1357 ORAL Improvement of local tumour control after simultaneous fractionated irradiation and EGFR inhibition by C225 in FaDu hSCC in vivo is caused by the combined effect of decreased repopulation and increased reoxygenation

2005 ◽  
Vol 3 (2) ◽  
pp. 392
Keyword(s):  
Combined Effect ◽  
Fractionated Irradiation ◽  
Tumour Control ◽  
Egfr Inhibition ◽  
Local Tumour Control ◽  
Local Tumour

Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo

2012 ◽  
Vol 102 (3) ◽  
pp. 444-449 ◽  
Author(s):  
Kristin Gurtner ◽  
Franziska Hessel ◽  
Wolfgang Eicheler ◽  
Annegret Dörfler ◽  
Daniel Zips ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Simultaneous PLK1 inhibition improves local tumour control after fractionated irradiation

2013 ◽  
Vol 108 (3) ◽  
pp. 422-428 ◽  
Author(s):  
Mechthild Krause ◽  
Berit Kummer ◽  
Andre Deparade ◽  
Wolfgang Eicheler ◽  
Dorothee Pfitzmann ◽  
...  
Keyword(s):  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation

2010 ◽  
Vol 96 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Ala Yaromina ◽  
Howard Thames ◽  
Xuanjing Zhou ◽  
Sandra Hering ◽  
Wolfgang Eicheler ◽  
...  
Keyword(s):  
Tumour Microenvironment ◽  
Fractionated Irradiation ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Local Tumour

Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

2011 ◽  
Vol 99 (3) ◽  
pp. 323-330 ◽  
Author(s):  
Kristin Gurtner ◽  
Yvonne Deuse ◽  
Rebecca Bütof ◽  
Katja Schaal ◽  
Wolfgang Eicheler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Egfr Gene ◽  
Tumour Control ◽  
Egfr Inhibition ◽  
Local Tumour Control ◽  
Local Tumour ◽  
Tk Inhibitors

scholarly journals Cancer Stem Cell Biomarkers Predictive of Radiotherapy Response in Rectal Cancer: A Systematic Review

Genes ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1502
Author(s):  
Marzia Mare ◽  
Lorenzo Colarossi ◽  
Veronica Veschi ◽  
Alice Turdo ◽  
Dario Giuffrida ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
In Vivo Studies ◽  
Tumour Control ◽  
Scientific Databases ◽  
Local Tumour Control ◽  
Close Proximity ◽  
Current Scenario ◽  
Local Tumour

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients.

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