Corrigendum to “Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala” [Psychoneuroendocrinology 69 (2016) 189–196]

AbstractThe persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2 h) in rats induces a late anxiety-related behavior (observed ten days after stress), whereas, in the present work, we found that the same stress impaired fear extinction in animals conditioned ten days after stress. Fourteen days of environmental enrichment (EE) prevented the deleterious effect of stress on fear memory extinction. Additionally, we observed that EE prevented the stress-induced increase in AMPA receptor GluA1 subunit phosphorylation in the hippocampus, but not in the basolateral amygdala complex and the frontal cortex, indicating a potential mechanism by which it exerts its protective effect against the stress-induced behavioral outcome.

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Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged, female mice

Brain Research ◽

10.1016/j.brainres.2007.05.033 ◽

2007 ◽

Vol 1160 ◽

pp. 91-101 ◽

Cited By ~ 30

Author(s):

Jodi E. Gresack ◽

Kristin M. Kerr ◽

Karyn M. Frick

Keyword(s):

Environmental Enrichment ◽

Short Term ◽

Female Mice

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Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1524739113 ◽

2016 ◽

Vol 113 (18) ◽

pp. 5089-5094 ◽

Cited By ~ 18

Author(s):

Yao-Ying Ma ◽

Xiusong Wang ◽

Yanhua Huang ◽

Helene Marie ◽

Eric J. Nestler ◽

...

Keyword(s):

Environmental Enrichment ◽

Behavioral Treatment ◽

Basolateral Amygdala ◽

Drug Exposure ◽

Therapeutic Effects ◽

Self Administration ◽

Cocaine Withdrawal ◽

Silent Synapses ◽

Cocaine Craving

Environmental enrichment (EE) has long been postulated as a behavioral treatment for drug addiction based on its preventive effects in animal models: rodents experiencing prior EE exhibit increased resistance to establishing drug taking and seeking. However, the therapeutic effects of EE, namely, the effects of EE when applied after drug exposure, are often marginal and transient. Using incubation of cue-induced cocaine craving, a rat relapse model depicting progressive intensification of cocaine seeking after withdrawal from cocaine self-administration, our present study reveals that after cocaine withdrawal, in vivo circuit-specific long-term depression (LTD) unmasks the therapeutic power of EE to achieve long-lasting anti-relapse effects. Specifically, our previous results show that cocaine self-administration generates AMPA receptor (AMPAR)-silent excitatory synapses within the basolateral amygdala (BLA) to nucleus accumbens (NAc) projection, and maturation of these silent synapses via recruiting calcium-permeable (CP) AMPARs contributes to incubation of cocaine craving. Here, we show that after cocaine withdrawal and maturation of silent synapses, the BLA-to-NAc projection became highly resistant to EE. However, optogenetic LTD applied to this projection in vivo transiently re-silenced these silent synapses by removing CP-AMPARs. During this transient window, application of EE resulted in the insertion of nonCP-AMPARs, thereby remodeling the “incubated” BLA-to-NAc projection. Consequently, incubation of cocaine craving was decreased persistently. These results reveal a mechanistic basis through which the persistent anti-relapse effects of EE can be unleashed after drug withdrawal.

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Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

PLoS ONE ◽

10.1371/journal.pone.0016832 ◽

2011 ◽

Vol 6 (2) ◽

pp. e16832 ◽

Cited By ~ 62

Author(s):

Jorge Valero ◽

Judit España ◽

Arnaldo Parra-Damas ◽

Elsa Martín ◽

José Rodríguez-Álvarez ◽

...

Keyword(s):

Transgenic Mice ◽

Adult Neurogenesis ◽

Environmental Enrichment ◽

Memory Deficits ◽

Short Term

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Endocannabinoid- and mGluR5-Dependent Short-Term Synaptic Depression in an Isolated Neuron/Bouton Preparation From the Hippocampal CA1 Region

Journal of Neurophysiology ◽

10.1152/jn.90226.2008 ◽

2008 ◽

Vol 100 (2) ◽

pp. 1041-1052 ◽

Cited By ~ 21

Author(s):

Anton Sheinin ◽

Giuseppe Talani ◽

Margaret I. Davis ◽

David M. Lovinger

Keyword(s):

