Benign and Low Grade Serous Epithelial Tumors: Recent Developments and Diagnostic Problems

2011 ◽  
Vol 4 (1) ◽  
pp. 331-373 ◽  
Author(s):  
Teri A. Longacre
Keyword(s):  
Low Grade ◽  
Diagnostic Problems ◽  
Epithelial Tumors ◽  
Recent Developments

A Diskogenic Dural Defect is the Reason for the Ventral Location of the Epidural Spinal Fluid Collection Seen in Superficial Siderosis

2021 ◽  
pp. 10.1212/CPJ.0000000000001085
Author(s):  
Neeraj Kumar
Keyword(s):  
Fluid Collection ◽  
Initial Point ◽  
Spinal Fluid ◽  
Superficial Siderosis ◽  
Low Grade ◽  
Dural Defect ◽  
Dynamic Ct ◽  
Contrast Extravasation ◽  
Recent Developments ◽  
Dural Defects

AbstractPurpose of reviewSuperficial siderosis (SS) of the nervous system is often due to a dural pathology. This review focuses on recent developments related to the management of this subgroup of SS patients.Recent findingsThe presence of an epidural ventral spinal fluid collection in patients with SS is a clue to the presence of a diskogenic dural defect. The location of the defect is ascertained by a dynamic CT-myelogram which involves placing the patient in a prone position with hips elevated. This permits gravity assisted preferential ventral localization of the contrast and active scanning during contrast injection facilitates a precise delineation of the initial point of contrast extravasation which localizes the defect.SummaryDiskogenic dural defects are commonly the underlying etiology for SS in patients with a ventral spinal fluid collection. A dynamic CT-myelogram facilitates detection and subsequent repair of these defects which arrests the continued low-grade subarachnoid bleeding.

Diagnostic problems of epithelial tumors of penis

Urology ◽  
1977 ◽  
Vol 9 (1) ◽  
pp. 79-82 ◽  
Author(s):  
A.M.B. Goldstein ◽  
W.F. Reynolds ◽  
R. Terry
Keyword(s):  
Diagnostic Problems ◽  
Epithelial Tumors

scholarly journals Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations

2014 ◽  
Vol 60 (7) ◽  
pp. 1004-1011 ◽  
Author(s):  
Xiaoying Liu ◽  
Kabir Mody ◽  
Francine B de Abreu ◽  
J Marc Pipas ◽  
Jason D Peterson ◽  
...  
Keyword(s):  
Pseudomyxoma Peritonei ◽  
Somatic Mutations ◽  
Massively Parallel Sequencing ◽  
Janus Kinase ◽  
Molecular Heterogeneity ◽  
Low Grade ◽  
Viral Oncogene ◽  
Mutational Spectra ◽  
Epithelial Tumors ◽  
Viral Oncogene Homolog

Abstract BACKGROUND Some epithelial neoplasms of the appendix, including low-grade appendiceal mucinous neoplasm and adenocarcinoma, can result in pseudomyxoma peritonei (PMP). Little is known about the mutational spectra of these tumor types and whether mutations may be of clinical significance with respect to therapeutic selection. In this study, we identified somatic mutations using the Ion Torrent AmpliSeq Cancer Hotspot Panel v2. METHODS Specimens consisted of 3 nonneoplastic retention cysts/mucocele, 15 low-grade mucinous neoplasms (LAMNs), 8 low-grade/well-differentiated mucinous adenocarcinomas with pseudomyxoma peritonei, and 12 adenocarcinomas with/without goblet cell/signet ring cell features. Barcoded libraries were prepared from up to 10 ng of extracted DNA and multiplexed on single 318 chips for sequencing. Data analysis was performed using Golden Helix SVS. Variants that remained after the analysis pipeline were individually interrogated using the Integrative Genomics Viewer. RESULTS A single Janus kinase 3 (JAK3) mutation was detected in the mucocele group. Eight mutations were identified in the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and GNAS complex locus (GNAS) genes among LAMN samples. Additional gene mutations were identified in the AKT1 (v-akt murine thymoma viral oncogene homolog 1), APC (adenomatous polyposis coli), JAK3, MET (met proto-oncogene), phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA), RB1 (retinoblastoma 1), STK11 (serine/threonine kinase 11), and tumor protein p53 (TP53) genes. Among the PMPs, 6 mutations were detected in the KRAS gene and also in the GNAS, TP53, and RB1 genes. Appendiceal cancers showed mutations in the APC, ATM (ataxia telangiectasia mutated), KRAS, IDH1 [isocitrate dehydrogenase 1 (NADP+)], NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog], PIK3CA, SMAD4 (SMAD family member 4), and TP53 genes. CONCLUSIONS Our results suggest molecular heterogeneity among epithelial tumors of the appendix. Next generation sequencing efforts have identified mutational spectra in several subtypes of these tumors that may suggest a phenotypic heterogeneity showing mutations that are relevant for targeted therapies.

