PD1. Molecular analysis of salivary rinses as an independent prognostic indicator in head and neck cancer

A prospective study into the nutritional status of 114 patients with untreated primary squamous cell carcinoma of the head and neck was undertaken to assess its possible prognostic value for survival. Nutritional status was evaluated by anthropometry, creatinine height index estimation, serum albumin and transferrin assays, and nitrogen balance studies. Weight change and other anthropometric indices found to be the most reliable nutritional parameters were averaged to derive a clinically useful, general nutritional status score. A nutritional deficit was found in 43 of the 114 patients (37.7%) and was associated with neoplasms of the upper gastrointestinal tract in more than 80% of the patients. Life table analysis showed a statistically very highly significant difference between the survival of the adequately nourished patients (57.5% at 2 years) and the survival of the undernourished patients (7.5% at 2 years) (χ2 = 36.08; P = .0). These results indicate that nutritional deficiency is an important adverse prognostic factor in head and neck cancer. Undernutrition probably exerts its effect, at least in part, by causing secondary immunologic dysfunction.

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The Value of Cardiopulmonary Exercise Testing As A Prognostic Indicator For Head And Neck Cancer Patients Considered For Primary Surgery

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.bjoms.2018.10.177 ◽

2018 ◽

Vol 56 (10) ◽

pp. e62

Author(s):

Nicole Fernandes ◽

Mohammed Hussain ◽

Michael Ho ◽

Anastasios Kanatas ◽

Gillon Fabbroni ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Exercise Testing ◽

Cardiopulmonary Exercise Testing ◽

Prognostic Indicator ◽

Cardiopulmonary Exercise ◽

Primary Surgery

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Reply to pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer

Cancer ◽

10.1002/cncr.29849 ◽

2015 ◽

Vol 122 (6) ◽

pp. 972-973

Author(s):

Jong-Lyel Roh ◽

Shin-Ae Kim

Keyword(s):

Head And Neck Cancer ◽

Nutritional Status ◽

Head And Neck ◽

Neck Cancer ◽

Prognostic Indicator

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Interleukin-2 Release from Lymphocytes of Patients with Head and Neck Cancer

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948909800303 ◽

1989 ◽

Vol 98 (3) ◽

pp. 179-184 ◽

Cited By ~ 6

Author(s):

Thomas P. U. Wustrow ◽

Dieter Kabelitz

Keyword(s):

Head And Neck Cancer ◽

T Cell ◽

Head And Neck ◽

Neck Cancer ◽

Interleukin 2 ◽

Prognostic Indicator ◽

Cytotoxic T Cell ◽

Patients With Cancer ◽

Control Subjects

Interleukin-2 (IL-2) plays a central role in cellular immune regulation. In vitro this cytokine is secreted after mitogenic stimulation with phorbolester (PMA), phytohemagglutinin A (PHA), or the monoclonal T cell antibody OKT3. In our experiments the IL-2 concentration was measured in a biologic system using an IL-2-dependent murine cytotoxic T cell line. Control subjects who were age-matched to patients with head and neck cancers did not show an altered IL-2 production in vitro, irrespective of whether they were accustomed to high alcohol consumption or cigarette smoking. Patients with cancer of the larynx did not differ significantly from control subjects. Most prominent was the significant reduction in IL-2 release of patients with cancer of the oropharynx and in patients with positive lymph nodes in the neck. Impaired IL-2 secretion in head and neck cancer patients may therefore be an additional prognostic indicator worthy of further investigation.

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