Hippocampal Neurons ◽

Basolateral Amygdala ◽

Pyramidal Neurons ◽

Metabotropic Glutamate Receptor ◽

Hippocampal Slices ◽

Neuronal Membrane ◽

Short Term ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Isolated Neuron

Endocannabinoids released from the postsynaptic neuronal membrane can activate presynaptic CB1 receptors and inhibit neurotransmitter release. In hippocampal slices, depolarization of the CA1 pyramidal neurons elicits an endocannabinoid-mediated inhibition of γ-aminobutyric acid release known as depolarization-induced suppression of inhibition (DSI). Using the highly reduced neuron/synaptic bouton preparation from the CA1 region of hippocampus, we have begun to examine endocannabinoid-dependent short-term depression (STD) of inhibitory synaptic transmission under well-controlled physiological and pharmacological conditions in an environment free of other cells. Application of the CB1 synthetic agonist WIN55212 -2 and endogenous cannabinoids 2-AG and anandamide produced a decrease in spontaneous inhibitory postsynaptic current (sIPSC) frequency and amplitude, indicating the presence of CB1 receptors at synapses in this preparation. Endocannabinoid-dependent STD is different from DSI found in hippocampal slices and the neuron/bouton preparation from basolateral amygdala (BLA) since depolarization alone was not sufficient to induce suppression of sIPSCs. However, concurrent application of the metabotropic glutamate receptor (mGluR) agonist ( RS)-3,5-dihydroxyphenylglycine (DHPG) and postsynaptic depolarization resulted in a transient (30–50 s) decrease in sIPSC frequency and amplitude. Application of DHPG alone had no effect on sIPSCs. The depolarization/DHPG-induced STD was blocked by the CB1 antagonist SR141716A and the mGluR5 antagonist MPEP and was sensitive to intracellular calcium concentration. Comparing the present findings with earlier work in hippocampal slices and BLA, it appears that endocannabinoid release is less robust in isolated hippocampal neurons.

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Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats

Neuroscience ◽

10.1016/j.neuroscience.2016.05.020 ◽

2016 ◽

Vol 329 ◽

pp. 294-305 ◽

Cited By ~ 21

Author(s):

Liana R. Stein ◽

Kazuko A. O’Dell ◽

Michiyo Funatsu ◽

Charles F. Zorumski ◽

Yukitoshi Izumi

Keyword(s):

Synaptic Plasticity ◽

Environmental Enrichment ◽

Hippocampal Slices ◽

Aged Rats ◽

Short Term

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Short-Term Impact of Point-Source Enrichment on the Behavior of Gestating Sows Housed in Groups

Frontiers in Animal Science ◽

10.3389/fanim.2021.649114 ◽

2021 ◽

Vol 2 ◽

Author(s):

Perle E. Zhitnitskiy ◽

Claire M. H. A. Terreaux ◽

Hannah N. Phillips ◽

Beth A. Ventura

Keyword(s):

Point Source ◽

Environmental Enrichment ◽

Video Recording ◽

Crossover Design ◽

Farm Animals ◽

Time Budgets ◽

Short Term ◽

Design Time ◽

The Impact ◽

To Receive

Environmental enrichment is an important strategy to improve the welfare of farm animals. However, relatively little is known about enrichment for gestating sows, especially those raised on farms with slatted floors and for which provision of straw may be difficult. The objective of this study was therefore to investigate the short-term (4 d) impact of a point-source enrichment object on the behavior of gestating sows housed in group pens. Four pens of gestating sows on a university research farm were randomly allocated to receive either enrichment or no enrichment (control) in a 2 by 2 crossover design. Time budgets were established by video recording focal sows' behaviors (n = 10 focals per pen) every 15 min between 0800 and 1500 every day. Enrichment use was further characterized by continuous behavior sampling for a 1 h interval between 0830 and 0930 each day. The impact of parity, lameness and presence of stereotypical behavior such as sham chewing on enrichment use was evaluated. Over the course of the study, focal sows spent approximately 73% of observations inactive [either lying down (70%), standing (2%), or sitting (1%)]. Within the remaining observations, sows were most commonly observed sham-chewing (16%), followed by 3% exploring, 2% feeding, 2% walking and 1% interacting with the enrichment when it was available. Low-parity sows, moderately-lame sows, and sows observed sham chewing at baseline displayed more consistent enrichment use over the course of the study (p = 0.02, p < 0.01, p = 0.04, respectively). While no adverse behavioral effects (increased agonism or sham chewing) due to provision or removal of the enrichment object were observed and while 85% of sows were observed to interact with enrichment at least once, interest declined sharply after the first day. We conclude that further research is needed to identify effective and sustainable enrichment strategies for gestating sows.

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