Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins

During early differentiation starving Dictyostelium discoideum amoebae produce a burst of light that is enhanced by heat shock at the beginning of development. We report here pharmacological, genetic and spectral evidence that the chemiluminescence results from lipid peroxidation reactions following oxygen reduction by leakage of electrons from ubiquinone in mitochondrial electron transport, and perhaps by peroxisomal oxidation of urate. Our results are consistent with the view that heat shock causes oxidative stress, which in turn induces heat shock proteins and production of reduced oxygen metabolites.

Download Full-text

Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation

Autoimmune Diseases ◽

10.1155/2012/836519 ◽

2012 ◽

Vol 2012 ◽

pp. 1-13 ◽

Cited By ~ 9

Author(s):

Earl G. Noble ◽

Garry X. Shen

Keyword(s):

Oxidative Stress ◽

Heat Shock ◽

Heat Shock Proteins ◽

Inflammatory Mediators ◽

Metabolic Disorders ◽

Cell Injury ◽

Vascular Inflammation ◽

Atherosclerotic Cardiovascular Disease ◽

Heat Shock Factor 1 ◽

Shock Proteins

Heat shock proteins (Hsp) play critical roles in the body’s self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular proteins. Exercise increases the levels of Hsp through elevated temperature, hormones, calcium fluxes, reactive oxygen species (ROS), or mechanical deformation of tissues. Isotonic contractions and endurance- type activities tend to increase Hsp60 and Hsp70. Eccentric muscle contractions lead to phosphorylation and translocation of Hsp25/27. Exercise-induced transient increases of Hsp inhibit the generation of inflammatory mediators and vascular inflammation. Metabolic disorders (hyperglycemia and dyslipidemia) are associated with type 1 diabetes (an autoimmune disease), type 2 diabetes (the common type of diabetes usually associated with obesity), and atherosclerotic cardiovascular disease. Metabolic disorders activate HSF/Hsp pathway, which was associated with oxidative stress, increased generation of inflammatory mediators, vascular inflammation, and cell injury. Knock down of heat shock factor-1 (HSF1) reduced the activation of key inflammatory mediators in vascular cells. Accumulating lines of evidence suggest that the activation of HSF/Hsp induced by exercise or metabolic disorders may play a dual role in inflammation. The benefits of exercise on inflammation and metabolism depend on the type, intensity, and duration of physical activity.

Download Full-text

Copper and arsenic-induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines

International Immunopharmacology ◽

10.1016/j.intimp.2018.04.038 ◽

2018 ◽

Vol 60 ◽

pp. 64-75 ◽

Cited By ~ 46

Author(s):

Yu Wang ◽

Hongjing Zhao ◽

Juanjuan Liu ◽

Yizhi Shao ◽

Jinglun Li ◽

...

Keyword(s):

Oxidative Stress ◽

Heat Shock ◽

Heat Shock Proteins ◽

Immune Imbalance ◽

Shock Proteins

Download Full-text

The Effects of Sesquiterpenes-Rich Extract ofAlpinia oxyphyllaMiq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice

Oxidative Medicine and Cellular Longevity ◽

10.1155/2014/451802 ◽

2014 ◽

Vol 2014 ◽

pp. 1-11 ◽

Cited By ~ 21

Author(s):

Shao-Huai Shi ◽

Xu Zhao ◽

Bing Liu ◽

Huan Li ◽

Ai-Jing Liu ◽

...

Keyword(s):

Oxidative Stress ◽

Amyloid Β ◽

Clinical History ◽

Memory Deficits ◽

Term Treatment ◽

Neuroprotective Activity ◽

Nuclear Condensation ◽

Alpinia Oxyphylla ◽

Long Term Treatment

As a kind of medicine which can also be used as food,Alpinia oxyphyllaMiq. has a long clinical history in China. A variety of studies demonstrated the significant neuroprotective activity effects of chloroform (CF) extract from the fruits ofAlpinia oxyphylla.In order to further elucidate the possible mechanisms of CF extract which mainly contains sesquiterpenes with neuroprotection on the cognitive ability, mice were injected with Aβ1−42and later with CF in this study. The results showed that the long-term treatment of CF enhanced the cognitive performances in behavior tests, increased activities of glutathione peroxidase (GSH-px) and decreased the level of malondialdehyde (MDA), acetylcholinesterase (AChE), and amyloid-β(Aβ), and reversed the activation of microglia, degeneration of neuronal acidophilia, and nuclear condensation in the cortex and hippocampus. These results demonstrate that CF ameliorates learning and memory deficits by attenuating oxidative stress and regulating the activation of microglia and degeneration of neuronal acidophilia to reinforce cholinergic functions.

Download Full-text

Alteration of the protein synthesis pattern in Neurospora crassa cells by hyperthermal and oxidative stress

Canadian Journal of Microbiology ◽

10.1139/m87-028 ◽

1987 ◽

Vol 33 (2) ◽

pp. 162-168 ◽

Cited By ~ 22

Author(s):

M. Kapoor ◽

J. Lewis

Keyword(s):

Oxidative Stress ◽

Heat Shock ◽

Heat Shock Proteins ◽

Neurospora Crassa ◽

Sodium Arsenite ◽

Dna Binding Protein ◽

Specific Protein ◽

One Dimensional ◽

Shock Proteins ◽

And Oxidative Stress

Neurospora crassa cells, grown at 28 °C for 14 h and heat shocked at 48 °C for 45 min, showed the synthesis of 11 heat-shock proteins (nHSPs) in one-dimensional electrophoretic profiles. Treatment with sodium arsenite induced the synthesis of two heat-shock proteins, nHSP70 and nHSP80, and a third, arsenite-specific protein, not induced by hyperthermia. Exposure to 0.5 or 1.0 mM H2O2 led to the induction of two of the heat-inducible nHSP70 family polypeptides. Sodium selenite, used in concert with H2O2, and arsenite were observed to modulate that heat-shock response. In addition, H2O2, menadione, and the glutathione depleters diamide and diethyl maleate promoted the synthesis of another protein, designated oxidative stress-responsive protein (OSP). A DNA-binding protein, specific for Neurospora DNA, was also demonstrated in extracts of heat-shocked cells.

Download Full-text