scholarly journals Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study

2017 ◽  
Vol 102 (9) ◽  
pp. 3306-3315 ◽  
Author(s):  
Seth S Martin ◽  
Natalie Daya ◽  
Pamela L Lutsey ◽  
Kunihiro Matsushita ◽  
Anna Fretz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Thyroid Function ◽  
Atherosclerotic Cardiovascular Disease ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

Abstract P111: Serum and Dietary Magnesium and the Incidence of Atrial Fibrillation in Whites and African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jeffrey R Misialek ◽  
Faye L Lopez ◽  
Rachel R Huxley ◽  
James M Peacock ◽  
Lin Y Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Cardiovascular Risk Factors ◽  
Serum Magnesium ◽  
The United States ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

Background: Low serum magnesium (Mg) has been associated with a higher cardiovascular risk and other cardiovascular diseases (CVD) including ventricular arrhythmias. However, the association between serum or dietary Mg and atrial fibrillation (AF) has not been investigated to date. Methods: We studied 14,290 men and women (75% white, 53% women, mean age 54) free of AF at baseline participating in the Atherosclerosis Risk in Communities (ARIC) study, a community-based cohort in the United States. Serum Mg was assessed at baseline (1987-89) and a second visit (1990-92) while dietary Mg was assessed at baseline and a third visit (1993-95). The mean value of two Mg measurements were used for individuals who attended both visits while the baseline Mg measurement was used for individuals who did not attend another visit or were censored. Incident AF cases through 2008 were ascertained from electrocardiograms, hospital discharge codes, and death certificates. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals for AF associated with serum and dietary Mg quintiles. Models were initially adjusted for age, sex, race, and ARIC field center, and additional models further adjusted for other cardiovascular risk factors and prevalent CVD. Dietary Mg analyses included correlated dietary covariates in all models. Interaction by race and sex was tested for serum and dietary Mg. Results: Over a median follow-up time of 19.7 years, 1,613 incident AF cases were identified. Higher serum Mg was associated with lower AF risk even after adjustment for cardiovascular risk factors and other CVD (table), with no evidence of significant interactions between serum Mg and sex or race. No significant association was identified between dietary Mg and AF. Conclusion: High serum Mg was associated with a lower AF risk, and this association was not different between whites and African Americans. Dietary Mg was not associated with AF risk. Funding(This research has received full or partial funding support from the American Heart Association, National Center)

scholarly journals Risk of Cardiovascular Disease among Diabetic Patients in Manipur, Northeast India

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mary Grace Tungdim ◽  
T. Ginzaniang ◽  
G. Poufullung Kabui ◽  
Deepali Verma ◽  
Satwanti Kapoor
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Premature Mortality ◽  
Northeast India ◽  
Risk Level ◽  
Diabetic Patients ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional

Atherosclerotic cardiovascular disease is the major cause of premature mortality in patients with type 2 diabetes. The present study was conducted to assess cardiovascular risk among diabetic patients of Northeast India. The present cross-sectional study included 81 diabetic patients (39 males and 42 females) aged 36–74 years from the district Imphal of Manipur, Northeast India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10-year risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level. Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.3% patients were at high risk, 37.0% at moderate risk and 24.7% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride, and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications, taking into consideration the traditional dietary pattern of the population.

Education and Cardiovascular Health as Effect Modifiers of APOE ε4 on Dementia: The Atherosclerosis Risk in Communities (ARIC) Study

2021 ◽  
Author(s):  
Mark Lee ◽  
Timothy M Hughes ◽  
Kristen M George ◽  
Michael E Griswold ◽  
Sanaz Sedaghat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cardiovascular Health ◽  
Apoe Genotype ◽  
Protective Effects ◽  
Atherosclerosis Risk In Communities ◽  
Dementia Risk ◽  
Incident Dementia ◽  
Atherosclerosis Risk

Abstract Background Both education and cardiovascular risk factors are strongly associated with dementia risk. However, it is not clear whether these associations persist or vary among individuals with high genetic risk for Alzheimer’s Disease. We examined the interactive relationship between lifestyle and genetic dementia risk factors in a prospective cohort study. Methods Our data came from the Atherosclerosis Risk in Communities study participants (n=13,715; baseline age 45-64; 25% Black; 55% female), who were followed for incident dementia from 1987 through 2017. We used Cox proportional hazard models to estimate the risk of dementia (ascertained through in-person examination, telephone cognitive screeners, and/or hospital and death records) associated with baseline education and cardiovascular risk factors (measured using the American Heart Association’s “Life Simple 7”) among ε4 carriers and non-carriers separately. We also examined differences by race and sex. Results 2,226 incident dementia cases occurred over a median 25 years of follow-up. Lower educational attainment and poorer cardiovascular health were associated with greater risk of incident dementia. There was an education by APOE status interaction (p=0.005) whereby the association of education and dementia was weaker for ε4 carriers (HR college graduates vs. less than high school: 0.71 (0.59-0.84) than non-carriers (0.54 (0.47-0.63)). There was no interaction between APOE status and cardiovascular health on dementia risk. These relationships did not vary significantly by race or sex. Conclusions Education and cardiovascular health were associated with lower dementia risk regardless of APOE genotype, though the protective effects of education were somewhat diminished among ε4 carriers.

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