P 36 Association of placental oxidative stress and pregnancy outcome in patients with hypertensive disorders of pregnancy – A pilot study in an Indian population

2017 ◽  
Vol 9 ◽  
pp. 53-54
Author(s):  
Vickneshwaran Vinayagam ◽  
Zachariah Bobby ◽  
Syed Habeebullah ◽  
Shruti Bharadwaj ◽  
Angelin Jeba Malar Abraham
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
Pregnancy Outcome ◽  
Indian Population ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Placental Oxidative Stress

scholarly journals Placental Oxidative Stress in the pathogenesis of Hypertensive Disorders of Pregnancy

2021 ◽  
Vol 1 (2) ◽  
pp. 39-49
Author(s):  
Martin Awe Akilla
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Stress Index ◽  
Control Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Oxidative Stress Index ◽  
Hypertensive Disorders ◽  
Total Antioxidant ◽  
Placental Oxidative Stress

Background: Hypertensive disorders of pregnancy are a major complication of pregnancies and can lead to fetal growth retardation, premature delivery and maternal morbidity and mortality. The study aimed at assessing the potential role of the placenta in the pathogenesis of hypertensive disorders of pregnancy. Methods: This study was a case-control study conducted at the Upper East Regional Hospital, Ghana from September, 2016 to March 2017. Twenty (20) pregnant women with hypertensive disorders of pregnancy (i.e., Pregnancy induced hypertension, preeclampsia and eclampsia) as cases and 30 normotensive pregnancies as controls, were included in the study. The placenta was excised after delivery, homogenized and assayed for malondialdehyde, catalase, total peroxide, oxidative stress index, total antioxidant capacity and placental lipid profile. Results: The ages of the two groups were similar, with malondialdehyde (p = 0.001) and Oxidative Stress Index (p < 0.001) being significantly higher in the hypertensive group compared to the control group whereas Total Antioxidant Capacity (p < 0.001) and Catalase (p = 0.011) were significantly higher in the control group compared to the hypertensive group. The proportion of normal, term and livebirth deliveries were significantly higher among controls compared to the hypertensive disorders of pregnancy group. Among the estimated oxidative stress markers, total antioxidant capacity turned out to be the best predictor of the hypertensive disorders of pregnancy. Conclusion: Our findings suggest oxidative stress in women with hypertensive disorders of pregnancy and that placental oxidative stress could be the driving factor for the pathogenesis and severity of these hypertensive disorders of pregnancy.

95. Defective angiogenic markers and poor pregnancy outcomes in patients with hypertensive disorders of pregnancy: A pilot study in an Indian Population

2018 ◽  
Vol 13 ◽  
pp. S20-S21
Author(s):  
Vickneshwaran Vinayagam ◽  
Zachariah Bobby ◽  
Habeebullah Syed ◽  
Latha Chaturvedula ◽  
Shruti K Bharadwaj ◽  
...  
Keyword(s):  
Pilot Study ◽  
Pregnancy Outcomes ◽  
Indian Population ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Angiogenic Markers

OP 50 Pilot study of alterations in urinary antioxidant-associated micronutrients in women with hypertensive disorders of pregnancy

2017 ◽  
Vol 9 ◽  
pp. 31
Author(s):  
Hiten Mistry ◽  
David Gardner ◽  
Fiona Broughton Pipkin ◽  
Helena Strevens ◽  
Lesia Kurlak
Keyword(s):  
Pilot Study ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

ETHENE AND OTHER BIOMARKERS OF OXIDATIVE STRESS IN HYPERTENSIVE DISORDERS OF PREGNANCY

2002 ◽  
Vol 21 (1) ◽  
pp. 39-49 ◽  
Author(s):  
P. L. M. Zusterzeel ◽  
R. P. M. Steegers-Theunissen ◽  
F. J. M. Harren ◽  
E. Stekkinger ◽  
H. Kateman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Biomarkers Of Oxidative Stress
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