Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study

2017 ◽  
Vol 85 ◽  
pp. 14-19 ◽  
Author(s):  
Mary R. Lee ◽  
Melanie L. Schwandt ◽  
Vignesh Sankar ◽  
Petra Suchankova ◽  
Hui Sun ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xu Chen ◽  
Yunmeng Pan ◽  
Peiru Xu ◽  
Yi Huang ◽  
Nan Li ◽  
...  

Abstract Objective To explore the influence of childhood trauma and family alcohol use on male alcohol use disorder. Methods We conducted a case-control study using Childhood Trauma Questionnaire (CTQ) and a structured interview involving 129 men with alcohol use disorder and 129 healthy male volunteers. The two groups were compared in terms of childhood trauma, parental drinking behavior, and attitudes toward childhood drinking. Results Patients showed higher scores of CTQ than controls on childhood trauma experiences, including on the subscales of physical abuse, emotional abuse, sexual abuse, and emotional neglect. Higher proportions of patients than controls had fathers who drank seven or more times a week, and had mothers who were opposed to childhood drinking. Conversely, a smaller proportion of patients than controls had fathers who opposed childhood drinking. Patients were more likely than controls to have been induced to drink as children. Logistic regression analysis identified three risk factors for alcohol use disorder: induced drinking during childhood [odds ratio (OR) 6.09, 95% confidence interval (CI) 2.56–14.51], the father’s weekly alcohol consumption during the respondent’s childhood (OR 4.40, 95%CI 2.94–6.58) and history of smoking (OR 3.39, 95%CI 1.48–7.77). Conversely, more years of education were a protective factor against alcohol use disorder (OR 0.88, 95% CI 0.78–0.99). Conclusions Men whose fathers drank frequently during their childhood and were encouraged to drink may be at increased risk of alcohol use disorder in adulthood. In fact these factors of family alcohol use appear to increase risk of alcohol use disorder among adult men more than exposure to childhood trauma does.


2008 ◽  
Vol 20 (5) ◽  
pp. 645-652 ◽  
Author(s):  
Xavier León ◽  
María del Prado Venegas ◽  
César Orús ◽  
Montserrat López ◽  
Jacinto García ◽  
...  

Stroke ◽  
2019 ◽  
Vol 50 (Suppl_1) ◽  
Author(s):  
Sho Murase ◽  
Shuhei Okazaki ◽  
Kenichi Todo ◽  
Yusuke Misumi ◽  
Daisuke Yoshioka ◽  
...  

Addiction ◽  
2008 ◽  
Vol 103 (7) ◽  
pp. 1198-1205 ◽  
Author(s):  
Lisia von Diemen ◽  
Diego Garcia Bassani ◽  
Sandra Costa Fuchs ◽  
Claudia Maciel Szobot ◽  
Flavio Pechansky

BMJ Open ◽  
2013 ◽  
Vol 3 (11) ◽  
pp. e003304 ◽  
Author(s):  
Gregor John ◽  
Sephora Pasche ◽  
Nicole Rothen ◽  
Alexia Charmoy ◽  
Cécile Delhumeau-Cartier ◽  
...  

2018 ◽  
Vol 18 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Aneta Zwierzchowska ◽  
Anna Iwan ◽  
Anna Hyc ◽  
Barbara Suchońska ◽  
Jacek Malejczyk ◽  
...  

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