Poster 116 Association of Serum Brain-Derived Neurotrophic Factor with Functional Independence Measure after Ischemic Stroke

PM&R ◽  
2015 ◽  
Vol 7 ◽  
pp. S129-S130
Author(s):  
Fenghua Zhou ◽  
Shanshan Li ◽  
Xun Luo ◽  
Qing M. Wang
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Functional Independence Measure ◽  
Brain Derived Neurotrophic Factor ◽  
Functional Independence

scholarly journals Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI

2015 ◽  
Vol 30 (5) ◽  
pp. 419-430 ◽  
Author(s):  
Michelle D. Failla ◽  
Shannon B. Juengst ◽  
Patricia M. Arenth ◽  
Amy K. Wagner
Keyword(s):  
Cognitive Impairment ◽  
Neurotrophic Factor ◽  
Functional Independence Measure ◽  
Brain Derived Neurotrophic Factor ◽  
Functional Independence ◽  
Hippocampal Damage ◽  
Patient Health ◽  
Severe Tbi ◽  
With Memory ◽  
Serum Bdnf

Background. Traumatic brain injury (TBI) often leads to mood and cognitive complications, affecting functional recovery. Understanding neurobiological alterations common in post-TBI depression (PTD) and cognition may identify novel biomarkers for TBI complications. Brain-derived neurotrophic factor (BDNF) is a likely target based on evidence of reduced BDNF signaling in experimental TBI and depression models and its role in learning and memory. Objective. To evaluate BDNF as a biomarker for PTD, cognitive impairment, and functional cognition in a prospective cohort with severe TBI. Methods. Participants with TBI (n = 113) were evaluated for PTD (Patient Health Questionnaire-9 [PHQ-9]), cognitive impairment (cognitive composite score), and functional cognition (Functional Independence Measure–Cognition, FIM-Cog). BDNF levels were measured in cerebrospinal fluid and serum at 0 to 6 days postinjury and in serum at 6 and 12 months postinjury. Results. Serum BDNF was reduced after TBI versus controls at all time points. Acute serum BDNF positively correlated with memory composites (6 months: r = 0.43, P = .019, n = 30; 12 months: r = 0.53, P = .005, n = 26) and FIM-Memory scores (6 months: r = 0.35, P = .019, n = 45; 12 months: r = 0.38, P = .018, n = 38). Acute serum BDNF negatively correlated with 12-month PHQ-9 scores ( r = −0.38; P = .044; n = 29). At 12 months, chronic serum BDNF tended to be lower in participants with PTD ( P = .07) and correlated with PHQ-9 scores ( r = −0.41; P = .019; n = 32). Conclusions. Acute BDNF associations with memory recovery may implicate hippocampal damage/degeneration. Comparatively, BDNF associations with PTD status were not as strong as associations with PTD severity. Further investigation may delineate longitudinal BDNF patterns, and BDNF responsive treatments, reflecting mood and cognitive recovery following TBI.

Aerobic exercises enhance cognitive functions and brain derived neurotrophic factor in ischemic stroke patients

2014 ◽  
Vol 34 (1) ◽  
pp. 209-213 ◽  
Author(s):  
Mohamed S. El-Tamawy ◽  
Foad Abd-Allah ◽  
Sandra M. Ahmed ◽  
Moshera H. Darwish ◽  
Heba A. Khalifa
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Functions ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Patients

scholarly journals Higher Blood Glucose within the Normal Range Is Associated with More Severe Strokes

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Rolf J. Martin ◽  
Rajiv R. Ratan ◽  
Michael J. Reding ◽  
Tom S. Olsen
Keyword(s):  
Ischemic Stroke ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Vital Signs ◽  
Functional Independence Measure ◽  
Multiple Linear Regression Model ◽  
Functional Independence ◽  
Stroke Severity ◽  
Severe Stroke ◽  
Average Decrease

Background. Higher fasting blood glucose (FBG) concentrations in the hyperglycemic range are associated with more severe strokes. Whether this association also extends into patients with FBG in the normoglycemic range is unclear. We studied the association of stroke severity and FBG in normoglycemic patients with ischemic stroke in a median of 7 days after stroke when the initial glycemic stress response has resolved.Method and Material. Included were 361 nondiabetic ischemic stroke patients with admission fasting blood glucose within 70–130 mg/dL admitted into an acute stroke rehabilitation unit in a median of 7 days after stroke. Data including neuroimaging, vital signs, cardiovascular risk factors, and admission functional independence measure (AFIM) were recorded prospectively.Results. FBG correlated with stroke severity in the normoglycemic 70–130 mg/dL range (FBG-AFIM correlation coefficient−0.17;P=0.003). Odds ratio for more severe injury (below average AFIM score) was 2.02 for patients with FBG 110–130 mg/dL compared to FBG 70–90 mg/dL (95% confidence interval 1.10–3.73,P=0.022). Each mg/dL increase in FBG was associated with an average decrease of 0.25 FIM points. In a multiple linear regression model, FBG was associated with more severe stroke (P=0.002).Conclusion. One week after ischemic stroke, FBG within the normoglycemic range was associated with stroke severity.

