scholarly journals A vicious cycle of fear of falling avoidance behavior in Parkinson’s disease: A path analysis

2021 ◽  
Vol 4 ◽  
pp. 100089
Author(s):  
Merrill R. Landers ◽  
Kameron M. Jacobson ◽  
Nicole E. Matsunami ◽  
Hannah E. McCarl ◽  
Michelle T. Regis ◽  
...  
2021 ◽  
Vol 22 (9) ◽  
pp. 4676
Author(s):  
Katja Badanjak ◽  
Sonja Fixemer ◽  
Semra Smajić ◽  
Alexander Skupin ◽  
Anne Grünewald

With the world’s population ageing, the incidence of Parkinson’s disease (PD) is on the rise. In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of PD patients. Thereby, PD progression is potentially driven by a vicious cycle between dying neurons and microglia through the instigation of oxidative stress, mitophagy and autophagy dysfunctions, a-synuclein accumulation, and pro-inflammatory cytokine release. Hence, investigating the involvement of microglia is of great importance for future research and treatment of PD. The purpose of this review is to highlight recent findings concerning the microglia-neuronal interplay in PD with a focus on human postmortem immunohistochemistry and single-cell studies, their relation to animal and iPSC-derived models, newly emerging technologies, and the resulting potential of new anti-inflammatory therapies for PD.


2018 ◽  
Vol 61 ◽  
pp. 90-97 ◽  
Author(s):  
Carla Silva-Batista ◽  
Daniel M. Corcos ◽  
Hélcio Kanegusuku ◽  
Maria Elisa Pimentel Piemonte ◽  
Lilian Teresa Bucken Gobbi ◽  
...  

2008 ◽  
Vol 14 ◽  
pp. S29
Author(s):  
M. Jahanshahi ◽  
S. Rahman ◽  
H.J. Griffin ◽  
N.P. Quinn

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Ehsan Pourghayoomi ◽  
Saeed Behzadipour ◽  
Mehdi Ramezani ◽  
Mohammad Taghi Joghataei ◽  
Gholam Ali Shahidi

2013 ◽  
Vol 3 (3) ◽  
pp. 409-413 ◽  
Author(s):  
Yvette A.M. Grimbergen ◽  
Annette Schrag ◽  
Gordon Mazibrada ◽  
George F. Borm ◽  
Bastiaan R. Bloem

2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 1389-1389
Author(s):  
M.H. Nilsson ◽  
S.B. Jonasson ◽  
B. Lindholm ◽  
P. Hagell ◽  
S. Iwarsson

2020 ◽  
Vol 10 (4) ◽  
pp. 1301-1314
Author(s):  
Joana Beisl Ramos ◽  
Gonçalo S. Duarte ◽  
Raquel Bouça-Machado ◽  
Margherita Fabbri ◽  
Tiago A. Mestre ◽  
...  

Background: Parkinson’s disease (PD) is a neurological condition characterized by the development of daily disabling symptoms. Although the architecture and design of a PD patient’s environment can hinder or facilitate full participation in daily activities, their putative role in the management of these patients has received little attention to date. Objective: We conducted a systematic review to evaluate the evidence of architectural and design features in the management of people with PD. Methods: An electronic database search of observational and experimental studies was conducted in MEDLINE and Embase from inception to May 2020, with two independent reviewers identifying the studies. Falls, fear of falling, postural instability, gait impairment/disability, and functional mobility were our outcomes of interest. Results: Thirty-six studies were included, among which nineteen were observational and seventeen were experimental studies (overall participants = 2,965). Pavement characteristics, notably unstable surfaces and level differences, were found to be a major cause of falling. Ground-based obstacles and confined/narrowed spaces were found to disturb gait, increase postural instability, and decrease functional mobility. Housing type did not appear to increase risk of falling, nor to significantly explain concerns about falling. Conclusion: Findings suggest a need to adjust architectural features of the surrounding space to ensure appropriate care and provide a safe environment to PD patients. More evidence about the impact of such modifications on PD outcomes is needed.


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