Treatment of a high-angle Class I malocclusion with severe crowding and dental midline deviation: Soft tissue oriented treatment planning

2006 ◽  
Vol 65 (2) ◽  
pp. 88-93
Author(s):  
Wakako Tome ◽  
Seiji Haraguchi ◽  
Kohtaro Yashiro ◽  
Kenji Takada
Keyword(s):  
Soft Tissue ◽  
Treatment Planning ◽  
Class I ◽  
High Angle ◽  
Angle Class

scholarly journals Treatment of Angle class I malocclusion with severe crowding by extraction of four premolars: A case report

2018 ◽  
Vol 17 (4) ◽  
pp. 683-687
Author(s):  
Mohammad Khursheed Alam ◽  
Shifat A Nowrin ◽  
Fazal Shahid ◽  
Sanjida Haque ◽  
Anas Imran ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Medical Science ◽  
Class I ◽  
Orthodontic Appliances ◽  
Angle Class ◽  
Fixed Orthodontic Appliances ◽  
Canine Guidance ◽  
Bimaxillary Protrusion

Aims: To correct the Angle class I malocclusion with crowding via four premolar extractions.Presentation of case:A 19-year-old Malaysian female presented with the bimaxillary protrusion, crowding, high canines, midline deviation and edge-to-edge anterior bite. Upper lateral incisors were palatalized and in crossbite interactions with the opposite teeth.Discussion: Treatment was initiated using fixed orthodontic appliances followed by four 1st premolar extractions in both arches. Case was finished with good inter cuspation of the upper and lower teeth. Molars were finished in a Class I relationship with canine guidance, and ideal overjet and overbite were obtained.Conclusion: Successful finishing of a case with beautiful smile, obtained proper overjet and overbite, corrected cross bite, midline shifting and the improved soft tissue profile.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.683-687

scholarly journals Class I malocclusion with anterior crossbite and severe crowding

2014 ◽  
Vol 19 (2) ◽  
pp. 115-125 ◽  
Author(s):  
Daltro Enéas Ritter
Keyword(s):  
Treatment Planning ◽  
Female Patient ◽  
Orthodontic Treatment ◽  
Class I ◽  
Diagnosis And Treatment ◽  
Facial Profile ◽  
Angle Class ◽  
Dentofacial Orthopedics ◽  
Functional Complaints

This article reports the orthodontic diagnosis and treatment planning carried out with a 14-year and 5-month-old female patient with esthetic and functional complaints. She presented an Angle Class I malocclusion, anterior crossbite and severe crowding in both maxillary and mandibular arches, in addition to a lightly concave straight facial profile. Orthodontic treatment did not require extraction. Crossbite was corrected by protrusion of upper teeth, which contributed to alignment and leveling of teeth, in addition to improving the patient's facial profile. The case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the BBO certification.

scholarly journals The influence of erupting lateral teeth on maxillary anterior crowding in two Angle Class I maloclussion cases with high and low angles

2016 ◽  
Vol 6 ◽  
pp. 105-112
Author(s):  
Hiroshi Ueda ◽  
Morio Masunaga ◽  
Cynthia Concepcion ◽  
Kazuo Tanne
Keyword(s):  
Class I ◽  
Occlusal Plane ◽  
Dental Arch ◽  
High Angle ◽  
Treatment Progress ◽  
Anterior Crowding ◽  
Skeletal Class ◽  
Second Stage ◽  
Angle Class ◽  
Frankfurt Horizontal

Two cases of anterior crowding, both Skeletal Class I and Angle Class I maloclussion, one being low angle and the other high angle respectively, respectively, were treated and evaluated to ascertain whether or not there is a relationship among disproportionate mesial axial angulation of the maxillary lateral teeth and the Frankfurt Horizontal- Functional Occlusal plane, therefore generating maxillary anterior crowding. Both cases were Japanese boys, the first one aged 9 years 10 months with chief complaint being anterior crowding and the second case aged 7 years and 8 months complaining of inadequate space for satisfying canine eruption. During and after the second stage of orthodontic treatment on both cases, several radiographic analysis were performed to assess treatment progress and retention; from these radiographs, it was noticed among other findings that in the high-angle case, the axial angulations of the maxillary lateral incisors were markedly smaller than in the low-angle case, thus indicating mesial tipping in the upper dental arch. This decreased mesial axial angulation of the lateral teeth observed at high angles may potentially cause maxillary space deficiency.

