Combined treatment of the immunoconjugate bivatuzumab mertansine and fractionated irradiation improves local tumour control in vivo

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients.

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2006 Local tumour control after simultaneous fractionated irradiation and EGFR-blockade by monoclonal antibodies (Cetuximab) versus tyrosine kinase inhibitors (Erlotinib) in different head and neck squamous cell carcinoma (HNSCC) models

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(09)70522-1 ◽

2009 ◽

Vol 7 (2) ◽

pp. 153 ◽

Cited By ~ 1

Author(s):

M. Krause ◽

K. Gurtner ◽

Y. Deuse ◽

W. Eicheler ◽

M. Baumann

Keyword(s):

Squamous Cell Carcinoma ◽

Monoclonal Antibodies ◽

Tyrosine Kinase ◽

Cell Carcinoma ◽

Head And Neck ◽

Kinase Inhibitors ◽

Fractionated Irradiation ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour

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Nuklearmedizin trifft Strahlentherapie

Nuklearmedizin ◽

10.1055/s-0038-1626533 ◽

2010 ◽

Vol 49 (S 01) ◽

pp. S11-S15

Author(s):

C. Schütze ◽

M. Krause ◽

A. Yaromina ◽

D. Zips ◽

M. Baumann

Keyword(s):

Nuclear Medicine ◽

Radiation Oncology ◽

External Beam Radiotherapy ◽

Biological Knowledge ◽

Important Research ◽

Tumour Control ◽

Research Areas ◽

Normal Tissue Damage ◽

Local Tumour Control ◽

Local Tumour

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

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