Injury to the peripheral nerve affects the whole length of the neuron and is not just localized to the site of injury, making a nerve injury different from other types of tissue injury in the body. Moreover, a nerve injury has immediate functional consequences for the brain in terms of rapid cortical functional reorganization. Lifelong limitations of hand function with loss of sensibility, muscle weakness, prehensile problems, pain, and cold sensitivity are common. Recovery can take years in adults, especially of tactile discrimination, but often remains incomplete and quality of life may be significantly affected. Numerous factors influence the outcome: age, type of injury, timing of surgery, and cognitive capacity. In addition, education, sex, and post-traumatic stress have proved to be prognostic factors. The timing of hand rehabilitation including sensory and motor re-education are also important contributors to the final outcome.