scholarly journals Conservative treatment of a Class I malocclusion with 12 mm overjet, overbite and severe mandibular crowding

2012 ◽  
Vol 17 (5) ◽  
pp. 43-52
Author(s):  
Marcos Alan Vieira Bittencourt ◽  
Arthur Costa Rodrigues Farias ◽  
Marcelo de Castellucci e Barbosa
Keyword(s):  
Class I ◽  
Facial Features ◽  
Conservative Approach ◽  
Upper Lip ◽  
Facial Aesthetics ◽  
Lower Lip ◽  
Angle Class ◽  
Nasolabial Angle ◽  
Lower Arch ◽  
Lower Incisors

INTRODUCTION: A female patient aged 12 years and 2 months had molars and canines in Class II relationship, severe overjet (12 mm), deep overbite (100%), excessive retroclination and extrusion of the lower incisors, upper incisor proclination, with mild midline diastema. Both dental arches appeared constricted and a lower arch discrepancy of less than -6.5 mm. Facially, she had a significant upper incisors display at rest, interposition and eversion of the lower lip, acute nasolabial angle and convex profile. OBJECTIVE: To report a clinical case consisting of Angle Class I malocclusion with deep overbite and overjet in addition to severe crowding treated with a conservative approach. METHODS: Treatment consisted of slight retraction of the upper incisors and intrusion and protrusion of the lower incisors until all crowding was eliminated. RESULTS: Adequate overbite and overjet were achieved while maintaining the Angle Class I canine and molar relationships and coincident midlines. The facial features were improved, with the emergence of a slightly convex profile and lip competence, achieved through a slight retraction of the upper lip and protrusion of the lower lip, while improving the nasolabial and mentolabial sulcus. CONCLUSIONS: This conservative approach with no extractions proved effective and resulted in a significant improvement of the occlusal relationship as well as in the patient's dental and facial aesthetics.

scholarly journals Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma

2021 ◽  
Vol 9 (2) ◽  
pp. e001696
Author(s):  
Yi Que ◽  
Xiao-Long Zhang ◽  
Ze-Xian Liu ◽  
Jing-Jing Zhao ◽  
Qiu-Zhong Pan ◽  
...  
Keyword(s):  
Cell Death ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Programmed Cell Death ◽  
Gene Family ◽  
Murine Model ◽  
Immune Checkpoint ◽  
Drug Target ◽  
Class I ◽  
Mechanistic Study

BackgroundThe advent of immune checkpoint therapy has been a tremendous advance in cancer treatment. However, the responses are still insufficient in patients with soft tissue sarcoma (STS). We aimed to identify rational combinations to increase the response to immune checkpoint therapy and improve survival.MethodsWhole-exome sequencing (WES) was performed in 11 patients with liposarcoma. Somatic copy number alterations (SCNAs) were analyzed at the gene level to identify obvious amplification patterns in drug-target genes. The expression and prognostic value of class I histone deacetylases (HDACs) was evaluated in 49 patients with sarcoma in our center and confirmed in 263 sarcoma samples from The Tumor Cancer Genome Atlas (TCGA) database. Q-PCR, flow cytometry and RNA-seq were performed to determine the correlations between class I HDACs, chidamide and PD-L1 in vitro and in vivo. The efficacy of combining chidamide with PD-1 blockade was explored in an immunocompetent murine model and a small cohort of patients with advanced sarcoma. Western blot, ChIP assay and dual luciferase assessment were applied in the mechanistic study.ResultsThe HDAC gene family was frequently amplified in STS. SCNAs in the HDAC gene family were extensively amplified in 8 of 11 (73%) patients with liposarcoma, based on a drug-target gene set, and we verified amplification in 76.65% (197/257) of cases by analyzing TCGA sarcoma cohort. Class I HDAC expression is associated with a poor prognosis for patients with STS, and its inhibition is responsible for promoting apoptosis and upregulating of programmed cell death ligand 1 (PD-L1). The HDAC class I inhibitor chidamide significantly increases PD-L1 expression, increased the infiltration of CD8+ T cells and reduced the number of MDSCs in the tumor microenvironment. The combination of chidamide with an anti-PD-1 antibody significantly promotes tumor regression and improves survival in a murine model. Moreover, chidamide combined with the anti-PD-1 antibody toripalimab is effective in patients with advanced and metastatic sarcoma, and the side effects are tolerable. Mechanistically, chidamide increases histone acetylation at the PD-L1 gene through the activation of the transcriptional factor STAT1.ConclusionsThe combination of chidamide and anti-programmed cell death 1 (PD-1) therapy represents a potentially important strategy for STS.

