Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression

AbstractBackground:Adults with type 2 diabetes (T2D) have significantly lower gray matter volume (GMV) compared to healthy peers. Whether GMV differences exist in youth with T2D remains unclear. Thus, we compared global and regional GMV between obese youth with T2D with age, race and sex similar healthy controls.Methods:In a cross-sectional study, 20 obese youth with T2D underwent T1-weighted brain magnetic resonance imaging (MRI). Comparisons were made to 20 age, race and sex similar controls. Differences in global and regional GMV between groups were identified using voxel-based morphometry (VBM).Results:Youth with T2D had a significantly lower global GMV-to-intracranial volume ratio (0.51±0.02 in T2D vs. 0.53±0.02 in controls, p=0.02, Cohen’sd=0.85). There were 14 regions where GMV was significantly lower in the T2D group, and nine of these were found in either the temporal or occipital lobes. There were six regions with increased GMV in T2D. All regional differences were significant at p<0.05 after adjusting for multiple comparisons.Conclusions:Results from this pilot study show obese youth with T2D have significantly lower global GMV and regional GMV differences, when compared to their age, race and sex similar peers. Future work is needed to determine whether these brain findings are a direct result of adolescent-onset T2D.

Download Full-text

Cognitive behavioural therapy in elderly type 2 diabetes patients with minor depression or mild major depression: study protocol of a randomized controlled trial (MIND-DIA)

BMC Geriatrics ◽

10.1186/1471-2318-10-21 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 12

Author(s):

Frank Petrak ◽

Martin Hautzinger ◽

Kristin Plack ◽

Kai Kronfeld ◽

Christian Ruckes ◽

...

Keyword(s):

Type 2 Diabetes ◽

Randomized Controlled Trial ◽

Major Depression ◽

Cognitive Behavioural Therapy ◽

Controlled Trial ◽

Behavioural Therapy ◽

Minor Depression ◽

Randomized Controlled ◽

Cognitive Behavioural

Download Full-text

Cognitive behavioural therapy in elderly type 2 diabetes patients with minor depression or mild major depression

http://isrctn.org/> ◽

10.1186/isrctn58007098 ◽

2013 ◽

Author(s):

Frank Petrak

Keyword(s):

Type 2 Diabetes ◽

Major Depression ◽

Cognitive Behavioural Therapy ◽

Behavioural Therapy ◽

Minor Depression ◽

Cognitive Behavioural ◽

Diabetes Patients

Download Full-text

Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus

Metabolism ◽

10.1016/j.metabol.2014.07.008 ◽

2014 ◽

Vol 63 (11) ◽

pp. 1390-1397 ◽

Cited By ~ 12

Author(s):

Disha Mehta ◽

Daniela A. Pimentel ◽

Maria-Zunilda Núñez ◽

Amir Abduljalil ◽

Vera Novak

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gray Matter ◽

Gray Matter Atrophy

Download Full-text

Post-Craniopharyngioma and Cranial Nerve-VI Palsy Update on a MS Patient with Major Depression and Concurrent Neuroimmune Conditions

Brain Sciences ◽

10.3390/brainsci9100281 ◽

2019 ◽

Vol 9 (10) ◽

pp. 281 ◽

Cited By ~ 2

Author(s):

Navzer D. Sachinvala ◽

Angeline Stergiou ◽

Duane E. Haines ◽

Armen Kocharian ◽

Andrew Lawton

Keyword(s):

Multiple Sclerosis ◽

Type 2 Diabetes ◽

Major Depression ◽

Cranial Nerve ◽

Chronic Conditions ◽

Magnetic Resonance Image ◽

Fiber Layer ◽

Major Depressive ◽

Nerve Fiber Layer Thickness

We report the case of a male multiple sclerosis (MS) patient with type 2 diabetes (T2D), asthma, major depression (MD or major depressive disorder, MDD), and other chronic conditions, after his recent difficulties with craniopharyngioma and cranial nerve-VI (CN6) palsy. In addition, we show magnetic resonance image and spectroscopy (MRI, MRS), Humphrey’s Visual Field (HVF), and retinal nerve fiber layer thickness (RNFLT) findings to explain the changes in the patient’s health, and discuss the methods that helped/help him sustain productivity and euthymia despite long-standing problems and new CNS changes.

Download Full-text

Detection and prevalence of depression among adult type 2 diabetes mellitus patients attending non-communicable diseases clinics in Lilongwe, Malawi

International Journal of Mental Health Systems ◽

10.1186/s13033-020-00413-3 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Michael Udedi ◽

Brian W. Pence ◽

Robert C. Stewart ◽

Adamson S. Muula

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Major Depression ◽

Sociodemographic Factors ◽

Adult Type ◽

Non Communicable Diseases ◽

Prevalence Of Depression ◽

Dsm Iv

Abstract Background Depression is associated with chronic physical illnesses and negatively affects health outcomes. However, it often goes undiagnosed and untreated. We investigated the prevalence of depression among adult type 2 diabetes mellitus (T2DM) patients attending non-communicable diseases (NCD) clinics in Lilongwe, Malawi, and estimated the level of routine detection by NCD clinicians. This study set out to determine the prevalence of major depression and its detection among adult type 2 diabetes mellitus (T2DM) patients attending NCD clinics in Lilongwe, Malawi. Methods In a cross-sectional study design, 323 T2DM patients aged ≥ 18 years were screened for depression with the Patient Health Questionnare-9 (PHQ-9) followed by diagnostic assessment with the Structured Clinical Interview for DSM-IV (SCID). We analysed the association between presence of major depression and sociodemographic factors using logistic regression. Results Three quarters of the participants (76%) were females. The participants’ ages ranged from 21–79 years. Of the 323 participants, 58 (18%) met criteria for DSM-IV major depression. None of the cases of major depression had been identified by the NCD clinicians. Major depression was found not to be significantly associated with any of the sociodemographic factors. Conclusions We found that depression is common among NCD clinic attendees with T2DM in Malawi, and poorly detected by NCD clinicians. Given the high prevalence and challenges in clinical identification, integration of depression screening with a standardized validated tool should be a high priority so as to link patients to appropriate services.

Download Full-text