scholarly journals An interpretable deep-learning model for early prediction of sepsis in the emergency department

Patterns ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 100196
Author(s):  
Dongdong Zhang ◽  
Changchang Yin ◽  
Katherine M. Hunold ◽  
Xiaoqian Jiang ◽  
Jeffrey M. Caterino ◽  
...  
2020 ◽  
Author(s):  
Dongdong Zhang ◽  
Changchang Yin ◽  
Katherine M. Hunold ◽  
Xiaoqian Jiang ◽  
Jeffrey M. Caterino ◽  
...  

Background: Sepsis, a life-threatening illness caused by the body's response to an infection, is the leading cause of death worldwide and has become a global epidemiological burden. Early prediction of sepsis increases the likelihood of survival for septic patients. Methods The 2019 DII National Data Science Challenge enabled participating teams to develop models for early prediction of sepsis onset with de-identified electronic health records of over 100,000 unique patients. Our task is to predict sepsis onset 4 hours before its diagnosis using basic administrative and demographics, time-series vital, lab, nutrition as features. An LSTM-based model with event embedding and time encoding is proposed to model time-series prediction. We utilized the attention mechanism and global max pooling techniques to enable interpretation for the proposed deep learning model. Results We evaluated the performance of the proposed model on 2 use cases of sepsis onset prediction which achieved AUC scores of 0.940 and 0.845, respectively. Our team, BuckeyeAI achieved an average AUC of 0.892 and the official rank is #2 out of 30 participants. Conclusions Our model outperformed collapsed models (i.e., logistic regression, random forest, and LightGBM). The proposed LSTM-based model handles irregular time intervals by incorporating time encoding and is interpretable thanks to the attention mechanism and global max pooling techniques.


2020 ◽  
Vol 13 (4) ◽  
pp. 627-640 ◽  
Author(s):  
Avinash Chandra Pandey ◽  
Dharmveer Singh Rajpoot

Background: Sentiment analysis is a contextual mining of text which determines viewpoint of users with respect to some sentimental topics commonly present at social networking websites. Twitter is one of the social sites where people express their opinion about any topic in the form of tweets. These tweets can be examined using various sentiment classification methods to find the opinion of users. Traditional sentiment analysis methods use manually extracted features for opinion classification. The manual feature extraction process is a complicated task since it requires predefined sentiment lexicons. On the other hand, deep learning methods automatically extract relevant features from data hence; they provide better performance and richer representation competency than the traditional methods. Objective: The main aim of this paper is to enhance the sentiment classification accuracy and to reduce the computational cost. Method: To achieve the objective, a hybrid deep learning model, based on convolution neural network and bi-directional long-short term memory neural network has been introduced. Results: The proposed sentiment classification method achieves the highest accuracy for the most of the datasets. Further, from the statistical analysis efficacy of the proposed method has been validated. Conclusion: Sentiment classification accuracy can be improved by creating veracious hybrid models. Moreover, performance can also be enhanced by tuning the hyper parameters of deep leaning models.


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