scholarly journals A proof of concept treatment planning study of gated proton radiotherapy for cardiac soft tissue sarcoma

2021 ◽  
Vol 19 ◽  
pp. 78-84
Author(s):  
Hyeri Lee ◽  
Jennifer Pursley ◽  
Hsiao-Ming Lu ◽  
Judith Adams ◽  
Thomas DeLaney ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Treatment Planning ◽  
Proof Of Concept ◽  
Proton Radiotherapy ◽  
Planning Study

Distribution and Prognostic Significance of Papillomavirus Binding Factor and HLA-Class I in Osteosarcoma and Other Bone and Soft-Tissue Sarcomas

2005 ◽  
Vol 28 (6) ◽  
pp. 660
Author(s):  
Tomohide Tsukahara ◽  
Satoshi Kawaguchi ◽  
Toshihiko Torigoe ◽  
Kumiko Shimozawa ◽  
Emiri Nakazawa ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Prognostic Significance ◽  
Soft Tissue Sarcomas ◽  
Hla Class I ◽  
Class I ◽  
Binding Factor

scholarly journals Comparison of Tooth Widths, Arch Widths and Arch Lengths in Class-I Normal Dentition to Class-I and II Crowded Dentitions

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Hafiza Zobia Shafique ◽  
Rumeesha Zaheer ◽  
Abdullah Jan ◽  
Ayesha Fazal
Keyword(s):  
Treatment Planning ◽  
Armed Forces ◽  
Class Ii ◽  
Vital Role ◽  
Class I ◽  
Permanent Teeth ◽  
Creative Commons ◽  
Normal Occlusion ◽  
Complete Set ◽  
Open Access Article

Background and Objective: Dental study casts play a vital role in the diagnosis and treatment planning of various orthodontic cases. This study was carried out to compare the tooth widths, arch widths, and arch lengths in Class-I normal dentition to those in Class-I and Class-II crowded dentition in an effort to improve treatment planning and to eventually reduce treatment duration. Methods: Total 170 patients, 12 to 40 years of age with a complete set of permanent teeth till 1st molars; who presented to the Orthodontics Department at Armed Forces Institute of Dentistry (A.F.I.D), Rawalpindi from Sep 2019 to Feb 2020, were included in the study. Non-probability purposive method of sampling was used. The dental casts obtained were used to measure tooth widths, arch widths, and arch lengths. Subjects were classified into Class-I normal and Class-I and Class-II crowded occlusion and comparison of the sum of tooth widths, arch widths, and arch length discrepancies were determined among the three occlusion groups. Data was analyzed in SPSS version 21 and independent samples t-test was used to differentiate the variables of interest. Results: Out of 170 subjects, 73 (42.9%) subjects had Class-I normal occlusion while 97 (57%) had Class-I and Class-II crowded occlusions. No statistical difference was found between the occlusal groups with regard to the sum of tooth widths, inter-canine widths, inter-first premolar widths, inter-second premolar widths and inter-molar widths. However, a remarkable difference was observed between the occlusal groups with respect to arch perimeters and arch length discrepancies (p = 0.000 and 0.000 respectively). Conclusions: Results of the current study indicate that crowding of teeth occurs as a consequence of decreased arch perimeters which may lead to increased arch length discrepancies. However, no prominent difference was noticed in the sum of tooth widths and arch widths among different occlusal groups. doi: https://doi.org/10.12669/pjms.37.2.3240 How to cite this:Shafique HZ, Zaheer R, Jan A, Fazal A. Comparison of Tooth Widths, Arch Widths and Arch Lengths in Class-I Normal Dentition to Class-I and II Crowded Dentitions. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3240 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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