O-BN002. Intravenous administration of poly(lactide-co-glycolide) nanoparticle encapsulating brain-derived neurotrophic factor promotes neuroprotection in an ischemic stroke model in the rat

2021 ◽  
Vol 132 (8) ◽  
pp. e77-e78
Author(s):  
Siti Norsyafika Kamarudin ◽  
Igor Iezhitsa ◽  
Minaketan Tripathy ◽  
Renad Alyautdin ◽  
Nafeeza Mohd Ismail
Keyword(s):  
Ischemic Stroke ◽  
Intravenous Administration ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Model

Aerobic exercises enhance cognitive functions and brain derived neurotrophic factor in ischemic stroke patients

2014 ◽  
Vol 34 (1) ◽  
pp. 209-213 ◽  
Author(s):  
Mohamed S. El-Tamawy ◽  
Foad Abd-Allah ◽  
Sandra M. Ahmed ◽  
Moshera H. Darwish ◽  
Heba A. Khalifa
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Functions ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Patients

Brain derived neurotrophic factor profile in children with ischemic stroke

2017 ◽  
Vol 21 ◽  
pp. e172
Author(s):  
Lupusor Nadejda ◽  
Sprincean Mariana ◽  
Revenco Nineli ◽  
Calcii Cornelia ◽  
Hadjiu Svetlana
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Mimetics of brain-derived neurotrophic factor loops 1 and 4 are active in a model of ischemic stroke in rats

2016 ◽  
Vol Volume 10 ◽  
pp. 3545-3553 ◽  
Author(s):  
Tatyana A Gudasheva ◽  
Polina Povarnina ◽  
Ilya O Logvinov ◽  
Tatyana A Antipova ◽  
Sergey B Seredenin
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Plasma Levels of Brain-Derived Neurotrophic Factor are Associated with Prognosis in the Acute Phase of Ischemic Stroke

2019 ◽  
Vol 28 (3) ◽  
pp. 735-740 ◽  
Author(s):  
Aline Mansueto Mourão ◽  
Laélia Cristina Caseiro Vicente ◽  
Mery Natali Silva Abreu ◽  
Romeu Vale Sant'Anna ◽  
Erica Leandro Marciano Vieira ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Phase ◽  
Neurotrophic Factor ◽  
Plasma Levels ◽  
Brain Derived Neurotrophic Factor

scholarly journals Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

2018 ◽  
Vol 19 (12) ◽  
pp. 3782 ◽  
Author(s):  
Kristine Ravina ◽  
Denise Briggs ◽  
Sezen Kislal ◽  
Zuha Warraich ◽  
Tiffany Nguyen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Recovery ◽  
Neurotrophic Factor ◽  
Infarct Volume ◽  
Brain Derived Neurotrophic Factor ◽  
Artery Occlusion ◽  
Sensorimotor Function ◽  
Neural Repair ◽  
Adhesive Removal ◽  
Cerebral Artery Occlusion

Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived neurotrophic factor (BDNF), delivered via an extended release HyStem®-C hydrogel implant or vehicle, on sensorimotor function, infarct volume, and neuroinflammation, following permanent distal middle cerebral artery occlusion (dMCAo) in rats. Eight days following dMCAo or sham surgery, treatments were implanted directly into the infarction site. Rats received either vehicle, BDNF-only (0.167 µg/µL), hydrogel-only, hydrogel impregnated with 0.057 µg/µL of BDNF (hydrogel + BDNFLOW), or hydrogel impregnated with 0.167 µg/µL of BDNF (hydrogel + BDNFHIGH). The adhesive removal test (ART) and 28-point Neuroscore (28-PN) were used to evaluate sensorimotor function up to two months post-ischemia. The hydrogel + BDNFHIGH group showed significant improvements on the ART six to eight weeks following treatment and their behavioral performance was consistently greater on the 28-PN. Infarct volume was reduced in rats treated with hydrogel + BDNFHIGH as were levels of microglial, phagocyte, and astrocyte marker immunoexpression in the corpus striatum. These data suggest that targeted intracerebral delivery of BDNF using hydrogels may mitigate ischemic brain injury and restore functional deficits by reducing neuroinflammation.

Brain-derived neurotrophic factor G196A polymorphism predicts 90-day outcome of ischemic stroke in Chinese: A novel finding

2013 ◽  
Vol 1537 ◽  
pp. 312-318 ◽  
Author(s):  
Jing Zhao ◽  
Hui Wu ◽  
Lan Zheng ◽  
Yingfeng Weng ◽  
Yanqing Mo
Keyword(s):  
Ischemic Stroke ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Mesenchymal Stem Cells Expressing Brain-Derived Neurotrophic Factor Enhance Endogenous Neurogenesis in an Ischemic Stroke Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chang Hyun Jeong ◽  
Seong Muk Kim ◽  
Jung Yeon Lim ◽  
Chung Heon Ryu ◽  
Jin Ae Jun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ischemic Stroke ◽  
Functional Recovery ◽  
Subventricular Zone ◽  
Neurotrophic Factor ◽  
Therapeutic Potential ◽  
Brain Derived Neurotrophic Factor ◽  
Neurological Deficits ◽  
Therapeutic Benefits

Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate neurological deficits in ischemic stroke models. Among the various hypotheses that have been suggested to explain the therapeutic mechanism underlying these observations, neurogenesis is thought to be critical. To enhance the therapeutic benefits of human bone marrow-derived MSCs (hBM-MSCs), we efficiently modified hBM-MSCs by introduction of the brain-derived neurotrophic factor (BDNF) gene via adenoviral transduction mediated by cell-permeable peptides and investigated whetherBDNF-modified hBM-MSCs (MSCs-BDNF) contributed to functional recovery and endogenous neurogenesis in a rat model of middle cerebral artery occlusion (MCAO). Transplantation of MSCs induced the proliferation of 5-bromo-2′-deoxyuridine (BrdU-) positive cells in the subventricular zone. Transplantation of MSCs-BDNF enhanced the proliferation of endogenous neural stem cells more significantly, while suppressing cell death. Newborn cells differentiated into doublecortin (DCX-) positive neuroblasts and Neuronal Nuclei (NeuN-) positive mature neurons in the subventricular zone and ischemic boundary at higher rates in animals with MSCs-BDNF compared with treatment using solely phosphate buffered saline (PBS) or MSCs. Triphenyltetrazolium chloride staining and behavioral analysis revealed greater functional recovery in animals with MSCs-BDNF compared with the other groups. MSCs-BDNF exhibited effective therapeutic potential by protecting cell from apoptotic death and enhancing endogenous neurogenesis.

Sign in / Sign up

Export Citation Format

Share Document