Cardiovascular Risk Factors for Retinal Vein Occlusion and Arteriolar EmboliThe Atherosclerosis Risk in Communities & Cardiovascular Health studies

Ophthalmology ◽  
2005 ◽  
Vol 112 (4) ◽  
pp. 540-547 ◽  
Author(s):  
T WONG ◽  
E LARSEN ◽  
R KLEIN ◽  
P MITCHELL ◽  
D COUPER ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Cardiovascular Health ◽  
Atherosclerosis Risk In Communities ◽  
Vein Occlusion ◽  
Atherosclerosis Risk ◽  
Health Studies

Education and Cardiovascular Health as Effect Modifiers of APOE ε4 on Dementia: The Atherosclerosis Risk in Communities (ARIC) Study

2021 ◽  
Author(s):  
Mark Lee ◽  
Timothy M Hughes ◽  
Kristen M George ◽  
Michael E Griswold ◽  
Sanaz Sedaghat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cardiovascular Health ◽  
Apoe Genotype ◽  
Protective Effects ◽  
Atherosclerosis Risk In Communities ◽  
Dementia Risk ◽  
Incident Dementia ◽  
Atherosclerosis Risk

Abstract Background Both education and cardiovascular risk factors are strongly associated with dementia risk. However, it is not clear whether these associations persist or vary among individuals with high genetic risk for Alzheimer’s Disease. We examined the interactive relationship between lifestyle and genetic dementia risk factors in a prospective cohort study. Methods Our data came from the Atherosclerosis Risk in Communities study participants (n=13,715; baseline age 45-64; 25% Black; 55% female), who were followed for incident dementia from 1987 through 2017. We used Cox proportional hazard models to estimate the risk of dementia (ascertained through in-person examination, telephone cognitive screeners, and/or hospital and death records) associated with baseline education and cardiovascular risk factors (measured using the American Heart Association’s “Life Simple 7”) among ε4 carriers and non-carriers separately. We also examined differences by race and sex. Results 2,226 incident dementia cases occurred over a median 25 years of follow-up. Lower educational attainment and poorer cardiovascular health were associated with greater risk of incident dementia. There was an education by APOE status interaction (p=0.005) whereby the association of education and dementia was weaker for ε4 carriers (HR college graduates vs. less than high school: 0.71 (0.59-0.84) than non-carriers (0.54 (0.47-0.63)). There was no interaction between APOE status and cardiovascular health on dementia risk. These relationships did not vary significantly by race or sex. Conclusions Education and cardiovascular health were associated with lower dementia risk regardless of APOE genotype, though the protective effects of education were somewhat diminished among ε4 carriers.

Cardiovascular risk factors and outcome in patients with retinal vein occlusion

2009 ◽  
Vol 30 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Mirko Di Capua ◽  
Antonio Coppola ◽  
Rosina Albisinni ◽  
Antonella Tufano ◽  
Anna Guida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Vein Occlusion

Coagulation disorders and the risk of retinal vein occlusion

2010 ◽  
Vol 103 (02) ◽  
pp. 299-305 ◽  
Author(s):  
Inge Scharrer ◽  
Marc Lüchtenberg ◽  
Lars-Olof Hattenbach ◽  
Claudia Kuhli-Hattenbach
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Family History ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Thromboembolic Event ◽  
Strong Predictor ◽  
Coagulation Disorders ◽  
Vein Occlusion ◽  
History Of

SummaryOver the past years, there has been a dramatic increase in the number of identifiable causes of thrombophilia. However, to date, there are no large, prospective studies to assess an optimal, cost-effective approach with regard to screening and case finding for thrombophilic risk factors in patients presenting with retinal vessel occlusion. Two hundred twenty-eight patients with retinal vein occlusion (RVO) and 130 age-matched healthy controls were prospectively screened for thrombophilic risk factors. Both cohorts were divided into three subgroups, depending on the patients‘ age at the time of the RVO or a previous thromboembolic event. Patient age ≤45 years was associated with a high prevalence of coagulation disorders (p<0.0001). Among patients ≤45 years and >45 to ≤60 years, a family history of thromboembolism was strongly associated with the presence of thrombophilic disorders. The absence of cardiovascular risk factors was found to be a strong predictor for the presence of coagulation disorders in all patient groups (≤45 years, p=0.003; >45 to ≤60 years, p=0.0008; >60 years, p=0.001). Multivariate analysis revealed the presence of resistance to activated protein C (p=0.014), antiphospholipid antibodies (p=0.022), and deficiency of the anticoagulant proteins (p=0.05) as independent risk factors for the development of RVO among patients ≤45 years. Our results indicate that thrombophilic disorders are associated with the development of retinal vein occlusion in patients ≤45 years by the time of the RVO or a previous thromboembolic event, in patients with a family history of thromboembolism, or in patients without cardiovascular risk factors.

Thrombophilic and cardiovascular risk factors for retinal vein occlusion

2017 ◽  
Vol 44 ◽  
pp. 44-48 ◽  
Author(s):  
Paolo Bucciarelli ◽  
Serena M. Passamonti ◽  
Francesca Gianniello ◽  
Andrea Artoni ◽  
Ida Martinelli
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Vein Occlusion

Cardiovascular risk factors, nonvalvular atrial fibrillation and retinal vein occlusion

2017 ◽  
Vol 217 (4) ◽  
pp. 188-192
Author(s):  
M. Lisa Gracia ◽  
A. Córdoba Alonso ◽  
J.L. Hernández Hernández ◽  
R. Pérez Montes ◽  
J.J. Napal Lecumberri
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Nonvalvular Atrial Fibrillation ◽  
Vein Occlusion

scholarly journals Traditional and Novel Cardiovascular Risk Factors for Retinal Vein Occlusion: The Multiethnic Study of Atherosclerosis

2008 ◽  
Vol 49 (10) ◽  
pp. 4297 ◽  
Author(s):  
Ning Cheung ◽  
Ronald Klein ◽  
Jie Jin Wang ◽  
Mary Frances Cotch ◽  
Amirul F. M. Islam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Retinal Vein Occlusion ◽  
Vein Occlusion
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