Global stability and Hopf bifurcation of a generalized viral infection model with multi-delays and humoral immunity

2020 ◽  
Vol 545 ◽  
pp. 123689 ◽  
Author(s):  
Khalid Hattaf
Keyword(s):  
Hopf Bifurcation ◽  
Viral Infection ◽  
Global Stability ◽  
Humoral Immunity ◽  
Infection Model ◽  
Viral Infection Model

scholarly journals A Fractional Order Model for Viral Infection with Cure of Infected Cells and Humoral Immunity

2018 ◽  
Vol 2018 ◽  
pp. 1-12
Author(s):  
Adnane Boukhouima ◽  
Khalid Hattaf ◽  
Noura Yousfi
Keyword(s):  
Viral Infection ◽  
Humoral Immunity ◽  
Host Cells ◽  
Infection Model ◽  
Order Model ◽  
Fractional Order Model ◽  
Infected Cells ◽  
Fractional Differential ◽  
Well Posed ◽  
Viral Infection Model

In this paper, we study the dynamics of a viral infection model formulated by five fractional differential equations (FDEs) to describe the interactions between host cells, virus, and humoral immunity presented by antibodies. The infection transmission process is modeled by Hattaf-Yousfi functional response which covers several forms of incidence rate existing in the literature. We first show that the model is mathematically and biologically well-posed. By constructing suitable Lyapunov functionals, the global stability of equilibria is established and characterized by two threshold parameters. Finally, some numerical simulations are presented to illustrate our theoretical analysis.

Global Stability and Hopf Bifurcation in a Delayed Viral Infection Model with Cell-to-Cell Transmission and Humoral Immune Response

2019 ◽  
Vol 29 (12) ◽  
pp. 1950161 ◽  
Author(s):  
Jinhu Xu ◽  
Yan Geng ◽  
Suxia Zhang
Keyword(s):  
Immune Response ◽  
Hopf Bifurcation ◽  
Viral Infection ◽  
Humoral Immune Response ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Humoral Immune ◽  
Cell Transmission ◽  
Viral Infection Model ◽  
Intracellular Delays

We have developed a class of viral infection model with cell-to-cell transmission and humoral immune response. The model addresses both immune and intracellular delays. We also constructed Lyapunov functionals to establish the global dynamical properties of the equilibria. Theoretical results indicate that considering only two intracellular delays did not affect the dynamical behavior of the model, but incorporating an immune delay greatly affects the dynamics, i.e. an immune delay may destabilize the immunity-activated equilibrium and lead to Hopf bifurcation, oscillations and stability switches. Our results imply that an immune delay dominates the intracellular delays in the model. We also investigated the direction of the Hopf bifurcation and the stability of the periodic solutions by applying normal form and center manifold theory, and investigated the existence of global Hopf bifurcation by regarding the immune delay as a bifurcation parameter. Numerical simulations are carried out to support the analytical conclusions.

scholarly journals Global Stability for a Viral Infection Model with Saturated Incidence Rate

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Huaqin Peng ◽  
Zhiming Guo
Keyword(s):  
Viral Infection ◽  
Global Stability ◽  
Incidence Rate ◽  
Sufficient Conditions ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infection Model ◽  
Saturated Incidence Rate ◽  
Saturated Incidence ◽  
Viral Infection Model

A viral infection model with saturated incidence rate and viral infection with delay is derived and analyzed; the incidence rate is assumed to be a specific nonlinear formβxv/(1+αv). The existence and uniqueness of equilibrium are proved. The basic reproductive numberR0is given. The model is divided into two cases: with or without delay. In each case, by constructing Lyapunov functionals, necessary and sufficient conditions are given to ensure the global stability of the models.

Dynamical behaviors of a general humoral immunity viral infection model with distributed invasion and production

2017 ◽  
Vol 10 (03) ◽  
pp. 1750035 ◽  
Author(s):  
A. M. Ełaiw ◽  
N. H. AlShamrani ◽  
K. Hattaf
Keyword(s):  
Viral Infection ◽  
Humoral Immunity ◽  
Lyapunov Functions ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Global Dynamics ◽  
Nonlinear Mathematical Model ◽  
Dynamical Behaviors ◽  
Number Formula ◽  
Viral Infection Model

A general nonlinear mathematical model for the viral infection with humoral immunity and two distributed delays is proposed and analyzed. Two bifurcation parameters, the basic reproduction number, [Formula: see text] and the humoral immunity number, [Formula: see text] are derived. We established a set of conditions on the general functions which are sufficient to determine the global dynamics of the model. Utilizing Lyapunov functions and LaSalle’s invariance principle, the global asymptotic stability of all equilibria of the model is obtained. An example is presented and some numerical simulations are conducted in order to illustrate the dynamical behavior.

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