Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides

Peptides ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1255-1261 ◽  
Author(s):  
Jun Yang ◽  
Jin-Ying Liang ◽  
Peng Li ◽  
Yan-Juan Pan ◽  
Pei-Yong Qiu ◽  
...  
Keyword(s):  
Periaqueductal Gray ◽  
Pain Modulation ◽  
Endogenous Opiate ◽  
Opiate Peptides

scholarly journals Acetylcholine participates in pain modulation by influencing endogenous opiate peptides in rat spinal cord

2012 ◽  
Vol 02 (01) ◽  
pp. 15-22 ◽  
Author(s):  
Jun Yang ◽  
Ying Zhao ◽  
Yanjuan Pan ◽  
Guangzhou Lu ◽  
Lu Lu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Pain Modulation ◽  
Rat Spinal Cord ◽  
Endogenous Opiate ◽  
Opiate Peptides

scholarly journals Serotonin Influences the Endogenous Opiate Peptides in the Rat Spinal Cord to Participates in Pain Modulation

2012 ◽  
Vol 02 (02) ◽  
pp. 29-35
Author(s):  
Yan-Juan Pan ◽  
Zhi-Kui Yin ◽  
Jun Yang ◽  
Ying Zhao ◽  
Da-Xin Wang
Keyword(s):  
Spinal Cord ◽  
Pain Modulation ◽  
Rat Spinal Cord ◽  
Endogenous Opiate ◽  
Opiate Peptides

The periaqueductal gray and descending pain modulation: why should we study them and what role do they play in chronic pain?

2015 ◽  
Vol 114 (4) ◽  
pp. 2080-2083 ◽  
Author(s):  
Kasey S. Hemington ◽  
Marie-Andrée Coulombe
Keyword(s):  
Chronic Pain ◽  
Back Pain ◽  
Functional Connectivity ◽  
Recent Literature ◽  
Chronic Back Pain ◽  
Periaqueductal Gray ◽  
Pain Modulation ◽  
Pain Research ◽  
Descending Pain Modulation ◽  
Pain Patients

In this Neuro Forum we discuss the significance of a recent study by Yu et al. ( Neuroimage Clin 6: 100–108, 2014). The authors examined functional connectivity of a key node of the descending pain modulation pathway, the periaqueductal gray (PAG), in chronic back pain patients. Altered PAG connectivity to pain-related regions was found; we place results within the context of recent literature and emphasize the importance of understanding the descending component of pain in pain research.

scholarly journals The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females: Are the Anatomy and Physiology Really that Different?

2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Dayna R. Loyd ◽  
Anne Z. Murphy
Keyword(s):  
Spinal Cord ◽  
Periaqueductal Gray ◽  
Pain Modulation ◽  
Spinal Cord Dorsal Horn ◽  
Implicit Assumption ◽  
Anatomy And Physiology ◽  
Wide Range ◽  
Ventromedial Medulla ◽  
Spinal Cord Dorsal ◽  
The 1960S

Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray (PAG) and its descending projections to the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, as a primary anatomical pathway mediating opioid-based analgesia. Since these initial studies, the PAG-RVM-spinal cord pathway has been characterized anatomically and physiologically in a wide range of vertebrate species. Remarkably, the majority of these studies were conducted exclusively in males with the implicit assumption that the anatomy and physiology of this circuit were the same in females; however, this is not the case. It is well established that morphine administration produces greater antinociception in males compared to females. Recent studies indicate that the PAG-RVM pathway contributes to the sexually dimorphic actions of morphine. This manuscript will review our anatomical, physiological, and behavioral data identifying sex differences in the PAG-RVM pathway, focusing on its role in pain modulation and morphine analgesia.

scholarly journals Endogenous opiate peptides, stress reactivity, and risk for hypertension.

Hypertension ◽  
1985 ◽  
Vol 7 (5) ◽  
pp. 808-811 ◽  
Author(s):  
J A McCubbin ◽  
R S Surwit ◽  
R B Williams
Keyword(s):  
Stress Reactivity ◽  
Endogenous Opiate ◽  
Opiate Peptides

scholarly journals Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jin Cao ◽  
Yue Zhang ◽  
Hui Li ◽  
Zhaoxian Yan ◽  
Xian Liu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Resting State ◽  
Vagus Nerve Stimulation ◽  
Cingulate Cortex ◽  
Periaqueductal Gray ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Descending Pain Modulation

Abstract Background A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study is to investigate the modulation effect of taVNS frequency on the descending pain modulation system (DPMS) in patients with migraine. Methods Twenty-four episodic migraineurs without aura (21 females) were recruited for the single-blind, crossover, functional magnetic resonance imaging (fMRI) study. Each participant attended two separate fMRI scan sessions, one for 1 Hz and another for 20 Hz taVNS, in a random order. Seed-based functional connectivity analysis was applied using the ventrolateral periaqueductal gray (PAG) as the region of interest. Results Compared with the pre-taVNS resting state, continuous 1 Hz taVNS (during) produced a significant increase in functional connectivity between the PAG and the bilateral middle cingulate cortex (MCC), right precuneus, left middle frontal gyrus (MFG), and left cuneus. Compared with 20 Hz taVNS, 1 Hz taVNS produced greater PAG connectivity increases with the MCC, right precuneus/posterior cingulate cortex, left insula, and anterior cingulate cortex (ACC). A significant negative correlation was observed between the number of migraine attacks in the previous 4 weeks and the PAG-MCC functional connectivity in the pre-taVNS resting-state before 1 Hz taVNS. Conclusions Our findings suggest that taVNS with different frequencies may produce different modulation effects on the descending pain modulation system, demonstrating the important role of stimulation frequency in taVNS treatment.

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