Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation

2007 ◽  
Vol 83 (3) ◽  
pp. 304-310 ◽  
Author(s):  
Ala Yaromina ◽  
Marie Krause ◽  
Howard Thames ◽  
Andrea Rosner ◽  
Mechthild Krause ◽  
...  
Keyword(s):  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour ◽  
Pre Treatment ◽  
Treatment Number ◽  
Clonogenic Cells

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

2013 ◽  
Vol 108 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Mechthild Krause ◽  
Berit Kummer ◽  
Andre Deparade ◽  
Wolfgang Eicheler ◽  
Dorothee Pfitzmann ◽  
...  
Keyword(s):  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation

2010 ◽  
Vol 96 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Ala Yaromina ◽  
Howard Thames ◽  
Xuanjing Zhou ◽  
Sandra Hering ◽  
Wolfgang Eicheler ◽  
...  
Keyword(s):  
Tumour Microenvironment ◽  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo

2012 ◽  
Vol 102 (3) ◽  
pp. 444-449 ◽  
Author(s):  
Kristin Gurtner ◽  
Franziska Hessel ◽  
Wolfgang Eicheler ◽  
Annegret Dörfler ◽  
Daniel Zips ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Nuklearmedizin trifft Strahlentherapie

2010 ◽  
Vol 49 (S 01) ◽  
pp. S11-S15
Author(s):  
C. Schütze ◽  
M. Krause ◽  
A. Yaromina ◽  
D. Zips ◽  
M. Baumann
Keyword(s):  
Nuclear Medicine ◽  
Radiation Oncology ◽  
External Beam Radiotherapy ◽  
Biological Knowledge ◽  
Important Research ◽  
Tumour Control ◽  
Research Areas ◽  
Normal Tissue Damage ◽  
Local Tumour Control ◽  
Local Tumour

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

PO-1926 Enhanced local tumour control by combining proton radiation and immunotherapy

2021 ◽  
Vol 161 ◽  
pp. S1642
Author(s):  
M. Horsman ◽  
S. Nielsen ◽  
M. Sitarz ◽  
M. Høyer ◽  
B. Sørensen
Keyword(s):  
Proton Radiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

2010 ◽  
Vol 9 (1) ◽  
pp. 53-61
Author(s):  
Jeremy P. Appleton ◽  
Peter Bridge
Keyword(s):  
Conservative Treatment ◽  
Proton Therapy ◽  
Normal Tissue ◽  
Treatment Options ◽  
Choroidal Melanoma ◽  
Review Of The Literature ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour ◽  
Plaque Brachytherapy

AbstractThe aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

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