Comparison of two powder conditioning methods to improve UO2 powder flowability for press die filling

2022 ◽  
Vol 395 ◽  
pp. 1-13
Author(s):  
E. Beaunac ◽  
M. Leturia ◽  
A.-C. Robisson ◽  
C. Ablitzer ◽  
K. Saleh
Keyword(s):  
Die Filling ◽  
Powder Flowability

Characterization of Powder Flowability for Die Filling

2012 ◽  
Vol 30 (4) ◽  
pp. 378-389 ◽  
Author(s):  
Chuan-Yu Wu ◽  
Brian Armstrong ◽  
Nikolaus Vlachos
Keyword(s):  
Die Filling ◽  
Powder Flowability

scholarly journals Impact of Powder Properties on the Rheological Behavior of Excipients

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1198
Author(s):  
Pauline H. M. Janssen ◽  
Sébastien Depaifve ◽  
Aurélien Neveu ◽  
Filip Francqui ◽  
Bastiaan H. J. Dickhoff
Keyword(s):  
Flow Field ◽  
Rheological Behavior ◽  
Quality By Design ◽  
Filling Process ◽  
Dynamic Flow ◽  
Die Filling ◽  
Flow Characterization ◽  
Wide Range ◽  
Powder Properties ◽  
The Impact

With the emergence of quality by design in the pharmaceutical industry, it becomes imperative to gain a deeper mechanistic understanding of factors impacting the flow of a formulation into tableting dies. Many flow characterization techniques are present, but so far only a few have shown to mimic the die filling process successfully. One of the challenges in mimicking the die filling process is the impact of rheological powder behavior as a result of differences in flow field in the feeding frame. In the current study, the rheological behavior was investigated for a wide range of excipients with a wide range of material properties. A new parameter for rheological behavior was introduced, which is a measure for the change in dynamic cohesive index upon changes in flow field. Particle size distribution was identified as a main contributing factor to the rheological behavior of powders. The presence of fines between larger particles turned out to reduce the rheological index, which the authors explain by improved particle separation at more dynamic flow fields. This study also revealed that obtained insights on rheological behavior can be used to optimize agitator settings in a tableting machine.

Fluidized Fill Shoe for Uniform Die Filling

2001 ◽  
Vol 189-191 ◽  
pp. 288-295 ◽  
Author(s):  
Tony F. Zahrah ◽  
Rod Rowland ◽  
George Gasbarre Jr.
Keyword(s):  
Die Filling

Uniformity of Powder Die Filling Using a Feed Shoe: A Review

2006 ◽  
Vol 24 (4) ◽  
pp. 411-426 ◽  
Author(s):  
X. Xie ◽  
V. M. Puri
Keyword(s):  
Die Filling

scholarly journals INFLUENCE OF FREE-FLOW EXCIPIENTS ON FUNCTIONAL PERFORMANCE OF NOVEONAA1 IN CONTROLLED-RELEASE TABLETS

2016 ◽  
Vol 8 (9) ◽  
pp. 6
Author(s):  
RubÉn Ramos Islas ◽  
Leopoldo Villafuerte Robles
Keyword(s):  
Drug Release ◽  
High Speed ◽  
Functional Performance ◽  
Release Profile ◽  
Free Flow ◽  
Release Mechanism ◽  
Powder Flowability ◽  
Powder Flow Rate ◽  
Controlled Release Tablets ◽  
Better Than

<p><strong>Objective: </strong>The aim of this work is the assessment of an eventual improvement in flowability of free flowing excipients on formulations containing Noveon AA1 and their influence on compactibility and release profile.</p><p><strong>Methods: </strong>Mixtures containing 20% Noveon AA1 and variable proportions of metronidazole and the free flowing excipients Prosolv EasyTab and GalenIQ 720 and 721were tested in their powder flow rate and the tablets compactibility and released profiles.</p><p><strong>Results: </strong>The powder flowability obtained with GalenIQ is about 20% better than that obtained with EasyTab. However, it is lesser than that considered as acceptable for a high-speed tableting machine. EasyTab reduces the drug release up to a half along with a continuing flattening of the release profile. This is attributed to an increasing tortuosity of the drug release path as the proportion EasyTab increases. GalenIQ restricts drug release in about a third with a lesser change in the release mechanism. This is attributed to competition for the available water inside the tablet, between the hydrating Noveon AA1 and the dissolving GalenIQ. The compactibility of the metronidazole/Noveon AA1 mixtures increases after addition of EasyTab in about 3.5 N per unit percentage of the added excipient while GalenIQ does it in about 2.6 N.</p><p><strong>Conclusion: </strong>The powder flowability of mixtures of metronidazole with Noveon AA1 was not suited for direct compression after addition of 40% of the free-flow excipient. The free-flow excipients reduce the metronidazole release rate and increase its compactibility. It was not observed a different clear functioning between both types of GalenIQ.</p>

Metal Flow and Die Filling in Coining of Micro Structures with and without Flash

2005 ◽  
Vol 6-8 ◽  
pp. 631-638 ◽  
Author(s):  
M. Thome ◽  
Gerhard Hirt ◽  
B. Rattay
Keyword(s):  
Numerical Simulations ◽  
Sheet Metal ◽  
Metal Forming ◽  
Production Systems ◽  
Metal Flow ◽  
Small Scale ◽  
Die Filling ◽  
Metal Plates ◽  
Micro Structures ◽  
Channel Structures

The continuing miniaturization of production systems and products poses a challenge for metal forming technologies to produce precise small scale products with microscopic geometric details. Thin metal plates with channel structures are considered to be typical examples for microfluidic applications [1,2]. In this study the coining process of sheet metal to produce channel and rib structures is examined in terms of geometrical die parameters and tool design. For this reason extensive experimental series and numerical simulations have been realized and evaluated.

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