Association of subjective health and abnormal cervical cytology in Japanese pregnant women: an adjunct study of the Japan Environment and Children's Study

Background: This study aimed to know the prevalence of abnormal cervical cytology in pregnant women by liquid-based cytology (LBC). Materials and Methods : Cross sectional study done at a tertiary care hospital in between August 2017 to January 2019.Six hundred pregnant women attending the OPD at their rst visit were enrolled and after taking consent, history and clinical examination , subjected to cervical cancer screening by LBC. Result: Out of 600 samples, 10 samples (1.67%) were unsatisfactory for evaluation due to low cellularity. Among 590 samples, only 2 reported as LSIL(Low grade squamous intraepithelial lesion) and 588 reported as NILM (Negative for intraepithelial lesion or malignancy). Inammation of varying degree, mild, moderate and dense was reported in 58.65%, 24.92% and 16.44% respectively. Infection was reported in 3.73% and Candida. Discussion: prevalence of abnormal cervical cytology among pregnant women in region was low but screening for cancer cervix should be done for all pregnant women, adverse pregnancy outcomes like premature rupture of membranes, preterm birth and low birth weight.

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A study of abnormal cervical cytology in pregnant women

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-005-0032-z ◽

2005 ◽

Vol 273 (5) ◽

pp. 274-277 ◽

Cited By ~ 1

Author(s):

Tatsuo Yamazaki ◽

Fujiyuki Inaba ◽

Nobuhiko Takeda ◽

Makiko Huruno ◽

Tetsu Kamemori ◽

...

Keyword(s):

Pregnant Women ◽

Cervical Cytology ◽

Abnormal Cervical Cytology

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Management of pregnant women with abnormal cervical cytology.

The Journal of the Japanese Society of Clinical Cytology ◽

10.5795/jjscc.33.474 ◽

1994 ◽

Vol 33 (3) ◽

pp. 474-478

Author(s):

Kenji ISHII ◽

Kazuya KUDO ◽

Yoshihiro KIKUCHI ◽

Ichiro NAGATA ◽

Mikio ANZAI ◽

...

Keyword(s):

Pregnant Women ◽

Cervical Cytology ◽

Abnormal Cervical Cytology

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A study of abnormal cervical cytology in pregnant women

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-005-0063-5 ◽

2005 ◽

Vol 273 (6) ◽

pp. 355-359

Author(s):

Tatsuo Yamazaki ◽

Fujiyuki Inaba ◽

Nobuhiko Takeda ◽

Makiko Furuno ◽

Tetsu Kamemori ◽

...

Keyword(s):

Pregnant Women ◽

Cervical Cytology ◽

Abnormal Cervical Cytology

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Concentration of folic acid (FA) in serum of Japanese pregnant women

Reviews on Environmental Health ◽

10.1515/reveh-2020-0014 ◽

2020 ◽

Vol 35 (3) ◽

pp. 277-280

Author(s):

Nathan Mise ◽

Mayumi Ohtsu ◽

Akihiko Ikegami ◽

Yoko Hosoi ◽

Yoshihiko Nakagi ◽

...

Keyword(s):

Folic Acid ◽

Pregnant Women ◽

Epigenetic Modification ◽

Large Fraction ◽

Body Burden ◽

Inorganic Arsenic ◽

Health Concern ◽

Japanese Children ◽

Cross Sectional ◽

Japanese Pregnant Women

AbstractObjectivesExposure to inorganic arsenic (iAs) is a world-wide health concern. We reported that Japanese children and pregnant women are exposed to moderate levels of iAs through food. Reducing iAs contamination from foods of high iAs is an important issue unique in Japan. Integrated iAs is methylated to less toxic organic forms, and S-adenosyl-L-methyonine (SAM), a common methyl-donor of DNA and histones, is utilized in this process. Chronic consumption of SAM by iAs metabolism due to exposure to iAs might alter the epigenetic modification of genome. The SAM biosynthesis pathway is dependent on folate cycle, and it is possible that ingestion of sufficient folic acid (FA) is protective to iAs induced toxicity.MethodsIn the course of our cross-sectional body burden analyses of Pb and iAs in Japanese children and pregnant women, termed “PbAs study”, FA concentration in serum of 104 pregnant women was measured.ResultsMean (±SEM) of serum FA concentration was 15.8 ± 1.3 (ng/mL). There are significant number of people showing very high FA (>30 ng/ mL), and large fraction of them were taking supplements daily.ConclusionsThese results suggested that level of FA ingestion of Japanese pregnant women is high for supporting normal fetal development.

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DNA ploidy measurement and human papillomavirus in abnormal cervical cytology

Cytopathology ◽

10.1111/cyt.12943 ◽

2020 ◽

Author(s):

Ane Francyne Costa ◽

Adriane Pogere ◽

Ana Paula Beltrame Farina Pasinato ◽

Edson Jose Monteiro Bello ◽

Alexandre Sherlley Casimiro Onofre ◽

...

Keyword(s):

Human Papillomavirus ◽

Dna Ploidy ◽

Cervical Cytology ◽

Abnormal Cervical Cytology

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Cervical cytologic abnormalities and negative colposcopy: histologic assessment

International Journal of Gynecological Cancer ◽

10.1046/j.1525-1438.1994.04050348.x ◽

1994 ◽

Vol 4 (5) ◽

pp. 348-351 ◽

Cited By ~ 4

Author(s):

R. Chenoy ◽

S. Manohar ◽

C. W.E. Redman ◽

D. M. Luesley

Keyword(s):

Cervical Cytology ◽

Histologic Diagnosis ◽

Abnormal Cervical Cytology ◽

Accurate Definition ◽

Cone Biopsy ◽

Histologic Evaluation ◽

Simple Regression Analysis ◽

Definition Of ◽

Cytologic Abnormalities ◽

Intraepithelial Lesions

Colposcopic assessment may be normal in the presence of severe or persistent minor cytologic abnormality. To assess the significance of negative satisfactory colposcopy in patients with abnormal cervical smears, a retrospective review was carried out on 1170 patients who had undergone out-patient loop diathermy excision for abnormal cervical cytology. Of these, 69 patients were treated for abnormal cervical cytology, despite normal colposcopic findings. Cytologic abnormalities ranged from persistent borderline changes to severe dyskariosis. Histologic assessment of the excision specimens revealed cervical intraepithalial neoplasia (CIN) in 43 (62.3%) cases, of which high-grade CIN accounted for 24 (34.8%) cases. There was good correlation between cytologic and histologic diagnosis. Simple regression analysis showedr= 0.46,P< 0.0001. The cytologic abnormality was highly predictive of the corresponding histologic diagnosis. This analysis has shown that significant intraepithelial lesions may exist despite negative colposcopic examination and highlights the need for histologic evaluation in such cases. In these circumstances, loop cone biopsy permits accurate definition of lesion severity, avoids potential undertreatment of significant lesions and causes less morbidity than conventional cone biopsy.

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