Evidence of altitudinal gradient modifying genomic and chemical diversity in populations of Lychnophora pinaster Mart.

2021 ◽  
Vol 192 ◽  
pp. 112898
Author(s):  
Roberto O. Portella ◽  
Erick M.G. Cordeiro ◽  
Ana Paula S. Marques ◽  
Lin C. Ming ◽  
Maria I. Zucchi ◽  
...  
Keyword(s):  
Altitudinal Gradient ◽  
Chemical Diversity

Influence of Chemical Diversity in Determining Lichen Communities Structure along an Altitudinal Gradient in the Chopta Tungnath, Western Himalaya

2017 ◽  
Vol 3 (01) ◽  
pp. 07-13
Author(s):  
Vertika Shukla ◽  
Rajesh Bajpai ◽  
Manoj Semwal ◽  
D. K. Upreti
Keyword(s):  
Species Diversity ◽  
Secondary Metabolites ◽  
Species Composition ◽  
Altitudinal Gradient ◽  
Western Himalaya ◽  
Chemical Diversity ◽  
Lichen Diversity ◽  
Lichen Community ◽  
High Precipitation

In recent years there has been growing interest in the study on lichen diversity with relation to altitudinal gradient and anthropogenic disturbances , as changes in lichen community composition may indicate air quality and microclimatic changes. The altitudinal data of species diversity and its subsequent changes with respect to time and space may provide vital information regarding impact of air pollution and/or climate change at regional or global scales. Chopta-Tungnath and adjoining areas of Garhwal Himalaya provide habitat and ecological variation with range of altitude lying between 300 to 3000 m. Out of the 116 species of lichens known from the studied area, the highest species diversity was observed between altitudes 1800 to 2100 m. Lichen communities occurring between 600–1800 m were dominated by members of Physciaceae, while Parmeliaceae were most common above 1800 m. Altitude beyond 2100 m experiences high precipitation, varying temperature conditions and increased incident UV radiation, which are responsible for controlling the variability in lichen diversity to a great extent in the region. The diversity of secondary metabolites in lichen species and consequent changes in species composition at various altitudes indicate the association of secondary chemicals in conferring the lichens resistance to biotic and abiotic stresses. The correlations of lichen diversity, secondary metabolites and the altitudes at which the lichens are growing, present suggestive role of secondary metabolites in determining species composition and sustainability in different environmental conditions.

What can phylogeny tell us about chemical diversity?

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
N Rønsted ◽  
GI Stafford ◽  
AW Meerow ◽  
G Petersen ◽  
J Van Staden ◽  
...  
Keyword(s):  
Chemical Diversity

High throughput screening to investigate Brazilian Cerrado biome plant extract bank chemical diversity

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LS Espindola ◽  
RG Dusi ◽  
KR Gustafson ◽  
J McMahon ◽  
JA Beutler
Keyword(s):  
High Throughput ◽  
Plant Extract ◽  
High Throughput Screening ◽  
Chemical Diversity ◽  
Brazilian Cerrado ◽  
Cerrado Biome

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain

2020 ◽  
Author(s):  
Luke Adams ◽  
Lorna E. Wilkinson-White ◽  
Menachem J. Gunzburg ◽  
Stephen J. Headey ◽  
Martin J. Scanlon ◽  
...  
Keyword(s):  
Binding Site ◽  
Systematic Approach ◽  
Structural Information ◽  
Peptide Binding ◽  
Chemical Diversity ◽  
Chemical Probes ◽  
Protein Targets ◽  
Structure Activity ◽  
Peptide Binding Site ◽  
Selection Of

The development of low-affinity fragment hits into higher affinity leads is a major hurdle in fragment-based drug design. Here we demonstrate an approach for the Rapid Elaboration of Fragments into Leads (REFiL) applying an integrated workflow that provides a systematic approach to generate higher-affinity binders without the need for structural information. The workflow involves the selection of commercial analogues of fragment hits to generate preliminary structure-activity relationships. This is followed by parallel microscale chemistry using chemoinformatically designed reagent libraries to rapidly explore chemical diversity. Upon completion of a fragment screen against Bromodomain-3 extra terminal (BRD3-ET) domain we applied the REFiL workflow, which allowed us to develop a series of tetrahydrocarbazole ligands that bind to the peptide binding site of BRD3-ET. With REFiL we were able to rapidly improve binding affinity >30-fold. The REFiL workflow can be applied readily to a broad range of protein targets without the need of a structure, allowing the efficient evolution of low-affinity fragments into higher affinity leads and chemical probes.<br>

Oxazole-Based Compounds As Anticancer Agents

2020 ◽  
Vol 26 (41) ◽  
pp. 7337-7371 ◽  
Author(s):  
Maria A. Chiacchio ◽  
Giuseppe Lanza ◽  
Ugo Chiacchio ◽  
Salvatore V. Giofrè ◽  
Roberto Romeo ◽  
...  
Keyword(s):  
Cancer Research ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Chemical Diversity ◽  
Biologically Active ◽  
New Drugs ◽  
The Core ◽  
Anti Cancer ◽  
Biologically Active Derivatives

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

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