scholarly journals Application of dry high-intensity magnetic separation in upgrading low-grade iron ore of Rouina deposit, Algeria

2020 ◽  
Vol 56 (1) ◽  
pp. 47-58
Author(s):  
A. Messai ◽  
A. Idres ◽  
J.M. Menendez-Aguado
Keyword(s):  
Magnetic Separation ◽  
High Intensity ◽  
Iron Ore ◽  
Size Fraction ◽  
Cement Industry ◽  
Raw Material ◽  
Low Grade ◽  
Iron Ores ◽  
Mineralogical Characterization ◽  
Recent Developments

The recent developments of steel and iron industries generated a huge consumption of iron ores which has attracted much attention for utilizing low-grade iron resources to satisfy this increasing demand. The present study focuses on the characterization and enrichment of the low-grade iron ores from Rouina deposit-Ain Defla-. Currently, the ore is used in the cement industry because it is considered a low-grade iron ore. After the sampling process, a physico-chemical and mineralogical characterization was carried out and the results revealed that the sample consists of hematite, limonite and goethite as major opaque oxide minerals whereas silicates as well as clays form the gangue minerals in the sample. The average grade of FeTotal, SiO2 and Al2O3 contents in the raw material collected from the mine of the case study are 30.85%, 23.12% and 7.77% respectively. Processes involving combination of classification, washing and dry high-intensity magnetic separation were carried out to upgrade the low-grade iron ore sample to make it suitable as a marketable product. The sample was first ground and each closed size sieve fractions were subjected to washing followed by drying than dry high intensity magnetic separation and it was observed that limited upgradation is possible. As a result, it was possible to obtain a magnetic concentrate of 54.09% with a recovery degree of 89.30% and yield of 62.82% using a magnetic field intensity equal to 2.4 Tesla at the size fraction [-0.125 +0.063 mm].

scholarly journals Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2515 ◽  
Author(s):  
Marleen M. J. van Greevenbroek ◽  
Casper G. Schalkwijk ◽  
Coen D.A. Stehouwer
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Low Grade ◽  
Pharmacological Interventions ◽  
Obesity Epidemic ◽  
The Metabolic Syndrome ◽  
Adipose Tissue Dysfunction ◽  
Recent Developments ◽  
Low Grade Inflammation ◽  
The Complement System

The ongoing worldwide obesity epidemic makes the metabolic syndrome an increasingly important entity. In this review, we provide a short background on the metabolic syndrome, we discuss recent developments in the three main options that have been identified for intervention in the metabolic syndrome, i.e. lifestyle and surgical and pharmacological interventions, and we focus on different views in the literature and also include our own viewpoints on the metabolic syndrome. In addition, we discuss some emerging treatment targets for adipose tissue dysfunction and low-grade inflammation, i.e. activation of the inflammasome and the complement system, and consider some selected opportunities for intervention in these processes.

scholarly journals Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors

2015 ◽  
Vol 7 (2) ◽  
pp. 61-63
Author(s):  
Ganga S Pilli ◽  
Prakash V Patil ◽  
SG Karadesai
Keyword(s):  
Prognostic Indicator ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
P Value ◽  
Low Grade ◽  
High Grade ◽  
Osteopontin Expression ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors ◽  
Ovarian Cancers

ABSTRACT Aim To determine if osteopontin expression by immunohistochemistry (IHC) can correlate with histological type and grade of epithelial ovarian cancer. Materials and methods The present work has been carried out at department of pathology, of a reputed medical college in Belgaum district of Karnataka state. The study is carried out for a period of 18 months for data collection, evaluation of the marker and data analysis. All consecutive specimens of ovarian tumors are included in the study. The study included 55 epithelial ovarian tumors and these are analyzed histopathologically. In all the cases, osteopontin expression has been studied with IHC on paraffin slides. Results This study included 41 (74.5%) benign tumors and 14 (25.5%) malignant tumors. High grade (grade III) was common in serous carcinomas than in other histological types. Fisher's exact test p-value < 0.001 was significant for expression of osteopontin and all the malignant ovarian epithelial tumors expressed osteopontin by IHC procedure on paraffin tissue sections. All high-grade epithelial ovarian tumors showed increased expression of osteopontin of +++ and low-grade tumors expressed +/++osteopontin. Conclusion The osteopontin expression was seen in all the malignant epithelial ovarian cancers and the osteopontin expression was significantly higher in high-grade epithelial ovarian cancers than low-grade epithelial ovarian cancers. How to cite this article Pilli GS, Patil PV, Karadesai SG. Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors. J South Asian Feder Obst Gynae 2015;7(2): 61-63.

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