Estimation of the sensitivity and specificity of four serum ELISA and one fecal PCR for diagnosis of paratuberculosis in adult dairy cattle in New Zealand using Bayesian latent class analysis

2020 ◽  
Vol 185 ◽  
pp. 105199
Author(s):  
Andrew Bates ◽  
Richard Laven ◽  
Rory O’Brien ◽  
Simon Liggett ◽  
Frank Griffin
Keyword(s):  
New Zealand ◽  
Dairy Cattle ◽  
Latent Class Analysis ◽  
Sensitivity And Specificity ◽  
Latent Class ◽  
Class Analysis ◽  
Serum Elisa ◽  
Bayesian Latent Class Analysis

Evaluation of post-mortem diagnostic tests' sensitivity and specificity for bovine tuberculosis using Bayesian latent class analysis

2019 ◽  
Vol 125 ◽  
pp. 14-23
Author(s):  
Paulo Martins Soares Filho ◽  
Alberto Knust Ramalho ◽  
André de Moura Silva ◽  
Mikael Arrais Hodon ◽  
Marina de Azevedo Issa ◽  
...  
Keyword(s):  
Latent Class Analysis ◽  
Sensitivity And Specificity ◽  
Bovine Tuberculosis ◽  
Diagnostic Tests ◽  
Latent Class ◽  
Post Mortem ◽  
Class Analysis ◽  
Bayesian Latent Class Analysis

scholarly journals Diagnostic Test Accuracy in Childhood Pulmonary Tuberculosis: A Bayesian Latent Class Analysis

2016 ◽  
Vol 184 (9) ◽  
pp. 690-700 ◽  
Author(s):  
Samuel G. Schumacher ◽  
Maarten van Smeden ◽  
Nandini Dendukuri ◽  
Lawrence Joseph ◽  
Mark P. Nicol ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Latent Class Analysis ◽  
Chest Radiography ◽  
Latent Class ◽  
Credible Interval ◽  
Smear Microscopy ◽  
Test Accuracy ◽  
Class Analysis ◽  
Antituberculosis Treatment ◽  
Bayesian Latent Class Analysis

AbstractEvaluation of tests for the diagnosis of childhood pulmonary tuberculosis (CPTB) is complicated by the absence of an accurate reference test. We present a Bayesian latent class analysis in which we evaluated the accuracy of 5 diagnostic tests for CPTB. We used data from a study of 749 hospitalized South African children suspected to have CPTB from 2009 to 2014. The following tests were used: mycobacterial culture, smear microscopy, Xpert MTB/RIF (Cepheid Inc.), tuberculin skin test (TST), and chest radiography. We estimated the prevalence of CPTB to be 27% (95% credible interval (CrI): 21, 35). The sensitivities of culture, Xpert, and smear microscopy were estimated to be 60% (95% CrI: 46, 76), 49% (95% CrI: 38, 62), and 22% (95% CrI: 16, 30), respectively; specificities of these tests were estimated in accordance with prior information and were close to 100%. Chest radiography was estimated to have a sensitivity of 64% (95% CrI: 55, 73) and a specificity of 78% (95% CrI: 73, 83). Sensitivity of the TST was estimated to be 75% (95% CrI: 61, 84), and it decreased substantially among children who were malnourished and infected with human immunodeficiency virus (56%). The specificity of the TST was 69% (95% CrI: 63%, 76%). Furthermore, it was estimated that 46% (95% CrI: 42, 49) of CPTB-negative cases and 93% (95% CrI: 82; 98) of CPTB-positive cases received antituberculosis treatment, which indicates substantial overtreatment and limited undertreatment.

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