scholarly journals Study of bone mineral metabolism in children with acute lymphoblastic leukemia

2017 ◽  
Vol 2 (2) ◽  
pp. S14
Author(s):  
Shalini Dash ◽  
Rimjhim Sonowal ◽  
S.K. Singh ◽  
Vineeta Gupta
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Lymphoblastic Leukemia ◽  
Bone Mineral Metabolism

scholarly journals Alteration in Bone Mineral Metabolism in Children with Acute Lymphoblastic Leukemia (ALL): A Review

2009 ◽  
Vol 1 (1) ◽  
pp. 29
Author(s):  
Chowdhury Yakub Jamal
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Mineral ◽  
Late Effects ◽  
Mineral Metabolism ◽  
Lymphoblastic Leukemia ◽  
Prostaglandin E ◽  
Mineral Density ◽  
Metabolic Alterations ◽  
Bone Mineral Metabolism ◽  
Pediatric Cancer Patients

<p>In recent years there has been a significant increase in event free survival (EFS) and overall survival in children with cancer. As survival rates for childhood cancer have radically improved, late effects associated with the successful but highly intensive chemotherapy and/or radiotherapy have dramatically increased. Many possible late effects of cancer treatment are recognized in pediatric cancer patients as infertility, endocrine deficiency, renal failure, pulmonary and cardiac toxicity, obesity and osteopenia/osteoporosis. Decreased bone mineral density (BMD) and bone metabolism disturbances have been recognized and reported in literature. Osteopenia/osteoporosis skeletal abnormalities, osteonecrosis and pathological fractures are known to occur frequently in childhood acute lymphoblastic leukemia (ALL) at diagnosis, during and after treatment with chemotherapy. Various studies have revealed different metabolic alterations related to ALL. Some suggestions have been made about their relationship with the disease process. Various metabolic abnormalities may be encountered in the newly diagnosed ALL patients. It includes decreased and increased serum levels of calcium and phosphate. Hypercalcemia may result from leukemic infiltrations of bone and release of parathormone like substance from lymphoblast. Elevated serum phosphate can occur as a result of leukemic cell lysis and may induce hypocalcemia. It has been postulated by other authors that leukemic cells may directly infiltrate bone and produce parathroid hormone related peptides, prostaglandin E and osteoblast inhibiting factors. Hypomagnesemia, hypocalcaemia and hypothyroidisum have been demonstrated in patients with ALL. Some patients may have poor nutrition and decreased physical activities during treatment. However postulations have also been made that chemotherapy may play a role in creating metabolic alterations in children with ALL. Corticosteroid, methotraxate and cranial irradiations have all been assumed as a cause of loss of bone mass. Continuing chemotherapy in children with ALL was assumed with normal growth and normal or high collagen turnover and reduced alkaline phosphatase or impaired osteoblastic activity on mineralization of bone. Considering the derangements in bone mineral metabolism in ALL at diagnosis or with chemotherapy, it is imperative that specific attention and therapeutic measures should be considered.</p><p>DOI: 10.3329/bsmmuj.v1i1.3695</p> <p><em>BSMMU J </em>2008; 1(1): 29-32</p>

Bone mass and bone mineral metabolism at diagnosis and after intensive treatment in children with acute lymphoblastic leukemia

2003 ◽  
Vol 41 (6) ◽  
pp. 578-580 ◽  
Author(s):  
Violetta ?wi?tkiewicz ◽  
Mariusz Wysocki ◽  
Gra?yna Odrow??-Sypniewska ◽  
Andrzej Koltan ◽  
Slawomir Manysiak ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Mass ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Lymphoblastic Leukemia ◽  
Intensive Treatment ◽  
Bone Mineral Metabolism

Bone Mineral Metabolism During Chemotherapy in Childhood Acute Lymphoblastic Leukemia

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Sonal Maddheshiya ◽  
Surya K. Singh ◽  
Ishan Kumar ◽  
Priyanka Aggarwal ◽  
Vineeta Gupta
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Bone Mineral Metabolism

scholarly journals The proportion of bone mineral density in children with high risk acute lymphoblastic leukemia after 6- and 12-month chemotherapy maintenance phase

2016 ◽  
Vol 50 (6) ◽  
pp. 365
Author(s):  
Mira Christiyani Santoso ◽  
Endang Windiastuti ◽  
Alan R. Tumbelaka
Keyword(s):  
Bone Mineral Density ◽  
Acute Lymphoblastic Leukemia ◽  
High Risk ◽  
Bone Mineral ◽  
Calcium Ion ◽  
Mineral Metabolism ◽  
Lymphoblastic Leukemia ◽  
Maintenance Phase ◽  
Z Score ◽  
Mineral Density

Background Low bone mineral density (BMD) value is one of the current concerns in acute lymphoblastic leukemia (ALL) patients. Some risk factors including use of chemotherapeutic drugs, nutritional status, phy sical activities, and progression of disease are suspected as the predisposing factors for development of osteopenia and osteoporosis.Objectives To obtain the proportion of BMD z-score, level of calcium ions, and 25 (OH)D3 in children 'With high risk ALL after 6 and 12 months chemotherapy maintenance phase.Methods We conducted a cross-sectional comparative study from May 2008 to May 2010. Subjects were high risk ALL patients aged 5-18 years old who had completed the 6 or 12 months chemotherapy maintenance phase. We measured 25 (OH) D3 level, calcium ion level, and BMD using electro chemi-luminescence immunoassay, ion selective electrode, and dual x-ray absorptiometry, respectively.Results There were 40 subjects who enrolled this study. The incidence of hypocalcemia and vitamin D deficiency were 33/40 and 40/40, respectively. The mean calcium ion levels, 25 (OH)D3 level, and BMD z􀁏score values in six months groups were 1.1 (0.1 SD) mmol/L, 21.3 (2 SD) ng/L, -0.7 (0.8 SD), respectively, while in the 12 months group, the values were 1.1 (0.0 SD) mmol/L, 21(2.2 SD) ng/L, -1.7 (0.6 SD), respectively (P=0.478). Body mass index (BMI) and corticosteroid cumulative dose is correlated \\lith the low BMD values in L1-L4.Conclusion The bone mineral metabolism disorder marked with the low levels of calcium, 25 (OH)D3 and osteopenia was observed in ALL patients who underwent chemotherapy. The proportion of the BMD z-score value, calcium ion level, and 25 (OH) D3 in the two groups were not statistically significant.

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