correlation between DS width and PCNA values was also noted (r 0.5, P .01). Conclusion There is a trend of reduction of PCNA positive cells with increasing age irrespective of thickness of epidermis, and this trend is more apparent in CR rats. Significance This cell proliferation study has implications in relation to CR effect on age-related disease conditions, and biogerontology. Support The study was partially funded by the 2007 Leslie Bernstein grant from AAFPRS foundation.

Effect of caloric restriction on aflatoxin B1-induced DNA synthesis, AFB1-DNA binding and cell proliferation in Fischer 344 rats

1993 ◽  
Vol 70 (1-2) ◽  
pp. 23-33 ◽  
Author(s):  
Ming W. Chou ◽  
Ming H. Lu ◽  
Rex A. Pegram ◽  
Pu GaoShengfeng Cao ◽  
Jin Kong ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dna Binding ◽  
Dna Synthesis ◽  
Caloric Restriction ◽  
Aflatoxin B1 ◽  
Fischer 344 Rats ◽  
Fischer 344
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