Brain derived neurotrophic factor profile in children with ischemic stroke

2017 ◽  
Vol 21 ◽  
pp. e172
Author(s):  
Lupusor Nadejda ◽  
Sprincean Mariana ◽  
Revenco Nineli ◽  
Calcii Cornelia ◽  
Hadjiu Svetlana
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Abstract T P127: Look Past the NIHSS! Rehabilitation Metrics that Predict Home Discharge in Ischemic Stroke Patients

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Nneka Ifejika ◽  
Linda Aramburo-Maldonado ◽  
Chunyan Cai ◽  
Melvin R Sline ◽  
Elizabeth A Noser ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Care ◽  
Assisted Living ◽  
Stroke Rehabilitation ◽  
Functional Independence Measure ◽  
Functional Independence ◽  
Advanced Age ◽  
Nursing Facilities ◽  
Stroke Patients ◽  
Home Discharge

Introduction: The goals of stroke rehabilitation are to restore functional ability and to return patients' home with a good quality of life. There is a paucity of data on stroke rehabilitation tools that both track improvements and help predict the likelihood of home discharge. Hypothesis: Improvement in functional independence measure (FIM) score increases home discharge rates, decreases acute care readmissions and decreases placement in skilled nursing facilities (SNF). Advanced age and infections such as symptomatic UTI (SUTI) negate FIM score improvement. Methods: We merged the prospectively collected Stroke and Neurorehabilitation Registries at our comprehensive stroke center, identifying ischemic stroke patients admitted between January 2011 and November 2013 (n=367). Demographics, rehabilitation metrics and NIHSS were collected. Age, SUTI, discharge FIM and rehabilitation length of stay (LOS Rehab) were included in the multivariate regression. Results: Of 367 ischemic stroke patients, 273 went home, 47 to a SNF, 25 to acute care and 22 to another facility (i.e.,assisted living, board and care). All patients tolerated 3 hours of daily therapy (PT, OT, SLP). Despite median NIHSS values of 9 in both groups (P=0.356), patients with SUTI had lower FIM scores on admission (49.2 ± 13.9 vs. 56.8±15.2; P<0.0001) and discharge (68.5 ± 16.9 vs. 76.3 ± 17.0; P<0.0001). For a one year age increase, there was a 5% increase in SNF admit (OR 1.05, 95%CI 1.02-1.08; P<0.001) compared to home. For a one unit increase in FIM, there was a 4% decrease in another facility admit (OR 0.96, 95% CI 0.93 to 0.99; P<0.01), a 6% decrease in SNF admit (OR 0.94, 95%CI 0.92-0.96; P<0.001) and a 10% decrease in acute care readmit (OR 0.90, 95% CI 0.88-0.94; P<0.0001) compared to home. For a one day increase in LOS Rehab, there was a 19% decrease in acute care readmit (OR 0.81, 95% CI 0.73-0.89; P<0.0001) compared to home, and a 7% increase in home discharge compared to another facility (OR 1.07, 95% CI 1.02 to 1.12; P<0.001). Conclusions: Improved FIM score and increased LOS Rehab were the primary criteria for home discharge after stroke rehabilitation. Advanced age increased the likelihood of SNF placement. SUTI impacted rehabilitation progress, but did not affect discharge to home.

scholarly journals Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

2016 ◽  
Vol Volume 10 ◽  
pp. 3545-3553 ◽  
Author(s):  
Tatyana A Gudasheva ◽  
Polina Povarnina ◽  
Ilya O Logvinov ◽  
Tatyana A Antipova ◽  
Sergey B Seredenin
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

2019 ◽  
Vol 28 (3) ◽  
pp. 735-740 ◽  
Author(s):  
Aline Mansueto Mourão ◽  
Laélia Cristina Caseiro Vicente ◽  
Mery Natali Silva Abreu ◽  
Romeu Vale Sant'Anna ◽  
Erica Leandro Marciano Vieira ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Phase ◽  
Neurotrophic Factor ◽  
Plasma Levels ◽  
Brain Derived Neurotrophic Factor

scholarly journals Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

2018 ◽  
Vol 19 (12) ◽  
pp. 3782 ◽  
Author(s):  
Kristine Ravina ◽  
Denise Briggs ◽  
Sezen Kislal ◽  
Zuha Warraich ◽  
Tiffany Nguyen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Recovery ◽  
Neurotrophic Factor ◽  
Infarct Volume ◽  
Brain Derived Neurotrophic Factor ◽  
Artery Occlusion ◽  
Sensorimotor Function ◽  
Neural Repair ◽  
Adhesive Removal ◽  
Cerebral Artery Occlusion

Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived neurotrophic factor (BDNF), delivered via an extended release HyStem®-C hydrogel implant or vehicle, on sensorimotor function, infarct volume, and neuroinflammation, following permanent distal middle cerebral artery occlusion (dMCAo) in rats. Eight days following dMCAo or sham surgery, treatments were implanted directly into the infarction site. Rats received either vehicle, BDNF-only (0.167 µg/µL), hydrogel-only, hydrogel impregnated with 0.057 µg/µL of BDNF (hydrogel + BDNFLOW), or hydrogel impregnated with 0.167 µg/µL of BDNF (hydrogel + BDNFHIGH). The adhesive removal test (ART) and 28-point Neuroscore (28-PN) were used to evaluate sensorimotor function up to two months post-ischemia. The hydrogel + BDNFHIGH group showed significant improvements on the ART six to eight weeks following treatment and their behavioral performance was consistently greater on the 28-PN. Infarct volume was reduced in rats treated with hydrogel + BDNFHIGH as were levels of microglial, phagocyte, and astrocyte marker immunoexpression in the corpus striatum. These data suggest that targeted intracerebral delivery of BDNF using hydrogels may mitigate ischemic brain injury and restore functional deficits by reducing neuroinflammation.

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